Antiarthritic and antinociceptive potential of ethanolic extract from leaves of Doliocarpus dentatus (aubl.) standl. in mouse model

2021 ◽  
Vol 13 (1) ◽  
pp. 28
Author(s):  
MariaHelena Verdan ◽  
LidianeSchultz Branquinho ◽  
SauloEuclides Silva-Filho ◽  
RodrigoJuliano Oliveira ◽  
ClaudiaAndrea Lima Cardoso ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ethanolic Extract

Gynostemma pentaphyllum Ethanolic Extract Protects Against Memory Deficits in an MPTP-Lesioned Mouse Model of Parkinson's Disease Treated with L-DOPA

2017 ◽  
Vol 20 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Kyung Sook Kim ◽  
Ting Ting Zhao ◽  
Keon Sung Shin ◽  
Hyun Jin Park ◽  
Yoon Jeong Cho ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Ethanolic Extract ◽  
Memory Deficits ◽  
Gynostemma Pentaphyllum

scholarly journals Effect of Ethanolic Extract of Cayratia trifolia on Histologically Kidney Mouse Model

2020 ◽  
Vol 1665 ◽  
pp. 012023
Author(s):  
Djoko Santoso ◽  
I Ketut Sudiana ◽  
Anny Setijo Rahayu ◽  
Muchammad Yunus
Keyword(s):  
Mouse Model ◽  
Ethanolic Extract ◽  
Cayratia Trifolia

scholarly journals Comparative characterization of cinnamon, cinnamaldehyde and kaempferol for phytochemical, antioxidant and pharmacological properties using acetaminophen-induced oxidative stress mouse model

2021 ◽  
Vol 20 (4) ◽  
pp. 339-350
Author(s):  
Zulfia Hussain ◽  
◽  
Junaid Ali Khan ◽  
Muhammad Imran Arshad ◽  
Faqir Muhammad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Therapeutic Potential ◽  
Intraperitoneal Administration ◽  
Ethanolic Extract ◽  
Screening Tests ◽  
Bark Extract ◽  
Histopathological Analysis ◽  
Cinnamon Bark

This study was aimed to explore the comparative efficacy of cinnamon bark extract, cinnamaldehyde and kaempferol against acetaminophen (APAP)-induced oxidative stress. Cinnamon bark extract, cinnamaldehyde and kaempferol were utilized for in-vivo analysis. From the results of in-vitro screening tests, cinnamon ethanolic extract was selected for in-vivo study in mouse model. For this, Balb/c albino mice were treated with cinnamon ethanolic extract (200 mg/kg), cinnamaldehyde (10 mg/kg) and kaempferol (10 mg/kg) orally for 14 days followed by single intraperitoneal administration of APAP during 8 hours. Blood and organ samples were collected for biochemical and histopathological analysis. The results showed that cinnamon bark ethanolic extract, cinnamaldehyde and kaempferol ameliorated APAP-induced oxidative stress and organ toxicity in mice. In conclusion, cinnamaldehyde and kaempferol possess comparable antioxidant potential even at 20-times less dose as compared to cinnamon bark ethanolic extract suggesting therapeutic potential in oxidative stress-related disorders.

scholarly journals Gyogamdan, a Traditional Medicine Prescription, Ameliorated Dermal Inflammation and Hyperactive Behavior in an Atopic Dermatitis Mouse Model Exposed to Psychological Stress

2021 ◽  
Vol 2021 ◽  
pp. 1-18
Author(s):  
Ly Thi Huong Nguyen ◽  
Uy Thai Nguyen ◽  
Min-Jin Choi ◽  
Tae-Woo Oh ◽  
In-Jun Yang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Model ◽  
Traditional Medicine ◽  
Psychological Stress ◽  
Ethanolic Extract ◽  
Eosinophil Infiltration ◽  
Bv2 Cells ◽  
Tnf Α ◽  
Medicine Prescription

