scholarly journals Electronic Cigarette: Role in the Primary Prevention of Oral Cavity Cancer

2016 ◽  
Vol 9 ◽  
pp. CMENT.S40364 ◽  
Author(s):  
Teresa Franco ◽  
Serena Trapasso ◽  
Lidia Puzzo ◽  
Eugenia Allegra
Keyword(s):  
Primary Prevention ◽  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Electronic Cigarettes ◽  
Micronucleus Assay ◽  
Electronic Cigarette ◽  
Cytologic Examination ◽  
Oral Cavity Carcinoma ◽  
Gender And Age ◽  
Tobacco Addiction

Background Cigarette smoke has been identified as the main cause of oral cavity carcinoma. Recently, the electronic cigarette, a battery-operated device, was developed to help smokers stop their tobacco addiction. This study aimed to evaluate the safety of electronic cigarettes and to establish the possible role of such device in the primary prevention of oral cavity cancer. Subjects and Methods This study included 65 subjects who were divided into three groups (smokers, e-cigarette smokers, and nonsmokers). All subjects were submitted to cytologic examination by scraping of oral mucosa. The slides were microscopically evaluated through a micronucleus assay test. Results The prevalence of micronuclei was significantly decreased in the e-cigarette smoker group. There were no statistically significant differences in micronuclei distribution according to the type of cigarette, gender, and age. Conclusions The use of electronic cigarettes seems to be safe for oral cells and should be suggested as an aid to smoking cessation.

scholarly journals Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India

2016 ◽  
Vol 05 (02) ◽  
pp. 052-055 ◽  
Author(s):  
Avinash Pandey ◽  
A. Desai ◽  
V. Ostwal ◽  
V. Patil ◽  
A. Kulkarni ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Locally Advanced ◽  
Disease Free Survival ◽  
Metronomic Chemotherapy ◽  
Tobacco Consumption ◽  
Rural India ◽  
Rank Test ◽  
Factors Affecting ◽  
Oral Cavity Carcinoma

Abstract Background: Oral cavity cancer is the most common cancer among rural India. There is a paucity of data for outcomes of operable oral cavity cancer from rural India. Use of maintenance metronomic may delay or avoid relapse. Aim: To evaluate outcomes of operable oral cavity carcinoma and evaluate impact of maintenance metronomic chemotherapy. Objectives: To evaluate disease-free survival (DFS), overall survival (OS), and factors affecting the outcome in operable oral cavity cancer. Materials and Methods: Data of patients diagnosed with oral cavity cancer registered between May 2008 and May 2014 were retrieved. Only those patients with operable oral cavity cancer and upfront definitive surgery were included in the study. Demographic profile, stage, tobacco consumption, adjuvant therapy, and pattern of failure were collected. Kaplan-Meir survival analysis was used to determine DFS and OS. Log-rank test was used to evaluate factors affecting outcome. Results: Median follow-up is 24 months. Out of 335 patients, 225 (67%) had advanced operable cancer with 42/225 (18%) and 183/225 (82%) as Stages III and IVA, respectively. Buccal mucosa was the most common subsite (178/335, 53%) followed by tongue (63/335, 19%). Ninety-two percent patients were addicted to smokeless tobacco, whereas 27% were smokers. Median DFS is 13 months with 2 years relative DFS 32%. Median OS is 30 months, with 2 years OS of 54%. Metronomic adjuvant oral chemotherapy was given in 130/225 (58%); Stage III and IVA patients with median of 14 months (3-18 months). Use of metronomic chemotherapy improved DFS (8 vs. 14 months, P = 0.22) and OS (14 vs. 26 months, P = 0.04). Conclusion: Oral cavity cancer is a major health care problem in rural India. Presentation at advanced stage leads to suboptimal outcomes. Benefit of metronomic maintenance chemotherapy in locally advanced oral cavity needs to be further evaluated prospectively.

