scholarly journals (376) Sex differences in an early life stress mouse model of comorbid mood disorder and urogenital pain

2016 ◽  
Vol 17 (4) ◽  
pp. S69
Author(s):  
I. Fuentes ◽  
O. Eller ◽  
A. Pierce ◽  
J. Christianson
Keyword(s):  
Sex Differences ◽  
Mouse Model ◽  
Mood Disorder ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Urogenital Pain

scholarly journals Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model

2018 ◽  
Vol 44 (4) ◽  
pp. 711-720 ◽  
Author(s):  
Haley L. Goodwill ◽  
Gabriela Manzano-Nieves ◽  
Meghan Gallo ◽  
Hye-In Lee ◽  
Esther Oyerinde ◽  
...  
Keyword(s):  
Sex Differences ◽  
Mouse Model ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress

P.207 Sex differences in cocaine consumption vulnerability induced by early-life stress in mice

2021 ◽  
Vol 44 ◽  
pp. S20-S21
Author(s):  
A. Castro-Zavala ◽  
A. Martín-Sánchez ◽  
L. Montalvo-Martínez ◽  
A. Camacho-Morales ◽  
O. Valverde
Keyword(s):  
Sex Differences ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress

scholarly journals A Novel Mouse Model for Acute and Long-Lasting Consequences of Early Life Stress

Endocrinology ◽  
2008 ◽  
Vol 149 (10) ◽  
pp. 4892-4900 ◽  
Author(s):  
Courtney J. Rice ◽  
Curt A. Sandman ◽  
Mohammed R. Lenjavi ◽  
Tallie Z. Baram
Keyword(s):  
Mouse Model ◽  
Paraventricular Nucleus ◽  
Life Stress ◽  
Early Life ◽  
Molecular Mechanisms ◽  
Early Life Stress ◽  
Plasma Corticosterone ◽  
Mrna Levels ◽  
Dependent Manner ◽  
Basal Plasma

Chronic early-life stress (ES) exerts profound acute and long-lasting effects on the hypothalamic-pituitary-adrenal system, with relevance to cognitive function and affective disorders. Our ability to determine the molecular mechanisms underlying these effects should benefit greatly from appropriate mouse models because these would enable use of powerful transgenic methods. Therefore, we have characterized a mouse model of chronic ES, which was provoked in mouse pups by abnormal, fragmented interactions with the dam. Dam-pup interaction was disrupted by limiting the nesting and bedding material in the cages, a manipulation that affected this parameter in a dose-dependent manner. At the end of their week-long rearing in the limited-nesting cages, mouse pups were stressed, as apparent from elevated basal plasma corticosterone levels. In addition, steady-state mRNA levels of CRH in the hypothalamic paraventricular nucleus of ES-experiencing pups were reduced, without significant change in mRNA levels of arginine vasopressin. Rearing mouse pups in this stress-provoking cage environment resulted in enduring effects: basal plasma corticosterone levels were still increased, and CRH mRNA levels in paraventricular nucleus remained reduced in adult ES mice, compared with those of controls. In addition, hippocampus-dependent learning and memory functions were impaired in 4- to 8-month-old ES mice. In summary, this novel, robust model of chronic early life stress in the mouse results in acute and enduring neuroendocrine and cognitive abnormalities. This model should facilitate the examination of the specific genes and molecules involved in the generation of this stress as well as in its consequences.

(267) The Influence of Long-Term Western Diet and Voluntary Exercise in an Early Life Stress Mouse Model of Co-Morbid Disorders

2019 ◽  
Vol 20 (4) ◽  
pp. S41
Author(s):  
O. Eller-Smith ◽  
X. Yang ◽  
E. Morris ◽  
J. Thyfault ◽  
J. Christianson
Keyword(s):  
Mouse Model ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Western Diet ◽  
Voluntary Exercise

scholarly journals Sex-Specific Effects of Early Life Stress on Brain Mitochondrial Function, Monoamine Levels and Neuroinflammation

