Sex differences and the modulating effects of gonad intactness on behavioral conformity in a mouse model

2019 ◽  
Vol 62 (6) ◽  
pp. 245
Author(s):  
ChianfangG Cherng ◽  
Lung Yu
Keyword(s):  
Sex Differences ◽  
Mouse Model

Sex differences in response to a high fat diet in an Alzheimer’s Disease mouse model

2018 ◽  
Author(s):  
Alejandra Freire Fernández-Regatillo ◽  
María L. de Ceballos ◽  
Jesús Argente ◽  
Sonia Díaz Pacheco ◽  
Clara González Martínez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sex Differences ◽  
Mouse Model ◽  
High Fat Diet ◽  
High Fat

scholarly journals Sex differences in the temporal development of pronociceptive immune responses in the tibia fracture mouse model

Pain ◽  
2019 ◽  
Vol 160 (9) ◽  
pp. 2013-2027 ◽  
Author(s):  
Tian-Zhi Guo ◽  
Xiaoyou Shi ◽  
Wen-Wu Li ◽  
Tzuping Wei ◽  
J. David Clark ◽  
...  
Keyword(s):  
Sex Differences ◽  
Mouse Model ◽  
Immune Responses ◽  
Tibia Fracture ◽  
Temporal Development

scholarly journals 21: Sex differences in offspring memory and anxiety in a mouse model of maternal diet-induced obesity

2017 ◽  
Vol 216 (1) ◽  
pp. S15-S16 ◽  
Author(s):  
Andrea G. Edlow ◽  
Larissa H. Mattei ◽  
Ingy O. Khattaby ◽  
Charlotte A. Williamson ◽  
Sanaya Daruvala ◽  
...  
Keyword(s):  
Sex Differences ◽  
Mouse Model ◽  
Maternal Diet ◽  
Diet Induced Obesity

scholarly journals Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease

2018 ◽  
Vol 10 ◽  
Author(s):  
Alice E. Kane ◽  
Sooyoun Shin ◽  
Aimee A. Wong ◽  
Emre Fertan ◽  
Natalia S. Faustova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sex Differences ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Ad Mouse Model

scholarly journals A Behavioral Evaluation of Sex Differences in a Mouse Model of Severe Neuronal Migration Disorder

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73144 ◽  
Author(s):  
Dongnhu T. Truong ◽  
Ashley Bonet ◽  
Amanda R. Rendall ◽  
Glenn D. Rosen ◽  
Roslyn H. Fitch
Keyword(s):  
Sex Differences ◽  
Mouse Model ◽  
Neuronal Migration ◽  
Neuronal Migration Disorder ◽  
Migration Disorder

scholarly journals Sex differences in lung miRNA‐712 expression and inflammatory cytokines in a mouse model of asthma and air pollution exposure

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Ashley Morgon Weaver ◽  
Nathalie Fuentez ◽  
Rachel Steckbeck ◽  
Lidys Riviera ◽  
Marvin Nicoleau ◽  
...  
Keyword(s):  
Air Pollution ◽  
Sex Differences ◽  
Mouse Model ◽  
Inflammatory Cytokines ◽  
Air Pollution Exposure ◽  
Pollution Exposure

scholarly journals Sex differences in chronic social stress models in mice

2019 ◽  
Author(s):  
Orit Furman ◽  
Michael Tsoory ◽  
Alon Chen
Keyword(s):  
Sex Differences ◽  
Animal Models ◽  
Mouse Model ◽  
Treatment Response ◽  
Chronic Stress ◽  
Social Stress ◽  
Molecular Mechanisms ◽  
Body Weight Loss ◽  
Chronic Social Stress

AbstractChronic stress creates an allostatic overload that may lead to mood disorders such as anxiety and depression. Modern causes of chronic stress in humans are mostly social in nature, relating to work and relationship stress. Research into neural and molecular mechanisms of vulnerability and resilience following chronic social stress (CSS) is ongoing and uses animal models to discover efficient prevention strategies and treatments. To date, most CSS studies have neglected the female sex and used male-focused aggression-based animal models such as chronic social defeat stress (CSDS). Accumulating evidence on sex differences suggests differences in the stress response, the prevalence of stress-related illness and the treatment response, indicating that researchers should expand CSS investigation to include female-focused protocols alongside the popular CSDS protocols. Here, we describe a novel female mouse model of CSS and a parallel modified male mouse model of CSDS in C57BL/6 mice. These new models enable the investigation of vulnerability, coping and downstream effectors mediating long-term consequences of CSS in both sexes. Our data demonstrate sex differences during CSS and for many weeks following CSS. Female mice are more prone to body weight loss during CSS and hyperactive anxious behavior following CSS. Both sexes show disturbances in social interaction, but only stressed male mice show long-term changes in neuroendocrine function and memory performance after fear conditioning. We discuss future avenues of research using these models to investigate mechanisms pertaining to sensitivity to CSS as well as treatment response profiles, in a sex-suitable manner.

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