Vaping the Venom: Oral Cavity Cancer in a Young Adult With Extensive Electronic Cigarette Use

PEDIATRICS ◽  
2021 ◽  
Vol 147 (5) ◽  
pp. e2020022301
Author(s):  
Darren Klawinski ◽  
Issa Hanna ◽  
Nathaniel K. Breslin ◽  
Howard M. Katzenstein ◽  
Daniel J. Indelicato
Keyword(s):  
Young Adult ◽  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Electronic Cigarette ◽  
Cigarette Use

scholarly journals Degree of Acidity, Salivary Flow Rate and Caries Index in Electronic Cigarette Users in Sleman Regency, Indonesia

2020 ◽  
Vol 3 (1) ◽  
pp. 37
Author(s):  
Dyah Ayu Lestari ◽  
Regina TC. Tandelilin ◽  
Friska Ani Rahman
Keyword(s):  
Oral Cavity ◽  
Flow Rate ◽  
Electronic Cigarettes ◽  
Salivary Flow ◽  
The Body ◽  
Electronic Cigarette ◽  
Salivary Flow Rate ◽  
Cigarette Smokers ◽  
Flow Rates ◽  
Significant Difference

Introduction: The Yogyakarta Special Region ranks sixth for highest number of smokers of the 33 provinces in Indonesia. Smokers account for 31.6% of the total population. Sleman Regency ranks fourth in daily consumption of cigarettes of the five regencies or cities in Yogyakarta. The body part most exposed to direct cigarette smoke is the oral cavity. Saliva is a liquid secreted inside the oral cavity to act as a buffer. Nicotine content in conventional cigarettes is known to diminish the salivary flow rate and the acidity (pH) of the saliva. A continual decrease in saliva pH over time may cause dental caries. The use of electronic cigarettes is a nicotine replacement therapy (NRT) method to help people quit smoking; they emit a lower nicotine level than conventional cigarettes. Objective: The aim of this study was to evaluate the saliva pH, salivary flow rates, and caries index of electronic cigarette smokers. Methods: This study used a cross-sectional method to compare the saliva pH, salivary flow rate, and caries index of 30 smokers of electronic cigarettes and 30 non-smokers as a control group. Data were analyzed using SPSS version 22.0 software and considered statistically significant at p < 0.05. Results: The Mann-Whitney analysis showed a significant difference in the saliva pH between electronic cigarette smokers and non-smokers. Independent T-Test analysis showed no significant difference in the salivary flow rates of the two groups. The Mann-Whitney analysis also showed no significant difference in the caries index of the groups. Conclusion: Results indicated that there is a significant difference in the saliva pH of electronic cigarette smokers, while the salivary flow rates and caries indices of electronic cigarette smokers and non-smokers were similar.

Preoperative prognostic nutritional index predicts prognosis of patients with oral cavity cancer

Oral Diseases ◽  
2021 ◽  
Author(s):  
Ku‐Hao Fang ◽  
Sheng‐Wei Chang ◽  
Yi‐Chan Lee ◽  
Ethan I Huang ◽  
Chia‐Hsuan Lai ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Prognostic Nutritional Index ◽  
Nutritional Index

79 Electronic Cigarette-Related Injuries Presenting to Five Large Burn Centers, 2015–2019

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S54-S55
Author(s):  
Carmen E Flores ◽  
Paul J Chestovich ◽  
Syed F Saquib ◽  
Joseph T Carroll ◽  
Mariam Al-Hamad Daubs ◽  
...  
Keyword(s):  
Thermal Injury ◽  
Spontaneous Combustion ◽  
Electronic Cigarettes ◽  
Total Body Surface Area ◽  
Public Health Problem ◽  
Electronic Cigarette ◽  
Outpatient Basis ◽  
Burn Centers ◽  
Split Thickness Skin Grafting ◽  
Inpatient Basis