2020 ◽  
Vol 10 (7) ◽  
pp. 447 ◽  
Author(s):  
Héctor González-Pardo ◽  
Jorge L. Arias ◽  
Eneritz Gómez-Lázaro ◽  
Isabel López Taboada ◽  
Nélida M. Conejo
Keyword(s):  
Sex Differences ◽  
Prefrontal Cortex ◽  
Mitochondrial Function ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Female Rats ◽  
Dopamine Turnover ◽  
Mitochondrial Energy Metabolism ◽  
Brain Mitochondrial Function

Sex differences have been reported in the susceptibility to early life stress and its neurobiological correlates in humans and experimental animals. However, most of the current research with animal models of early stress has been performed mainly in males. In the present study, prolonged maternal separation (MS) paradigm was applied as an animal model to resemble the effects of adverse early experiences in male and female rats. Regional brain mitochondrial function, monoaminergic activity, and neuroinflammation were evaluated as adults. Mitochondrial energy metabolism was greatly decreased in MS females as compared with MS males in the prefrontal cortex, dorsal hippocampus, and the nucleus accumbens shell. In addition, MS males had lower serotonin levels and increased serotonin turnover in the prefrontal cortex and the hippocampus. However, MS females showed increased dopamine turnover in the prefrontal cortex and increased norepinephrine turnover in the striatum, but decreased dopamine turnover in the hippocampus. Sex differences were also found for pro-inflammatory cytokine levels, with increased levels of TNF-α and IL-6 in the prefrontal cortex and hippocampus of MS males, and increased IL-6 levels in the striatum of MS females. These results evidence the complex sex- and brain region-specific long-term consequences of early life stress.

P.579 Sex differences in depressive-like behavior in adult rats subjected to early life stress

2019 ◽  
Vol 29 ◽  
pp. S405
Author(s):  
N. Broshevitskaya ◽  
I. Pavlova ◽  
M. Zaichenko ◽  
V. Gruzdeva ◽  
G. Grigoryan
Keyword(s):  
Sex Differences ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Adult Rats

scholarly journals Maternal Separation Induces Sex-Specific Differences in Sensitivity to Traumatic Stress

2021 ◽  
Vol 15 ◽  
Author(s):  
Dayan Knox ◽  
Stephanie A. Stout-Oswald ◽  
Melissa Tan ◽  
Sophie A. George ◽  
Israel Liberzon
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Animal Models ◽  
Traumatic Stress ◽  
Life Stress ◽  
Early Life ◽  
Maternal Separation ◽  
Early Life Stress ◽  
Female Rats ◽  
Male Rats

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder with a high economic burden. Two risk factors for increasing the chances of developing PTSD are sex (being female) and early life stress. These risk factors suggest that early life stress-induced changes and sex differences in emotional circuits and neuroendocrinological systems lead to susceptibility to traumatic stress. Exploring mechanisms via which stress leads to specific effects can be accomplished in animal models, but reliable animal models that allow for an examination of how early life stress interacts with sex to increase susceptibility to traumatic stress is lacking. To address this, we examined the effects of early life stress [using the maternal separation (MS) model] and late adolescence/early adult traumatic stress [using the single prolonged stress (SPS) model] on startle reactivity, anxiety-like behavior in the open field (OF), and basal corticosterone levels in male and female rats. Female rats exposed to MS and SPS (MS/SPS) showed enhanced startle reactivity relative to MS/control female rats. Enhanced startle reactivity was not observed in MS/SPS male rats. Instead, non-maternally separated male rats that were exposed to SPS showed enhanced startle reactivity relative to controls. Female rats had enhanced locomotor activity in the OF and higher basal corticosterone levels in comparison to males, but measures in the OF and basal corticosterone were not affected by MS or SPS. Overall the results suggest that the combined MS and SPS models can be used to explore how changes in maternal care during infancy lead to sex differences in sensitivity to the effects of traumatic stress as adolescents and adults.

scholarly journals Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer’s disease mouse model

2017 ◽  
Vol 63 ◽  
pp. 160-175 ◽  
Author(s):  
Lianne Hoeijmakers ◽  
Silvie R. Ruigrok ◽  
Anna Amelianchik ◽  
Daniela Ivan ◽  
Anne-Marie van Dam ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Neuroinflammatory Response ◽  
Amyloid Pathology
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