Prognostic Factors for Survival in Patients with Oral Cavity Cancer: A Comparison of the Netherlands and Taiwan Using Privacy-Preserving Federated Analyses

2020 ◽  
Author(s):  
G. Geleijnse ◽  
RuRu Chun-Ju Chiang ◽  
Melle Sieswerda ◽  
Melinda Schuurman ◽  
KC Lee ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
The Netherlands ◽  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Privacy Preserving

scholarly journals Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Gijs Geleijnse ◽  
RuRu Chun-Ju Chiang ◽  
Melle Sieswerda ◽  
Melinda Schuurman ◽  
K. C. Lee ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
The Netherlands ◽  
Oral Cavity ◽  
Cancer Registry ◽  
Hospital Volume ◽  
Oral Cavity Cancer ◽  
Lower Grade ◽  
Risk Of Death ◽  
Patient Level ◽  
Netherlands Cancer Registry

AbstractThe difference in incidence of oral cavity cancer (OCC) between Taiwan and the Netherlands is striking. Different risk factors and treatment expertise may result in survival differences between the two countries. However due to regulatory restrictions, patient-level analyses of combined data from the Netherlands and Taiwan are infeasible. We implemented a software infrastructure for federated analyses on data from multiple organisations. We included 41,633‬ patients with single-tumour OCC between 2004 and 2016, undergoing surgery, from the Taiwan Cancer Registry and Netherlands Cancer Registry. Federated Cox Proportional Hazard was used to analyse associations between patient and tumour characteristics, country, treatment and hospital volume with survival. Five factors showed differential effects on survival of OCC patients in the Netherlands and Taiwan: age at diagnosis, stage, grade, treatment and hospital volume. The risk of death for OCC patients younger than 60 years, with advanced stage, higher grade or receiving adjuvant therapy after surgery was lower in the Netherlands than in Taiwan; but patients older than 70 years, with early stage, lower grade and receiving surgery alone in the Netherlands were at higher risk of death than those in Taiwan. The mortality risk of OCC in Taiwanese patients treated in hospitals with higher hospital volume (≥ 50 surgeries per year) was lower than in Dutch patients. We conducted analyses without exchanging patient-level information, overcoming barriers for sharing privacy sensitive information. The outcomes of patients treated in the Netherlands and Taiwan were slightly different after controlling for other prognostic factors.

Early oral cavity cancer: The prognostic factors and impact of adjuvant radiation on survival

Head & Neck ◽  
2019 ◽  
Vol 41 (10) ◽  
pp. 3577-3583 ◽  
Author(s):  
Suhas K. Rajappa ◽  
Udip Maheshwari ◽  
Dharma Ram ◽  
Venkata P. B. Koyyala ◽  
Ghanashyam Mandal ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Adjuvant Radiation

scholarly journals Trends in oral cavity cancer incidence, mortality, survival and treatment in the Netherlands

2016 ◽  
Vol 139 (3) ◽  
pp. 574-583 ◽  
Author(s):  
Boukje A.C. van Dijk ◽  
Marieke T. Brands ◽  
Sandra M.E. Geurts ◽  
Matthias A.W. Merkx ◽  
Jan L.N. Roodenburg
Keyword(s):  
The Netherlands ◽  
Oral Cavity ◽  
Cancer Incidence ◽  
Oral Cavity Cancer

Prognostic factors in oral cavity cancer with skull base recurrence

2011 ◽  
Vol 38 (2) ◽  
pp. 266-270 ◽  
Author(s):  
Ik Joon Choi ◽  
Ji-Hun Mo ◽  
Soon-Hyun Ahn
Keyword(s):  
Prognostic Factors ◽  
Oral Cavity ◽  
Skull Base ◽  
Oral Cavity Cancer

Contralateral lymph node recurrence rate and its prognostic factors in stage IVA-B well-lateralized oral cavity cancer

2021 ◽  
Author(s):  
Ju-Chun Chien ◽  
Yu-Chang Hu ◽  
Kuo-Chen Chang ◽  
Yu-Hsien Huang ◽  
Chien-Yu Huang ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Oral Cavity ◽  
Recurrence Rate ◽  
Oral Cavity Cancer ◽  
Lymph Node Recurrence
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