scholarly journals Stiff Man Syndrome: A Diagnostic Dilemma in a Young Female with Diabetes Mellitus and Thyroiditis

2014 ◽  
Vol 7 ◽  
pp. CCRep.S16941 ◽  
Author(s):  
Hilary Enuh ◽  
Michael Park ◽  
Arjun Ghodasara ◽  
Edward Arsura ◽  
Jay Nfonoyim
Keyword(s):  
Diabetes Mellitus ◽  
Young Female ◽  
Leg Pain ◽  
Stiff Person Syndrome ◽  
Diagnostic Dilemma ◽  
Lower Extremity Weakness ◽  
Unsteady Gait ◽  
Unusual Occurrence ◽  
Stiff Man Syndrome

Stiff Person Syndrome (SPS), is a very rare neuroimmunologic disorder characterized by progressive muscle pain, rigidity, stiffness, and spasms. It can be very debilitating if misdiagnosed or not recognized in time. Herein we discuss a case of a female in her 20s who presented with an unsteady gait, lower extremity weakness, persistent leg pain, and stiffness few weeks after uncomplicated childbirth. She has type 1 diabetes mellitus (DM) and was diagnosed with thyroiditis in the course of her illness. The triad of thyroiditis, DM, and stiffness with normal neuroimaging in a young female patient is an unusual occurrence.

scholarly journals Stiff-person syndrome and type 1 diabetes mellitus

2016 ◽  
Author(s):  
Antonio F Oliveira Filho ◽  
Rossana C Almeida ◽  
Eveline M C Brito ◽  
Adriana B Nunes
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Stiff Person Syndrome

Stiff - person syndrome in an old woman with late onset type 1 diabetes mellitus

2018 ◽  
Author(s):  
Maria Florencia Luchtenberg ◽  
Ismael Capel ◽  
Isabel Mazarico ◽  
Albert Cano ◽  
Lara Albert ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Late Onset ◽  
Stiff Person Syndrome ◽  
Onset Type

Immune reactivity to glutamic acid decarboxylase 65 in stiff-man syndrome and type 1 diabetes mellitus

The Lancet ◽  
2000 ◽  
Vol 356 (9223) ◽  
pp. 31-35 ◽  
Author(s):  
Tobias Lohmann ◽  
Mohammed Hawa ◽  
R David G Leslie ◽  
Russell Lane ◽  
Jean Picard ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glutamic Acid ◽  
Type 1 Diabetes Mellitus ◽  
Glutamic Acid Decarboxylase ◽  
Acid Decarboxylase ◽  
Immune Reactivity ◽  
Stiff Man Syndrome ◽  
Glutamic Acid Decarboxylase 65

169-LB: Type 1 Diabetes Mellitus and Stiff-Person Syndrome

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 169-LB
Author(s):  
CÁTIA A. ARAÚJO ◽  
CARLA BAPTISTA ◽  
ISABEL PAIVA ◽  
ANA MORGADINHO
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Stiff Person Syndrome

scholarly journals Glycogenic hepatopathy as a cause of severe deranged liver enzymes in a young patient with type 1 diabetes mellitus

2019 ◽  
Vol 12 (3) ◽  
pp. e228524
Author(s):  
Kalliopi Azariadis ◽  
Nikolaos K Gatselis ◽  
George K Koukoulis ◽  
Georgios N Dalekos
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Acute Hepatitis ◽  
Type 1 Diabetes Mellitus ◽  
Rare Complication ◽  
Abrupt Onset ◽  
Young Female ◽  
The Right

Glycogenic hepatopathy (GH) is a rare complication of poorly controlled type 1 diabetes mellitus (T1DM). We present a 19-year-old woman with T1DM and autoimmune thyroiditis who admitted to our department because of abrupt onset intermittent abdominal pain in the right upper quadrant accompanied by laboratory evidence of acute anicteric hepatitis. Physical examination revealed significant hepatomegaly but the common imagining studies were negative. Following exclusion of common causes of acute hepatitis and because of the presence of smooth muscle antibodies in a young female patient with already established two autoimmune diseases, a liver biopsy was performed in order to exclude the potential presence of autoimmune hepatitis. However, liver histology showed typical findings of GH. Intense treatment targeting strict glycemic control resulted in normalisation of liver biochemistry. This case underlines that GH should be considered as a rare cause of acute hepatitis in T1DM patients with poor glycemic control.

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