scholarly journals Tissue-specific Role of CX3CR1 Expressing Immune Cells and Their Relationships with Human Disease

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Myoungsoo Lee ◽  
Yongsung Lee ◽  
Jihye Song ◽  
Junhyung Lee ◽  
Sun-Young Chang
Keyword(s):  
Immune Cells ◽  
Human Disease ◽  
Specific Role ◽  
Tissue Specific

scholarly journals Tissue-specific Role of the Na,K-ATPase α2 Isozyme in Skeletal Muscle

2012 ◽  
Vol 288 (2) ◽  
pp. 1226-1237 ◽  
Author(s):  
Tatiana L. Radzyukevich ◽  
Jonathon C. Neumann ◽  
Tara N. Rindler ◽  
Naomi Oshiro ◽  
David J. Goldhamer ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Specific Role ◽  
Tissue Specific

scholarly journals The tissue specific role of SirT1 in joint inflammation and anabolic cartilage gene expression

2015 ◽  
Vol 23 ◽  
pp. A33
Author(s):  
P.K. Sacitharan ◽  
J. Zarebska ◽  
A. Chanalaris ◽  
G. Bou Gharios ◽  
E. J ◽  
...  
Keyword(s):  
Gene Expression ◽  
Joint Inflammation ◽  
Specific Role ◽  
Tissue Specific

scholarly journals Regulation of KLF4 Turnover Reveals an Unexpected Tissue-Specific Role of pVHL in Tumorigenesis

2012 ◽  
Vol 45 (2) ◽  
pp. 233-243 ◽  
Author(s):  
Armin M. Gamper ◽  
Xinxian Qiao ◽  
Jennifer Kim ◽  
Liyong Zhang ◽  
Michelle C. DeSimone ◽  
...  
Keyword(s):  
Specific Role ◽  
Tissue Specific

scholarly journals Regulation of KLF4 Turnover Reveals an Unexpected Tissue-Specific Role of pVHL in Tumorigenesis

2015 ◽  
Vol 60 (2) ◽  
pp. 339
Author(s):  
Armin M. Gamper ◽  
Xinxian Qiao ◽  
Jennifer Kim ◽  
Liyong Zhang ◽  
Michelle C. DeSimone ◽  
...  
Keyword(s):  
Specific Role ◽  
Tissue Specific

Tissue-specific role of Nrf2 in the treatment of diabetic foot ulcers during hyperbaric oxygen therapy

2019 ◽  
Vol 138 ◽  
pp. 53-62 ◽  
Author(s):  
Umapathy Dhamodharan ◽  
Amin Karan ◽  
Dornadula Sireesh ◽  
Alladi Vaishnavi ◽  
Arumugam Somasundar ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Diabetic Foot ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Specific Role ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Tissue Specific

scholarly journals A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies

2019 ◽  
Author(s):  
Xingjie Shi ◽  
Xiaoran Chai ◽  
Yi Yang ◽  
Qing Cheng ◽  
Yuling Jiao ◽  
...  
Keyword(s):  
Complex Traits ◽  
Mixed Model ◽  
Target Genes ◽  
Association Studies ◽  
Specific Role ◽  
Tissue Specific ◽  
Candidate Target ◽  
Different Tissues ◽  
Trait Associations

AbstractTranscriptome-wide association studies (TWAS) integrate expression quantitative trait loci (eQTLs) studies with genome-wide association studies (GWASs) to prioritize candidate target genes for complex traits. Several statistical methods have been recently proposed to improve the performance of TWAS in gene prioritization by integrating the expression regulatory information imputed from multiple tissues, and made significant achievements in improving the ability to detect gene-trait associations. The major limitation of these methods is that they cannot be used to elucidate the specific functional effects of candidate genes across different tissues. Here, we propose a tissue-specific collaborative mixed model (TisCoMM) for TWAS, leveraging the co-regulation of genetic variations across different tissues explicitly via a unified probabilistic model. TisCoMM not only performs hypothesis testing to prioritize gene-trait associations, but also detects the tissue-specific role of candidate target genes in complex traits. To make use of widely available GWAS summary statistics, we extend TisCoMM to use summary-level data, namely, TisCoMM-S2. Using extensive simulation studies, we show that type I error is controlled at the nominal level, the statistical power of identifying associated genes is greatly improved, and false positive rate (FPR) for non-causal tissues is well controlled at decent levels. We further illustrate the benefits of our methods in applications to summary-level GWAS data of 33 complex traits. Notably, apart from better identifying potential trait-associated genes, we can elucidate the tissue-specific role of candidate target genes. The follow-up pathway analysis from tissue-specific genes for asthma shows that the immune system plays an essential function for asthma development in both thyroid and lung tissues.

scholarly journals Atherogenic Factors and Their Epigenetic Relationships

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Ana Z. Fernandez ◽  
Andrew L. Siebel ◽  
Assam El-Osta
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Dna Methylation ◽  
Smooth Muscle ◽  
Immune Cells ◽  
Human Disease ◽  
Physiology And Biochemistry ◽  
Histone Modifying Enzymes ◽  
Atherosclerotic Process

Hypercholesterolemia, homocysteine, oxidative stress, and hyperglycemia have been recognized as the major risk factors for atherogenesis. Their impact on the physiology and biochemistry of vascular cells has been widely demonstrated for the last century. However, the recent discovery of the role of epigenetics in human disease has opened up a new field in the study of atherogenic factors. Thus, epigenetic tags in endothelial, smooth muscle, and immune cells seem to be differentially affected by similar atherogenic stimuli. This paper summarizes some recent works on expression of histone-modifying enzymes and DNA methylation directly linked to the presence of risk factors that could lead to the development or prevention of the atherosclerotic process.

scholarly journals The Tissue Specific Role of Estrogen and Progesterone in Human Endometrium and Mammary Gland

10.5772/25815 ◽  
2012 ◽  
Author(s):  
Karin Tamm ◽  
Marina Suhorutshenko ◽  
Miia Rm ◽  
Jaak Simm ◽  
Madis Metsis
Keyword(s):  
Mammary Gland ◽  
Human Endometrium ◽  
Specific Role ◽  
Tissue Specific
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