Donepezil: A Review of Pharmacological Characteristics and Role in the Management of Alzheimer Disease

2017 ◽  
Vol 10 ◽  
Keyword(s):  
Alzheimer Disease

Structural and Chemical Studies of Pathological Fibers in Human Neurofibrillary Degeneration

1985 ◽  
Vol 43 ◽  
pp. 726-729
Author(s):  
K.S. Kosik ◽  
L.K. Duffy ◽  
S. Bakalis ◽  
C. Abraham ◽  
D.J. Selkoe
Keyword(s):  
Monoclonal Antibodies ◽  
Alzheimer Disease ◽  
Human Brain ◽  
Neurofibrillary Tangles ◽  
Morphological Analysis ◽  
High Specificity ◽  
Cytoskeletal Proteins ◽  
Neuritic Plaque ◽  
Protein Chemistry ◽  
Chemical Studies

The major structural lesions of the human brain during aging and in Alzheimer disease (AD) are the neurofibrillary tangles (NFT) and the senile (neuritic) plaque. Although these fibrous alterations have been recognized by light microscopists for almost a century, detailed biochemical and morphological analysis of the lesions has been undertaken only recently. Because the intraneuronal deposits in the NFT and the plaque neurites and the extraneuronal amyloid cores of the plaques have a filamentous ultrastructure, the neuronal cytoskeleton has played a prominent role in most pathogenetic hypotheses.The approach of our laboratory toward elucidating the origin of plaques and tangles in AD has been two-fold: the use of analytical protein chemistry to purify and then characterize the pathological fibers comprising the tangles and plaques, and the use of certain monoclonal antibodies to neuronal cytoskeletal proteins that, despite high specificity, cross-react with NFT and thus implicate epitopes of these proteins as constituents of the tangles.

Sensory Motor Tasks in Identification of Alzheimer Disease Using CART

2009 ◽  
Author(s):  
Anya Mazur-Mosiewicz ◽  
Matthew J. Holcomb ◽  
Raymond S. Dean
Keyword(s):  
Alzheimer Disease ◽  
Motor Tasks ◽  
Sensory Motor

Potassium-Sparing Diuretics Associated With Decreased Risk of Alzheimer Disease

2006 ◽  
Author(s):  
A. Khachaturian ◽  
P. Zandi ◽  
C. G. Lyketsos ◽  
K. M. Hayden ◽  
I. Skoog ◽  
...  
Keyword(s):  
Alzheimer Disease
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