Psychological stress (PS) plays a significant role as an aggravating factor in atopic dermatitis (AD). The traditional medicine prescription, Gyogamdan, has been used to treat chest discomfort and mood disorders caused by PS. This study investigated the effects of an ethanolic extract of Gyogamdan (GGDE) on stress-associated AD models and the underlying mechanisms. 2,4-Dinitrochlorobenzene- (DNCB-) treated BALB/c mice were exposed to social isolation (SI) stress. The effects of orally administered GGDE (100 or 500 mg/kg) were evaluated by ELISA, western blotting, and an open field test (OFT). SI stress exaggerated the skin inflammation and induced locomotor hyperactivity in the AD mouse model. GGDE reduced the levels of IgE, TNF-α, IL-13, eotaxin, and VEGF and mast cell/eosinophil infiltration and prevented the decreases in the levels of involucrin and loricrin in the skin. GGDE also suppressed the SI-induced increases in corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosterone (CORT) in socially isolated AD mice. Furthermore, GGDE reduced traveling distances and mean speed significantly in the OFT. The in vitro experiments were performed using HaCaT, HMC-1, PC12, and BV2 cells. In the TNF-α/IFN-γ- (TI-) stimulated HaCaT cells, GGDE decreased the thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) production significantly by inhibiting p-STAT1 and NF-κB signaling. GGDE also reduced VEGF production in HMC-1 cells stimulated with CRH/substance P (SP) by inhibiting p-ERK signaling pathway. GGDE increased the cell viability significantly and suppressed apoptosis in CORT-stimulated PC12 cells. Moreover, GGDE suppressed the LPS-induced production of NO, TNF-α, IL-1β, and IL-6 in BV2 cells. These results suggest that GGDE might be useful in patients with AD, which is exacerbated by PS.

scholarly journals Protective effect of Moringa oleifera Lam. leaf extract against carbon tetrachloride-induced neuroinflammation in a mouse model of hepatic encephalopathy

2021 ◽  
Author(s):  
Samah M. Fathy ◽  
Mohammed S.M. Mohammed
Keyword(s):  
Hepatic Encephalopathy ◽  
Carbon Tetrachloride ◽  
Mouse Model ◽  
Experimental Model ◽  
Moringa Oleifera ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Brain Regions ◽  
Primary Response ◽  
Vehicle Group

Abstract Background Hepatic encephalopathy (HE) is a neuropsychiatric disorder associated with acute or chronic liver injury. Carbon tetrachloride (CCl4) is usually used as an experimental model for HE. The present study aimed to assess the neuroprotective impacts of Moringa oleifera Lam. leaf ethanolic extract (MOLE) against neurotoxicity in CCl4-induced mouse model of HE. Methods High-performance liquid chromatography (HPLC) analysis was used for the detection of marker compounds; rutin and β-sitosterol. Animals were divided into four groups; vehicle group, CCl4 treated group, MOLE treated group, and (CCl4 + MOLE) group treated with MOLE for 14 days before inducing neurotoxicity by CCl4. Results Pretreatment with MOLE decreased alanine aminotransferase (ALT), aspartate aminotransferase (AST), corticosterone, and ammonia levels in serum as well as it improved the antioxidant status of CCl4 treated mice in the tissue of hippocampus (HC) and cerebral cortex (CC). It reduced the expression of toll-like receptor (TLR)4, TLR2, myeloid differentiation primary response 88 (MYD88), and nuclear factor kappa B (NF-κB) genes and the protein levels of the pro-inflammatory cytokines in the selected brain regions. MOLE also exhibited anti-apoptotic effect as revealed by the reduced expression of caspase3, and prevented histological deteriorations caused by CCl4 treatment. Furthermore, CCl4-induced anxiety and depression-like behavioral changes were attenuated by MOLE preadministration. Conclusions Taken together, the current results suggest significant anxiolytic and antidepressant effects of MOLE via modulation of neuroinflammation, oxidative stress, TLR4/2-MyD88/NF-κB pathway, and apoptosis in HE experimental model.

scholarly journals Anti-inflammatory Effect of Zostera marina Ethanolic Extract on LPS-induced RAW264.7 Cells and Mouse Model

KSBB Journal ◽  
2015 ◽  
Vol 30 (4) ◽  
pp. 182-190 ◽  
Author(s):  
Min-Ji Kim ◽  
Nan-Young Bae ◽  
Koth-Bong-Woo-Ri Kim ◽  
Ji-Hye Park ◽  
Sun-Hee Park ◽  
...  
Keyword(s):  
Mouse Model ◽  
Zostera Marina ◽  
Ethanolic Extract ◽  
Raw264.7 Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2361 ◽  
Author(s):  
Alejandro Ardiles ◽  
Ruth Barrientos ◽  
Mario Simirgiotis ◽  
Jorge Bórquez ◽  
Beatriz Sepúlveda ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mouse Model ◽  
Atacama Desert ◽  
Ethanolic Extract ◽  
Biologically Active ◽  
Gastroprotective Activity ◽  
Control Drug ◽  
Orbitrap Mass Spectrometry ◽  
Clerodane Diterpenes ◽  
First Time

Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant.

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