scholarly journals Methodology for Constructing Problem Definitions in Bioinformatics

2008 ◽  
Vol 2 ◽  
pp. BBI.S706
Author(s):  
Amy M. Hauth ◽  
Gertraud Burger

Motivation A recurrent criticism is that certain bioinformatics tools do not account for crucial biology and therefore fail answering the targeted biological question. We posit that the single most important reason for such shortcomings is an inaccurate formulation of the computational problem. Results Our paper describes how to define a bioinformatics problem so that it captures both the underlying biology and the computational constraints for a particular problem. The proposed model delineates comprehensively the biological problem and conducts an item-by-item bioinformatics transformation resulting in a germane computational problem. This methodology not only facilitates interdisciplinary information flow but also accommodates emerging knowledge and technologies.

Author(s):  
Zahir Tari ◽  
Peter Bertok ◽  
Dusan Simic

Information Flow Control (IFC) is a method of enforcing confidentiality by using labels, data structures for specifying security classifications. IFC is used in programming languages to monitor procedures in an attempt to detect and prevent information leakage. While it ensures greater security, IFC excessively restricts flow of information. This chapter presents a model of information flow control using semi-discretionary label structures. We propose a set of rules that not only increase the flexibility of IFC, but also define labels as a practical component of a security system. We propose a dynamic approach using a centralized model for dynamic label checking, and verify the proposed model using theoretical proofs.


2022 ◽  
Vol 7 ◽  
Author(s):  
Müge Tetik ◽  
Antti Peltokorpi ◽  
Olli Seppänen ◽  
Jan Holmström

Logistics practices are processes that require alignment and coordination among project actors to support successful construction operations. While recent research has underlined the effects of single material logistics practices on project performance, practitioners need more knowledge on development paths toward successful overall logistics solutions. Based on a review of current practices obtained from the literature, this research proposes the maturity levels of planning, organizing, operating, use of technology, and information flow regarding the logistics practices in construction. Moreover, the study devises a recommended order for implementing logistics practices and investigates how companies can advance their logistics maturity from one level to the next. The proposed model has been validated via case examples from the industry. The paper contributes to construction logistics research by describing how companies can navigate development efforts to gradually improve their logistics practices. Future research could conduct more case studies within different project contexts.


Author(s):  
D.G. SHIN ◽  
J. LEONE

This work explores a distributed problem solving (DPS) approach, namely the AM/AG (Amplification/Aggregation) model. The AM/AG model is a hierarchic social system metaphor for DPS based on Mintzberg’s model of organizations. At the core of the model are information flow mechanisms, namely, amplification and aggregation. Amplification is a process of decomposing a given task, called an agenda, into a set of subtasks with magnified degree of specificity and distributing them to multiple processing units downward in the hierarchy. Aggregation is a process of combining the results reported from multiple processing units into a unified view, called a resolution, and promoting the conclusion upward in the hierarchy. Amplification is discussed in detail. A set of generative rules is introduced. Each rule specifies a set of actions for transforming an input agenda into other forms with higher specificity. The proposed model can be used to account for the memory recall process which makes associations between vast amounts of related concepts, sorts out the combined results, and promotes the most plausible ones. An example of memory recall is used to illustrate the model.


Author(s):  
D.P. Bazett-Jones ◽  
F.P. Ottensmeyer

It has been shown for some time that it is possible to obtain images of small unstained proteins, with a resolution of approximately 5Å using dark field electron microscopy (1,2). Applying this technique, we have observed a uniformity in size and shape of the 2-dimensional images of pure specimens of fish protamines (salmon, herring (clupeine, Y-l) and rainbow trout (Salmo irideus)). On the basis of these images, a model for the 3-dimensional structure of the fish protamines has been proposed (2).The known amino acid sequences of fish protamines show stretches of positively charged arginines, separated by regions of neutral amino acids (3). The proposed model for protamine structure (2) consists of an irregular, right-handed helix with the segments of adjacent arginines forming the loops of the coil.


2010 ◽  
Vol 15 (2) ◽  
pp. 121-131 ◽  
Author(s):  
Remus Ilies ◽  
Timothy A. Judge ◽  
David T. Wagner

This paper focuses on explaining how individuals set goals on multiple performance episodes, in the context of performance feedback comparing their performance on each episode with their respective goal. The proposed model was tested through a longitudinal study of 493 university students’ actual goals and performance on business school exams. Results of a structural equation model supported the proposed conceptual model in which self-efficacy and emotional reactions to feedback mediate the relationship between feedback and subsequent goals. In addition, as expected, participants’ standing on a dispositional measure of behavioral inhibition influenced the strength of their emotional reactions to negative feedback.


2020 ◽  
Vol 39 (3) ◽  
pp. 4041-4058
Author(s):  
Fang Liu ◽  
Xu Tan ◽  
Hui Yang ◽  
Hui Zhao

Intuitionistic fuzzy preference relations (IFPRs) have the natural ability to reflect the positive, the negative and the non-determinative judgements of decision makers. A decision making model is proposed by considering the inherent property of IFPRs in this study, where the main novelty comes with the introduction of the concept of additive approximate consistency. First, the consistency definitions of IFPRs are reviewed and the underlying ideas are analyzed. Second, by considering the allocation of the non-determinacy degree of decision makers’ opinions, the novel concept of approximate consistency for IFPRs is proposed. Then the additive approximate consistency of IFPRs is defined and the properties are studied. Third, the priorities of alternatives are derived from IFPRs with additive approximate consistency by considering the effects of the permutations of alternatives and the allocation of the non-determinacy degree. The rankings of alternatives based on real, interval and intuitionistic fuzzy weights are investigated, respectively. Finally, some comparisons are reported by carrying out numerical examples to show the novelty and advantage of the proposed model. It is found that the proposed model can offer various decision schemes due to the allocation of the non-determinacy degree of IFPRs.


Author(s):  
Honghai LI ◽  
Jun CAI

The transformation of China's design innovation industry has highlighted the importance of design research. The design research process in practice can be regarded as the process of knowledge production. The design 3.0 mode based on knowledge production MODE2 has been shown in the Chinese design innovation industry. On this cognition, this paper establishes a map with two dimensions of how knowledge integration occurs in practice based design research, which are the design knowledge transfer and contextual transformation of design knowledge. We use this map to carry out the analysis of design research cases. Through the analysis, we define four typical practice based design research models from the viewpoint of knowledge integration. This method and the proposed model can provide a theoretical basis and a path for better management design research projects.


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