scholarly journals Clinical and radiographic evaluation of citric acid-based nano hydroxyapatite composite graft in the regeneration of intrabony defects - A randomized controlled trial

2017 ◽  
Vol 8 (3) ◽  
pp. 380 ◽  
Author(s):  
ChaurasiaPriya Dayashankar ◽  
PC Deepika ◽  
Basavarajaiah Siddaramaiah
Keyword(s):  
Randomized Controlled Trial ◽  
Citric Acid ◽  
Controlled Trial ◽  
Composite Graft ◽  
Radiographic Evaluation ◽  
Intrabony Defects ◽  
Randomized Controlled ◽  
Hydroxyapatite Composite

scholarly journals Effect of enamel matrix proteins on the treatment of intrabony defects: a split-mouth randomized controlled trial study

2007 ◽  
Vol 21 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Daniela Chambrone ◽  
Ivan Munhoz Pasin ◽  
Marina Clemente Conde ◽  
Claudio Panutti ◽  
Silvia Carneiro ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Matrix Proteins ◽  
Treatment Modalities ◽  
Enamel Matrix ◽  
Intrabony Defects ◽  
Enamel Matrix Proteins ◽  
Pocket Depth ◽  
Randomized Controlled ◽  
Significant Difference

The objective of this split-mouth, double-blind, randomized controlled trial was to compare the clinical effect of treatment of 2- or 3-wall intrabony defects with open flap debridement (OFD) combined or not with enamel matrix proteins (EMP). Thirteen volunteers were selected with one pair of or more intrabony defects and probing pocket depth (PPD) > 5 mm. All individuals received instructions regarding oral hygiene and were submitted to scaling and root planing. Each participant received the two treatment modalities: test sites were treated with OFD and EMP, and control sites received only OFD. After 6 months, a significant reduction was observed in PPD for the EMP group (from 6.42 ± 1.08 mm to 2.67 ± 1.15 mm) and for the OFD group (from 6.08 ± 1.00 mm to 2.00 ± 0.95 mm) (p < 0.0001), but with no significant difference between groups (p = 0.13). A significant gain in relative attachment level (RAL) was observed in both groups (EMP: from 13.42 ± 1.88 mm to 10.75 ± 2.26 mm, p < 0.001; OFD: from 12.42 ± 1.98 mm to 10.58 ± 2.23 mm, p = 0.013), but with no significant difference between groups (p = 0.85). Gingival recession (GR) was higher in the EMP group (from 1.08 ± 1.50 mm to 2.33 ± 1.43 mm; p = 0.0009) than in the OFD group (from 0.66 ± 1.15 mm to 1.16 ± 1.33 mm; p = 0.16), but this difference was not significant (p = 0.06). In conclusion, the results showed that OFD combined with EMP was not able to improve treatment of intrabony defects compared to OFD alone.

Randomized controlled trial of the application of topical b-FGF-impregnated gelatin microspheres to improve tissue survival in subzone II fingertip amputations

2011 ◽  
Vol 36 (6) ◽  
pp. 455-460 ◽  
Author(s):  
Hirohisa Kusuhara ◽  
Yoshihito Itani ◽  
Noritaka Isogai ◽  
Yasuhiko Tabata
Keyword(s):  
Randomized Controlled Trial ◽  
Standard Treatment ◽  
Controlled Trial ◽  
Statistical Significance ◽  
Clinical Decision ◽  
Composite Graft ◽  
Gelatin Microspheres ◽  
Modest Improvement ◽  
Randomized Controlled ◽  
Tissue Surfaces

We undertook a randomized controlled trial of subzone II fingertip amputations, comparing standard treatment with topical application of gelatin microspheres prepared with basic fibroblast growth factor (b-FGF) to provide a slow, sustained release of b-FGF with microsphere degradation. Forty-eight digits from 42 patients were randomized into the two study arms. The microspheres were applied as a paste on exposed tissue surfaces, whereas standard treatment was without any topical treatment. Patients were treated either with microsurgical revascularization or by simple composite graft, based on the surgeon’s clinical decision. Tissue survival of the replanted fingertips was measured by a blinded evaluator 3 weeks postoperatively. A modest improvement in survival was seen with b-FGF-microsphere application for both revascularized and composite grafted fingertips, though this did not achieve statistical significance. Whether the slow release of b-FGF through a bioresorbable carrier gives any improvement in outcome in patients with subzone II fingertip amputations is unproven.

Evaluation of Immediate Implants Augmented with Autogenous Bone/Melatonin Composite Graft in the Esthetic Zone: A Randomized Controlled Trial

2017 ◽  
Vol 28 (2) ◽  
pp. e637-e642
Author(s):  
Hala H. A. Hazzaa ◽  
Naglaa Sh. El-Kilani ◽  
Shadia Abd-Elhameed Elsayed ◽  
Phoebe M. Abd El Massieh
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Composite Graft ◽  
Autogenous Bone ◽  
Randomized Controlled ◽  
Immediate Implants
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