scholarly journals Ethanolic Extract of Traditional Chinese Medicine (TCM) Gamboge Inhibits Colon Cancer via the Wnt/Beta-Catenin Signaling Pathway in an Orthotopic Mouse Model

2018 ◽  
Vol 38 (4) ◽  
Keyword(s):  
Colon Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Mouse Model ◽  
Signaling Pathway ◽  
Ethanolic Extract ◽  
Beta Catenin ◽  
Orthotopic Mouse Model

scholarly journals Pseudo-allergic reaction caused by Qingkailing injection partially via the PI3K-Rac1 signaling pathway in RBL-2H3 cells

2019 ◽  
Vol 8 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Qin Li ◽  
Lingxi Zhang ◽  
Lili Gu ◽  
Bo Zhang ◽  
Jiaqi Lu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Allergic Reaction ◽  
Signaling Pathway ◽  
Qingkailing Injection

Qingkailing injection (QKLI) is a kind of multi-component traditional Chinese medicine injection.

scholarly journals Small Molecule Antagonists of the Wnt/Beta-Catenin Signaling Pathway Target Breast Tumor-Initiating Cells in a Her2/Neu Mouse Model of Breast Cancer

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33976 ◽  
Author(s):  
Robin M. Hallett ◽  
Maria K. Kondratyev ◽  
Andrew O. Giacomelli ◽  
Allison M. L. Nixon ◽  
Adele Girgis-Gabardo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Signaling Pathway ◽  
Small Molecule ◽  
Breast Tumor ◽  
Beta Catenin ◽  
Tumor Initiating Cells

scholarly journals Study on the Mechanism of Lianpu Drink for the Treatment of Chronic Gastritis Based on Network Pharmacology

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Shuhan Zhou ◽  
Yanjun Duan ◽  
Yu Deng ◽  
Miao Wang ◽  
Chaoqun Huang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Signaling Pathway ◽  
Chronic Gastritis ◽  
Mechanisms Of Action ◽  
Network Pharmacology ◽  
Biological Pathway ◽  
Disease Network ◽  
Target Disease ◽  
Compound Target

Chronic gastritis (CG) places a considerable burden on the healthcare system worldwide. Traditional Chinese Medicine (TCM) formulas characterized by multicompounds and multitargets have been acknowledged with striking effects in the treatment of CG in China’s history. Nevertheless, their accurate mechanisms of action are still ambiguous. In this study, we analyzed the effective compounds, potential targets, and related biological pathway of Lianpu Drink (LPD), a TCM formula which has been reported to have a therapeutic effect on CG, by contrasting a “compound-target-disease” network. According to the results, 92 compounds and 5762 putative targets of LPD were screened; among them, 8 compounds derived from different herbs in LPD and 30 common targets related to LPD and CG were selected as candidate compounds and precision targets, respectively. Meanwhile, the predicted common targets were verified by Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway analysis and pharmacological experiments. The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and β-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins. The study provides evidence for the mechanism of understanding of LPD for the treatment of CG.

scholarly journals Effect of Rhizoma Paridis saponin on the pain behavior in a mouse model of cancer pain

RSC Advances ◽  
2018 ◽  
Vol 8 (31) ◽  
pp. 17060-17072 ◽  
Author(s):  
Genbei Wang ◽  
Yuanxue Liu ◽  
Yu Wang ◽  
Wenyuan Gao
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Mouse Model ◽  
Cancer Pain ◽  
Pain Behavior ◽  
Cancer Drug ◽  
Anti Cancer

Rhizoma Paridis saponins (RPS) as active parts ofP. polyphyllaSmith var.yunnanensishas been used as an anti-cancer drug in traditional Chinese medicine.

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