Targeted delivery of curcumin using MgONPs and solid lipid nanoparticles: Attenuates aluminum.induced neurotoxicity in albino rats

2020 ◽  
Vol 12 (4) ◽  
pp. 380
Author(s):  
JohnSushma Nannepaga ◽  
Swathi Ganna ◽  
RajasekharaReddy Gutturu ◽  
Rajesh Megala ◽  
Rasajna Nadella ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Albino Rats ◽  
Solid Lipid

scholarly journals HIBISCUS ROSA SINENSIS LOADED SOLID LIPID NANOPARTICLES AND IN VIVO WOUND HEALING ACTIVITY IN WISTAR ALBINO RATS

2020 ◽  
pp. 78-83
Author(s):  
VIJAYANAND P. ◽  
JYOTHI V. ◽  
MOUNIKA A.
Keyword(s):  
Wound Healing ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Albino Rats ◽  
Herbal Extracts ◽  
Solid Lipid ◽  
Hibiscus Rosa Sinensis ◽  
Wistar Albino Rats ◽  
Wound Healing Activity

Objective: The objective of the present research was to investigate the wound-healing potency of solid lipid nano particles of Hibiscus rosa sinensis extract. Crude herbal extracts and rudimentary formulations containing herbal extracts are good for demonstrating the feasibility of the concept; however, such formulations suffer with poor oral bioavailability and variability within groups of subjects. Converting herbal extracts into novel drug delivery systems may prove effective in addressing some of these problems. Methods: In the present study an attempt was made to develop Hibiscus rosa sinensis extract loaded solid lipid nanoparticles (HSLNs) using lipids glycerol monostearate (GMS) or beeswax. The prepared HSLNs were characterised for their size, surface charge and morphology. The optimized HSLNs were incorporated into Carbopol gel and tested for wound healing activity in male Wistar albino rats using excision wound model. Results: HSLNs of ~175 nm in size carrying negative charge were obtained with the optimised procedure using beeswax. The shape of the HSLNs was nearly spherical. The HSLNs (10 mg/ml) treated wounds healed much faster compared to raw crude extract and healing was comparable to marketed preparation. Conclusion: It is concluded that converting crude herbal extracts into SLNs can be an effective way to enhance the effectiveness of herbal extracts and their in vivo activity.

Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells

2014 ◽  
Vol 114 ◽  
pp. 407-415 ◽  
Author(s):  
Tuan Hiep Tran ◽  
Ju Yeon Choi ◽  
Thiruganesh Ramasamy ◽  
Duy Hieu Truong ◽  
Chien Ngoc Nguyen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals Tumor-Targeted Delivery of Paclitaxel Using Low Density Lipoprotein-Mimetic Solid Lipid Nanoparticles

2015 ◽  
Vol 12 (4) ◽  
pp. 1230-1241 ◽  
Author(s):  
Jin-Ho Kim ◽  
Youngwook Kim ◽  
Ki Hyun Bae ◽  
Tae Gwan Park ◽  
Jung Hee Lee ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Nanoparticles ◽  
Low Density ◽  
Solid Lipid

scholarly journals Formulation, Optimization and Pharmacodynamic Studies of Pioglitazone HCl Solid Lipid Nanoparticles

2021 ◽  
pp. 329-341
Author(s):  
Y. Indira Muzib ◽  
E. Ramya ◽  
Y. R. Ambedkar
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Reference Group ◽  
Test Group ◽  
Tween 80 ◽  
Lipid Nanoparticles ◽  
Control Group ◽  
Albino Rats ◽  
Placebo Control ◽  
Solid Lipid ◽  
Group I

Pioglitazone HCl is an oral anti-diabetic agent used for the treatment of diabetes mellitus type II. The aim of the present work is to evaluate the pharmacodynamic activity of solid lipid nanoparticles of pioglitazone HCL prepared by using solvent injection technique and to compare with the control and test group. Among all the formulations, F5 was found to possess highest in-vitro drug release within 24 hrs i.e., 95.02±1.26%. The in vivo studies were performed using male albino rats of wistar strain (150-200g). Rats were divided in to five groups (n=6), group-I normal, group-II diabetes control, group-III   placebo control, group-IV reference, group-V test group. Diabetes was induced by streptazocin (60 mg/kg) by intraperitonial route. The reference group was treated with marketed tablet of pioglitazone HCL, test groups were treated with SLNs suspended in 0.1% Tween 80 and given to animals through oral gavages. Blood samples were collected by retro-orbital puncture before treatment, and after treatment at time intervals 0, 2, 4, 6, 8, 10, 12 and 24h in anti-coagulated vials. Parameters like glucose, tri glycerides (TG), total cholesterol (TC) and HDL-C were estimated by calorimetric method.  Diabetes induced rats showed elevated levels of glucose, TG, TC and reduced HDL. The oral administration of drug loaded SLNs in 0.1% Tween 80 solution showed reduced levels of glucose, TG and elevated levels of HDL-C and slightly reduced levels of TG in 24 h where as the marketed tablet showed reduced levels of glucose, TG and TC up-to 12 h and in 24thh  the glucose levels get elevated. Thus the optimized SLNs showed prolonged activity.

scholarly journals Targeted delivery of hyaluronic acid-coated solid lipid nanoparticles for rheumatoid arthritis therapy

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 716-722 ◽  
Author(s):  
Meiling Zhou ◽  
Jierong Hou ◽  
Zhirong Zhong ◽  
Na Hao ◽  
Yan Lin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals NEW DIRECTIONS IN THE CREATION OF INNOVATIVE ANTIPARASITIC DRUGS

2020 ◽  
pp. 72-80
Author(s):  
Varlamova ◽  
Arkhipov ◽  
Khalikov
Keyword(s):  
Supercritical Fluids ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Solid Dispersions ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
New Directions ◽  
Antiparasitic Drugs ◽  
Homogenization Methods ◽  
Manufacturing Technologies

A review of new directions in obtaining and manufacturing of innovative antiparasitic drugs is presented. The immobilization of antiparasitic drugs on or in nanoparticles to increase the efficacy and reduce side effects of drugs by improving the parameters of adsorption, bioavailability, slow release and intracellular permeability has been the most widespread direction in recent decades. Currently, such carriers as liposomes, polymer nanoparticles, solid lipid nanoparticles, nanosuspensions, nanocrystals, etc. are used as drug delivery systems for antiparasitic drugs. Studies conducted in our country have confirmed the efficacy of mechanochemical technology for producing solid dispersions of certain anthelmintic drugs (niclosamide, albendazole, fenbendazole, triclabendazole, praziquantel etc.) with excipients (arabinogalactan, polyvinylpyrrolidone, glycyrrhizic acid, etc.). On the example of solid lipid nanoparticles (SLN), the possibility and prospects of their further study and use as potential means of targeted delivery of antiparasitic drugs are shown, various manufacturing technologies are indicated, including homogenization methods, the use of supercritical fluids, the method of dry spray, evaporation, ultrasonic treatment, double emulsions, etc.

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