scholarly journals Are polyunsaturated fatty acid metabolites, the protective effect of 4-hydroxytyrosol on human red blood cell membranes and oxidative damage (4-hydroxyalkenals) compatible in hypertriglyceridemic patients?

2017 ◽  
Vol 13 (51) ◽  
pp. 561 ◽  
Author(s):  
Giuseppe Gallo ◽  
Rosalinda Bruno ◽  
Adele Taranto ◽  
Guglielmo Martino
Keyword(s):  
Fatty Acid ◽  
Blood Cell ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Polyunsaturated Fatty Acid ◽  
Red Blood Cell ◽  
Cell Membranes ◽  
Acid Metabolites ◽  
Red Blood Cell Membranes ◽  
Fatty Acid Metabolites

Disappearance of Oxidative Damage to Red Blood Cell Membranes in Uremic Patients Following Renal Transplant

1989 ◽  
Vol 35 (3) ◽  
pp. 533-534 ◽  
Author(s):  
MASSIMO TACCONE-GALLUCCI ◽  
RICCARDO LUBRANO ◽  
ANNA BELLI ◽  
CARLO MELONI ◽  
MASSIMO MOROSETTI ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Blood Cell ◽  
Oxidative Damage ◽  
Red Blood Cell ◽  
Cell Membranes ◽  
Uremic Patients ◽  
Red Blood Cell Membranes

scholarly journals Abnormal Fatty Acid Turnover in the Phospholipids of the Red Blood Cell Membranes of Cystic Fibrosis Patients (in Vitro Study)

1984 ◽  
Vol 18 (8) ◽  
pp. 704-709 ◽  
Author(s):  
Vera Rogiers ◽  
Isidoor Dab ◽  
Yvette Michotte ◽  
Antoine Vercruysse ◽  
Robert Crokaert ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Membranes ◽  
In Vitro Study ◽  
Vitro Study ◽  
Fatty Acid Turnover ◽  
Red Blood Cell Membranes

scholarly journals A Rapid and Simple Method for Fatty Acid Profiling and Determination of ω-3 Index in Red Blood Cells

2017 ◽  
Vol 11 (1) ◽  
pp. 17-26
Author(s):  
Olufunmilola Akinyemi ◽  
Geza Bruckner ◽  
John Johnson ◽  
Terry A. Lennie ◽  
David Hildebrand
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Sodium Methoxide ◽  
Cell Membranes ◽  
Simple Method ◽  
Fatty Acid Profiling ◽  
Red Blood Cell Membranes

Fatty acid profiling has become a very useful and effective tool in the diagnosis, prevention and treatment of several diseases with cardiovascular disease being particularly important. In order to arrive at accurate conclusions that would help promote the health of individuals plagued by such diseases, not only excellent laboratory methods are required, but also very important monitoring responses to treatment. Improvements in methods of fatty acid profiling in biological systems regarding safety of extraction, precision and time for analysis are valuable. The ω-3 index (a measure of the amount of eicosapentaenoic acid, EPA, and docosahexaenoic acid, DHA, in Red Blood Cell membranes expressed as the percent of total fatty acids) is of growing interest because it has been reported to provide prognostic information regarding the risk for heart diseases. Sodium methoxide has been widely used for the determination of ω -3 fatty acids in food samples. This study demonstrates that sodium methoxide can be used effectively in RBC fatty acid profiling and determination of the ω-3 index. Briefly, the fatty acid profiles and ω-3 index of red blood cell samples were analyzed and results compared using three different methods: a two- step extraction and methylation method described by Hara and Radin, a single step extraction and methylation method described by Harris et al. and the sodium methoxide method. Our results revealed that there were no statistically significant differences (p<0.05) between the three methods for the representative fatty acids, [16:0 (p = 0.10), 18:0 (p=0.40), 18:1(ω9) (p = 0.29), 18:2(ω6) (p = 0.95), 18:3(ω3) (p = 0.50), 20:5(ω3) (p=0.56), 22:6(ω3) (p = 0.06)] and ω-3 index (p = 0.11) except for 20:4(ω6), (P = 0.02). In conclusion, we show that sodium methoxide can be used effectively in a one-step extraction and methylation procedure for high throughput analysis of fatty acids in red blood cell membranes. It is rapid (10 minute extraction and methylation), simple, safer than and as accurate as other commonly reported methods.

Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients

1998 ◽  
Vol 43 (5) ◽  
pp. 315-319 ◽  
Author(s):  
Malcolm Peet ◽  
Brendan Murphy ◽  
Janet Shay ◽  
David Horrobin
Keyword(s):  
Fatty Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Membranes ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Red Blood Cell Membranes ◽  
Depressive Patients
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