scholarly journals Commentary on “CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice”

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
BrendanJ Houston
Keyword(s):  
Genome Editing ◽  
Male Fertility

scholarly journals Impact of Spontaneous Haploid Genome Doubling in Maize Breeding

Plants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 369 ◽  
Author(s):  
Nicholas A. Boerman ◽  
Ursula K. Frei ◽  
Thomas Lübberstedt
Keyword(s):  
Genome Editing ◽  
Male Fertility ◽  
Gene Pyramiding ◽  
Haploid Genome ◽  
Systematic Design ◽  
Maize Breeding ◽  
Genome Doubling ◽  
New Methodologies ◽  
Marker Assisted Backcrossing ◽  
The Impact

Doubled haploid (DH) technology has changed the maize-breeding landscape in recent years. Traditionally, DH production requires the use of chemical doubling agents to induce haploid genome doubling and, subsequently, male fertility. These chemicals can be harmful to humans and the plants themselves, and typically result in a doubling rate of 10%–30%. Spontaneous genome doubling and male fertility of maize haploids, without using chemical doubling agents, have been observed to a limited extent, for nearly 70 years. Rates of spontaneous haploid genome doubling (SHGD) have ranged from less than 5% to greater than 50%. Recently, there has been increased interest to forgo chemical treatment and instead utilize this natural method of doubling. Genetic-mapping studies comprising worldwide germplasm have been conducted. Of particular interest has been the detection of large-effect quantitative trait loci (QTL) affecting SHGD. Having a single large-effect QTL with an additive nature provides flexibility for the method of introgression, such as marker-assisted backcrossing, marker-assisted gene pyramiding, and systematic design. Moreover, it allows implementation of new methodologies, such as haploid-inducer mediated genome editing (HI-edit) and promotion of alleles by genome editing. We believe the use of SHGD can further enhance the impact of DH technology in maize.

scholarly journals Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR/Cas9

2017 ◽  
Vol 17 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Ferheen Abbasi ◽  
Haruhiko Miyata ◽  
Masahito Ikawa
Keyword(s):  
Genome Editing ◽  
Male Fertility ◽  
Fertility Factor

CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Haruhiko Miyata ◽  
Yuki Oyama ◽  
Keisuke Shimada ◽  
Yoshitaka Fujihara ◽  
Keizo Tokuhiro ◽  
...  
Keyword(s):  
Genome Editing ◽  
Male Fertility

Genome editing: Wollen wir das wirklich?

2017 ◽  
Vol 6 (3) ◽  
pp. 162-162
Author(s):  
Liane Kaufmann ◽  
Michael von Aster
Keyword(s):  
Genome Editing

Genome editing (CRISPR-Cas9) to identify and characterise functional variants determining metformin response

2018 ◽  
Author(s):  
M Keller ◽  
J Dalla-Riva ◽  
A Kurbasic ◽  
M Al-Majdoub ◽  
P Spegel ◽  
...  
Keyword(s):  
Genome Editing ◽  
Functional Variants

Effect of new dietary supplement on sperm quality

2012 ◽  
Vol 153 (45) ◽  
pp. 1787-1792 ◽  
Author(s):  
Mária Horváth ◽  
Endre Czeizel
Keyword(s):  
Adverse Effect ◽  
Clinical Trial ◽  
Dietary Supplement ◽  
Male Fertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Before And After ◽  
The Usa ◽  
New Treatments

Introduction: There is a decline in male fertility thus new treatments are needed. Aims: To test the efficacy of a new dietary supplement developed in the USA and registered as a curing drug in Hungary (OGYI). Methods: In a clinical trial 100 men with low sperm quality (spermium count 5–20 M/ml, good motility 10–40%, and adverse shape 30–50%) were examined. Results: Sperm parameters were measured before and after a 3-month treatment and after another 3-month without treatment. This dietary supplement statistically and clinically significantly improved sperm count and motility. In 74 cases this dietary supplement demonstrated a beneficial effect on sperm quality (more than 10% increase in sperm count, or quality of motility, or shape); in 16 cases the improvement exceeded 30%. No adverse effect could be accounted for this treatment. Conclusions: This new dietary supplement may contribute to the treatment of male infertility. Orv. Hetil., 2012, 153, 1787–1792.

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