scholarly journals Mesenchymal stem cell treatment for peripheral nerve injury: a narrative review

2021 ◽  
Vol 16 (11) ◽  
pp. 2170
Author(s):  
Yan-Bo Cheng ◽  
Chao Ren ◽  
De-Qin Geng ◽  
Rui-Cheng Zhang ◽  
Wen-Qi Du ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Narrative Review ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

scholarly journals Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote the Proliferation of Schwann Cells by Regulating the PI3K/AKT Signaling Pathway via Transferring miR-21

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yongbin Ma ◽  
Dan Zhou ◽  
Huanyan Zhang ◽  
Liming Tang ◽  
Fen Qian ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Nerve Injury ◽  
Umbilical Cord ◽  
Peripheral Nerve Injury ◽  
Akt Signaling ◽  
Human Umbilical Cord ◽  
Akt Signaling Pathway

As an alternative mesenchymal stem cell- (MSC-) based therapy, MSC-derived extracellular vesicles (EVs) have shown promise in the field of regenerative medicine. We previously found that human umbilical cord mesenchymal stem cell-derived EVs (hUCMSC-EVs) improved functional recovery and nerve regeneration in a rat model of sciatic nerve transection. However, the underlying mechanisms are poorly understood. Here, we demonstrated for the first time that hUCMSC-EVs promoted the proliferation of Schwann cells by activating the PI3K/AKT signaling pathway. Furthermore, we showed that hUCMSC-EVs mediated Schwann cell proliferation via transfer of miR-21. Our findings highlight a novel mechanism of hUCMSC-EVs in treating peripheral nerve injury and suggest that hUCMSC-EVs may be an attractive option for clinical application in the treatment of peripheral nerve injury.

scholarly journals FP456CD362+ MESENCHYMAL STEM CELL TREATMENT OF KIDNEY DISEASE IN TYPE 2 DIABETIC LEPR DB/DB MICE

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii223-iii224 ◽  
Author(s):  
Satish Kumar Devarapu ◽  
Xie Junhui ◽  
Murthy Darisipudi ◽  
Anais Rocanin Arjo ◽  
Hans Joachim Anders
Keyword(s):  
Stem Cell ◽  
Kidney Disease ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment ◽  
Type 2 Diabetic

scholarly journals Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease

Medicine ◽  
2018 ◽  
Vol 97 (16) ◽  
pp. e0515 ◽  
Author(s):  
Yanhong Li ◽  
Zhongming Wang ◽  
Yi Zhao ◽  
Yubin Luo ◽  
Wangdong Xu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Behçet Disease ◽  
Leg Ulcers ◽  
Behcet Disease ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

Topically applied adipose-derived mesenchymal stem cell treatment in experimental focal cerebral ischemia

2020 ◽  
Vol 71 ◽  
pp. 226-233
Author(s):  
Ping Kuen Lam ◽  
Kevin Ka Wang Wang ◽  
Don Wai Ching Chin ◽  
Cindy See Wai Tong ◽  
Yixiang Wang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cerebral Ischemia ◽  
Mesenchymal Stem Cell ◽  
Focal Cerebral Ischemia ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

scholarly journals Global Hypoxia-Ischemia Induced Inflammation and Structural Changes in the Preterm Ovine Gut Which Were Not Ameliorated by Mesenchymal Stem Cell Treatment

2016 ◽  
Vol 22 (1) ◽  
pp. 244-257 ◽  
Author(s):  
Maria Nikiforou ◽  
Carolin Willburger ◽  
Anja E de Jong ◽  
Nico Kloosterboer ◽  
Reint K Jellema ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Structural Changes ◽  
Hypoxia Ischemia ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

Effect of osteopontin in regulating bone marrow mesenchymal stem cell treatment of skin wounds in diabetic mice

2014 ◽  
Vol 30 (6) ◽  
pp. 457-466 ◽  
Author(s):  
Hao Meng ◽  
Zhenxiang Wang ◽  
Wenping Wang ◽  
Wei Li ◽  
Qinan Wu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Skin Wounds ◽  
Diabetic Mice ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment
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