scholarly journals Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial

2017 ◽  
Vol 11 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Santosh S. Martande ◽  
Minal Kumari ◽  
A. R. Pradeep ◽  
Sonender Pal Singh ◽  
Deepak Kumar Suke
Keyword(s):  
Randomized Controlled Trial ◽  
Chronic Periodontitis ◽  
Comparative Evaluation ◽  
Controlled Trial ◽  
Intrabony Defects ◽  
Randomized Controlled

scholarly journals Effect of enamel matrix proteins on the treatment of intrabony defects: a split-mouth randomized controlled trial study

2007 ◽  
Vol 21 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Daniela Chambrone ◽  
Ivan Munhoz Pasin ◽  
Marina Clemente Conde ◽  
Claudio Panutti ◽  
Silvia Carneiro ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Matrix Proteins ◽  
Treatment Modalities ◽  
Enamel Matrix ◽  
Intrabony Defects ◽  
Enamel Matrix Proteins ◽  
Pocket Depth ◽  
Randomized Controlled ◽  
Significant Difference

The objective of this split-mouth, double-blind, randomized controlled trial was to compare the clinical effect of treatment of 2- or 3-wall intrabony defects with open flap debridement (OFD) combined or not with enamel matrix proteins (EMP). Thirteen volunteers were selected with one pair of or more intrabony defects and probing pocket depth (PPD) > 5 mm. All individuals received instructions regarding oral hygiene and were submitted to scaling and root planing. Each participant received the two treatment modalities: test sites were treated with OFD and EMP, and control sites received only OFD. After 6 months, a significant reduction was observed in PPD for the EMP group (from 6.42 ± 1.08 mm to 2.67 ± 1.15 mm) and for the OFD group (from 6.08 ± 1.00 mm to 2.00 ± 0.95 mm) (p < 0.0001), but with no significant difference between groups (p = 0.13). A significant gain in relative attachment level (RAL) was observed in both groups (EMP: from 13.42 ± 1.88 mm to 10.75 ± 2.26 mm, p < 0.001; OFD: from 12.42 ± 1.98 mm to 10.58 ± 2.23 mm, p = 0.013), but with no significant difference between groups (p = 0.85). Gingival recession (GR) was higher in the EMP group (from 1.08 ± 1.50 mm to 2.33 ± 1.43 mm; p = 0.0009) than in the OFD group (from 0.66 ± 1.15 mm to 1.16 ± 1.33 mm; p = 0.16), but this difference was not significant (p = 0.06). In conclusion, the results showed that OFD combined with EMP was not able to improve treatment of intrabony defects compared to OFD alone.

Benefits of non-surgical periodontal treatment in patients with type 2 diabetes mellitus and chronic periodontitis: A randomized controlled trial

2018 ◽  
Vol 45 (3) ◽  
pp. 345-353 ◽  
Author(s):  
Elisabet Mauri-Obradors ◽  
Alexandra Merlos ◽  
Albert Estrugo-Devesa ◽  
Enric Jané-Salas ◽  
José López-López ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Randomized Controlled Trial ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Periodontitis ◽  
Controlled Trial ◽  
Periodontal Treatment ◽  
Randomized Controlled

A comparative evaluation of two investigational meningococcal ABCWY vaccine formulations: Results of a phase 2 randomized, controlled trial

Vaccine ◽  
2015 ◽  
Vol 33 (21) ◽  
pp. 2500-2510 ◽  
Author(s):  
Stan L. Block ◽  
Leszek Szenborn ◽  
Wendy Daly ◽  
Teresa Jackowska ◽  
Diego D’Agostino ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Comparative Evaluation ◽  
Controlled Trial ◽  
Phase 2 ◽  
Randomized Controlled
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