Abstract Introduction Electronic cigarettes are advertised as safer alternatives to smoking cigarettes yet can cause serious injury. As consumer use of electronic cigarettes has increased, burn centers have witnessed a rise in both inpatient and outpatient visits to treat thermal and blast injuries related to their use. Methods A multicenter retrospective chart review of ABA burn registry data from 5 large burn centers was performed from January 2015 to July 2019 to identify patients who sustained Electronic Nicotine Delivery Systems (ENDS)-related injuries. Results A total of 127 patients with electronic cigarette-related injuries were identified, of which 113 were male (89%) and 14 were female (11%). Mean age was 34.0 years (SD 13.5%, range 1–75 years). The majority of patients (n=92, 72%) were treated on an inpatient basis, and average length of stay was 6.7 days. Most patients sustained less than 10% total body surface area burns (mean 3.8%, SD 2.6%, range 0.1% to 16.5%). 66% (n=85) sustained 2nd degree burns, and 36% (n=46) sustained 3rd degree burns. Most patients were injured while using the ENDS (n=100, 78%), while 18% (n=24) of patients reported spontaneous combustion. 2 patients (1.5%) were injured while changing their device battery, and 2 patients (1.5%) were injured while modifying the device. 3% (n=4) were injured by second-hand mechanism. Burn injury was the most common injury pattern (100%), followed by blast injury (n=81, 63%). Flame burns were the most common (n=89, 70%) type of thermal injury, followed by contact burns (n= 70, 55%), flash burns (n=47, 37%), chemical burns (n=2, 1.5%), and electrical burns (n=1, 0.7%). The most commonly injured body region was the extremities. There were no ENDS-related deaths. Silvadene was the most common topical agent used in the initial management of thermal injuries, followed by Bacitracin and Xeroform. 63% (n=80) of patients did not require surgery, while 36% (n=46) required surgical excision, and 15% (n=20) required split-thickness skin grafting. Multiple surgeries were uncommon. 22% of patients required one operation, 12% required two operations, and 2% required 3 operations. Conclusions Our data recognizes use of ENDS as a growing public health problem with potential to cause thermal injury and secondary trauma. Most injuries occur during use, however many result from spontaneous combustion while the device is not being used. Treatment of ENDS-related injuries is institution-dependent. Most patients are treated on an inpatient basis however the majority of patients treated on outpatient basis have good outcomes.

scholarly journals Translation of c-Met Targeted Image-Guided Surgery Solutions in Oral Cavity Cancer—Initial Proof of Concept Data

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2674
Author(s):  
Tessa Buckle ◽  
Maarten van Alphen ◽  
Matthias N. van Oosterom ◽  
Florian van Beurden ◽  
Nina Heimburger ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Ex Vivo ◽  
Intermediate Step ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Tumor Identification ◽  
Imaging Results ◽  
Pathological Evaluation ◽  
Fluorescence Camera

Intraoperative tumor identification (extension/margins/metastases) via receptor-specific targeting is one of the ultimate promises of fluorescence-guided surgery. The translation of fluorescent tracers that enable tumor visualization forms a critical component in the realization of this approach. Ex vivo assessment of surgical specimens after topical tracer application could help provide an intermediate step between preclinical evaluation and first-in-human trials. Here, the suitability of the c-Met receptor as a potential surgical target in oral cavity cancer was explored via topical ex vivo application of the fluorescent tracer EMI-137. Freshly excised tumor specimens obtained from ten patients with squamous cell carcinoma of the tongue were incubated with EMI-137 and imaged with a clinical-grade Cy5 prototype fluorescence camera. In-house developed image processing software allowed video-rate assessment of the tumor-to-background ratio (TBR). Fluorescence imaging results were related to standard pathological evaluation and c-MET immunohistochemistry. After incubation with EMI-137, 9/10 tumors were fluorescently illuminated. Immunohistochemistry revealed c-Met expression in all ten specimens. Non-visualization could be linked to a more deeply situated lesion. Tumor assessment was improved via video representation of the TBR (median TBR: 2.5 (range 1.8–3.1)). Ex vivo evaluation of tumor specimens suggests that c-Met is a possible candidate for fluorescence-guided surgery in oral cavity cancer.

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