scholarly journals Tumor-Targeted Delivery of Paclitaxel Using Low Density Lipoprotein-Mimetic Solid Lipid Nanoparticles

2015 ◽  
Vol 12 (4) ◽  
pp. 1230-1241 ◽  
Author(s):  
Jin-Ho Kim ◽  
Youngwook Kim ◽  
Ki Hyun Bae ◽  
Tae Gwan Park ◽  
Jung Hee Lee ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Nanoparticles ◽  
Low Density ◽  
Solid Lipid

Cationic Solid Lipid Nanoparticles Reconstituted from Low Density Lipoprotein Components for Delivery of siRNA

2008 ◽  
Vol 5 (4) ◽  
pp. 622-631 ◽  
Author(s):  
Hyun Ryoung Kim ◽  
In Kyoung Kim ◽  
Ki Hyun Bae ◽  
Soo Hyeon Lee ◽  
Yuhan Lee ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Nanoparticles ◽  
Low Density ◽  
Solid Lipid

scholarly journals Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver

2021 ◽  
Vol 7 (9) ◽  
pp. eabf4398
Author(s):  
M. Kim ◽  
M. Jeong ◽  
S. Hur ◽  
Y. Cho ◽  
J. Park ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Targeted Delivery ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Nanoparticles ◽  
Liver Sinusoidal Endothelial Cells ◽  
Main Challenge ◽  
Cell Type Specific ◽  
Selective Delivery

Ionizable lipid nanoparticles (LNPs) have been widely used for in vivo delivery of RNA therapeutics into the liver. However, a main challenge remains to develop LNP formulations for selective delivery of RNA into certain types of liver cells, such as hepatocytes and liver sinusoidal endothelial cells (LSECs). Here, we report the engineered LNPs for the targeted delivery of RNA into hepatocytes and LSECs. The effects of particle size and polyethylene glycol–lipid content in the LNPs were evaluated for the hepatocyte-specific delivery of mRNA by ApoE-mediated cellular uptake through low-density lipoprotein receptors. Targeted delivery of RNA to LSECs was further investigated using active ligands. Incorporation of mannose allowed the selective delivery of RNA to LSECs, while minimizing the unwanted cellular uptake by hepatocytes. These results demonstrate that engineered LNPs have great potential for the cell type–specific delivery of RNA into the liver and other tissues.

Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells

2014 ◽  
Vol 114 ◽  
pp. 407-415 ◽  
Author(s):  
Tuan Hiep Tran ◽  
Ju Yeon Choi ◽  
Thiruganesh Ramasamy ◽  
Duy Hieu Truong ◽  
Chien Ngoc Nguyen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Targeted delivery of curcumin using MgONPs and solid lipid nanoparticles: Attenuates aluminum.induced neurotoxicity in albino rats

2020 ◽  
Vol 12 (4) ◽  
pp. 380
Author(s):  
JohnSushma Nannepaga ◽  
Swathi Ganna ◽  
RajasekharaReddy Gutturu ◽  
Rajesh Megala ◽  
Rasajna Nadella ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Albino Rats ◽  
Solid Lipid

scholarly journals Targeted delivery of hyaluronic acid-coated solid lipid nanoparticles for rheumatoid arthritis therapy

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 716-722 ◽  
Author(s):  
Meiling Zhou ◽  
Jierong Hou ◽  
Zhirong Zhong ◽  
Na Hao ◽  
Yan Lin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid
Sign in / Sign up

Export Citation Format

Share Document