scholarly journals Reduced display of conformational epitopes in the N‐terminal truncated GAD 65 isoform: relevance for people with stiff person syndrome or DQ 8/8‐positive Type 1 diabetes mellitus

2018 ◽  
Vol 36 (11) ◽  
pp. 1375-1383 ◽  
Author(s):  
C. S. Hampe ◽  
J. R. Radtke ◽  
A. Wester ◽  
A. Carlsson ◽  
E. Cedervall ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Stiff Person Syndrome ◽  
Positive Type ◽  
Conformational Epitopes ◽  
Gad 65

The prevalence, immune profile, and clinical characteristics of children with celiac disease and type 1 diabetes mellitus in the state of Qatar

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Basma Haris ◽  
Ahmed Abdellatief ◽  
Houda Afyouni ◽  
Tasneem Abdel-Karim ◽  
Shayma Mohammed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Characteristics ◽  
Family History Of Diabetes ◽  
Positive Type ◽  
Immune Profile ◽  
Insulin Autoantibody

Abstract Objectives Children with antibody positive type 1 diabetes mellitus (type 1 diabetes) are at an increased risk of developing celiac disease (CD) which suggests a common autoimmune basis with both high-risk human lymphocyte antigen (HLA) and non-HLA factors playing a role in the pathophysiology. We aim to describe the prevalence, immune profile, and clinical characteristics of children with CD who have type 1 diabetes mellitus in Qatar. Methods All children (aged 0–18 years) attending a regional diabetes clinic with antibody positive type 1 diabetes were screened for CD. Measurement of tissue transglutaminase IgA and IgG as well as anti-endomysial antibody, was done, clinical details about the birth history, family history of diabetes and CD, age of onset, and ethnicity were collected. Results Out of the 1,325 children with antibody positive type 1 diabetes, 54 were identified to have CD on screening and then confirmed on small bowel biopsy. The prevalence of CD in the type 1 diabetes childhood population in Qatar is 4.07%. CD and type 1 diabetes were more prevalent in the Qatari children (n=32) as compared to non-Qatari (n=22) and occurred mostly in the age group 6–10 years. The most common type 1 diabetes antibodies in children with CD were glutamic acid decarboxylase and insulin autoantibody. Twelve subjects were asymptomatic for CD symptoms and picked up only on screening. Conclusions The prevalence of CD in children with type 1 diabetes in Qatar is comparable to reports from around the world. Many children were asymptomatic and thus routine screening is recommended.

scholarly journals Stiff-person syndrome and type 1 diabetes mellitus

2016 ◽  
Author(s):  
Antonio F Oliveira Filho ◽  
Rossana C Almeida ◽  
Eveline M C Brito ◽  
Adriana B Nunes
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Stiff Person Syndrome

Stiff - person syndrome in an old woman with late onset type 1 diabetes mellitus

2018 ◽  
Author(s):  
Maria Florencia Luchtenberg ◽  
Ismael Capel ◽  
Isabel Mazarico ◽  
Albert Cano ◽  
Lara Albert ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Late Onset ◽  
Stiff Person Syndrome ◽  
Onset Type

169-LB: Type 1 Diabetes Mellitus and Stiff-Person Syndrome

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 169-LB
Author(s):  
CÁTIA A. ARAÚJO ◽  
CARLA BAPTISTA ◽  
ISABEL PAIVA ◽  
ANA MORGADINHO
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Stiff Person Syndrome

Rare presentation of anti-GAD-65 antibody-positive autoimmune encephalitis and simultaneous onset of type 1 diabetes mellitus in a paediatric patient

2021 ◽  
Vol 14 (3) ◽  
pp. e237913
Author(s):  
Kristina Kern ◽  
Brooke A Shuster
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Brain Mri ◽  
Autoimmune Encephalitis ◽  
Acid Decarboxylase ◽  
Rare Presentation ◽  
Gad 65 ◽  
Gad 65 Antibodies

A 16-year-old female patient presented with subacute onset of headaches, changes in acute mental status, expressive aphasia and auditory hallucinations. New oedema and enhancement of the temporal lobe were seen on brain MRI, with correlating subclinical seizures seen on electroencephalogram. Simultaneously, our patient was diagnosed with new-onset type 1 diabetes mellitus, with positive anti-glutamic acid decarboxylase (anti-GAD-65) antibodies in the serum. Cerebrospinal fluid studies remained negative, including anti-GAD-65 antibodies. Clinical remission was achieved with corticosteroids and intravenous immunoglobulins.

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