scholarly journals Demineralized dentin matrix scaffolds for alveolar bone engineering

2017 ◽  
Vol 17 (2) ◽  
pp. 120 ◽  
Author(s):  
In-Woong Um ◽  
Young-Kyun Kim ◽  
Masaharu Mitsugi
Keyword(s):  
Alveolar Bone ◽  
Bone Engineering ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

Full Regeneration of Maxillary Alveolar Bone Using Autogenous Partially Demineralized Dentin Matrix and Particulate Cancellous Bone and Marrow for Implant-Supported Full Arch Rehabilitation

2020 ◽  
Vol 46 (2) ◽  
pp. 122-127 ◽  
Author(s):  
Mayumi Umebayashi ◽  
Seigo Ohba ◽  
Tadafumi Kurogi ◽  
Sawako Noda ◽  
Izumi Asahina
Keyword(s):  
Cancellous Bone ◽  
Alveolar Bone ◽  
Graft Material ◽  
Oral Rehabilitation ◽  
Wide Range ◽  
Old Japanese ◽  
Sinus Floor Augmentation ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

Autogenous partially demineralized dentin matrix (APDDM) has been reportedly used as a superior bone graft material. A 52-year-old Japanese man who exhibited severe periodontitis was referred for oral rehabilitation. He underwent wide-range anterior maxillary alveolar bone and bilateral sinus floor augmentation by grafting of a mixture of APDDM and particulate cancellous bone and marrow (PCBM); subsequently, he underwent implant-supported full arch rehabilitation. He has been followed up for 4 years after placement of the final restoration without any complications, and his physiological bone volume has been maintained. APDDM constitutes an alternative treatment that may increase the volume of graft material and might prevent rapid resorption of PCBM, because APDDM served as a scaffold for osteoblasts from PCBM. When possible, it may be useful to apply APDDM as a graft material with PCBM for large-volume alveolar bone regeneration.

scholarly journals Retrospective Clinical Study of Allogenic Demineralized Dentin Matrix for Alveolar Bone Repair

2017 ◽  
Vol 26 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Young-Kyun Kim ◽  
Kang-Mi Bang ◽  
Masaru Murata ◽  
Masaharu Mitsugi ◽  
In-Woong Um
Keyword(s):  
Clinical Study ◽  
Bone Repair ◽  
Alveolar Bone ◽  
Retrospective Clinical Study ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

Tooth Derived Bone Graft Material

2016 ◽  
Vol 7 (1) ◽  
pp. 32-35 ◽  
Author(s):  
Kalyana Chakravarthy Pentapati ◽  
Komal Smriti ◽  
Chayanika Bhattacharjya ◽  
Srikanth Gadicherla ◽  
Abhay Taranath Kamath
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Grafting ◽  
Alveolar Bone ◽  
Autogenous Bone ◽  
Graft Material ◽  
Bone Graft Material ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

ABSTRACT Alveolar bone deficiency is a major postoperative complication in the treatment of traumatic injuries, periodontal diseases and likewise. Hence, alveolar bone repair remains a major hurdle in tissue engineering. Autogenous bone can be wellthought- of as benchmark for bone grafting sans its limitations and complications. In order to overcome these limitations, there is an increased demand of bone graft materials that led to numerous studies on different techniques and materials for bone regeneration over the years. Dentin and bone having same biochemical similarities led to the idea of using it as a bone regenerative material. Demineralized dentin matrix (DDM), an organic material obtained from dentin has been shown to possess osteogenic capacity. Demineralized dentin matrix may prosper in future endodontic world as an apexification material and as a permanent root canal filling material as well. Quick in bone forming as compared to conventional bone graft, this material is a boon to the dental world in this era. This manuscript reviews various studies on different types of DDM as a bone grafting material, and also summarizes the suggested pathway of bone regeneration. How to cite this article Bhattacharjya C, Gadicherla S, Kamath AT, Smriti K, Pentapati KC. Tooth Derived Bone Graft Material. World J Dent 2016;7(1):32-35.

scholarly journals Dentin-Derived-Barrier Membrane in Guided Bone Regeneration: A Case Report

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2166
Author(s):  
Jeong-Kui Ku ◽  
In-Woong Um ◽  
Mi-Kyoung Jun ◽  
Il-hyung Kim
Keyword(s):  
Case Report ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Successful Outcome ◽  
Collagen Membrane ◽  
Type I ◽  
Barrier Membrane ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

An autogenous, demineralized, dentin matrix is a well-known osteo-inductive bone substitute that is mostly composed of type I collagen and is widely used in implant dentistry. This single case report describes a successful outcome in guided bone regeneration and dental implantation with a novel human-derived collagen membrane. The authors fabricated a dentin-derived-barrier membrane from a block-type autogenous demineralized dentin matrix to overcome the mechanical instability of the collagen membrane. The dentin-derived-barrier acted as an osteo-inductive collagen membrane with mechanical and clot stabilities, and it replaced the osteo-genetic function of the periosteum. Further research involving large numbers of patients should be conducted to evaluate bone forming capacity in comparison with other collagen membranes.

scholarly journals Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft

2018 ◽  
Vol 8 (8) ◽  
pp. 1288 ◽  
Author(s):  
Gyu-Un Jung ◽  
Tae-Hyun Jeon ◽  
Mong-Hun Kang ◽  
In-Woong Um ◽  
In-Seok Song ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 2 ◽  
Ridge Preservation ◽  
Tissue Volume ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Recombinant Human Bone ◽  
Demineralized Dentin

The aim of this study was to evaluate the clinical, volumetric, radiographic, and histologic aspects of autogenous demineralized dentin matrix (DDM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) used for ridge preservation, compared to those of deproteinized bovine bone with collagen (DBBC). Following atraumatic extraction, the socket was filled with DBBC, DDM, or rhBMP-2/DDM. Scanned images of dental casts and cone beam computed tomographs (CBCT) were superimposed for the calculation of soft and hard tissue volume alteration. Preoperative and postoperative measurements of the height and width of the alveolar ridge were compared using CBCT images. After 4 months, bone specimens were harvested for histomorphometric assessment. Loss of hard and soft tissue volume occurred at 4 months after extraction and ridge preservation in all groups. No volumetric differences were detected among the three groups before and 4 months after ridge preservation. The reduction in the horizontal width at 5 mm was higher in the DBBC compared to the DDM. Histologically, approximately 40% newly formed bone was founded in rhBMP-2/DDM group. The autogenous dentin matrix used to fill the socket was as beneficial for ridge preservation as conventional xenografts. The combination of rhBMP-2 with dentin matrix also demonstrated appreciable volumetric stability and higher new bone formation compared to DDM alone and DBBC.

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