Effect of osteopontin in regulating bone marrow mesenchymal stem cell treatment of skin wounds in diabetic mice

2014 ◽  
Vol 30 (6) ◽  
pp. 457-466 ◽  
Author(s):  
Hao Meng ◽  
Zhenxiang Wang ◽  
Wenping Wang ◽  
Wei Li ◽  
Qinan Wu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Skin Wounds ◽  
Diabetic Mice ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

W1088 Autologous Bone Marrow Derived Mesenchymal Stem Cell Treatment in Patients Refractory Crohn's Disease Patients

2009 ◽  
Vol 136 (5) ◽  
pp. A-651
Author(s):  
Marjolijn Duijvestein ◽  
Marthe H. Verwey ◽  
Herma H. Fidder ◽  
Gijs R. van den Brink ◽  
Helene Roelofs ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mesenchymal Stem Cell ◽  
Autologous Bone Marrow ◽  
Autologous Bone ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

Neuroprotective effect of combined hypoxia-induced VEGF and bone marrow-derived mesenchymal stem cell treatment

2009 ◽  
Vol 26 (3) ◽  
pp. 323-331 ◽  
Author(s):  
Sung Su An ◽  
Hong Lian Jin ◽  
Keung Nyun Kim ◽  
Hyun Ah Kim ◽  
Dong Seok Kim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Neuroprotective Effect ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

scholarly journals Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome

Blood ◽  
2012 ◽  
Vol 120 (15) ◽  
pp. 3142-3151 ◽  
Author(s):  
Junji Xu ◽  
Dandan Wang ◽  
Dayong Liu ◽  
Zhipeng Fan ◽  
Huayong Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stromal Cell ◽  
Sjogren Syndrome ◽  
Stromal Cell Derived Factor ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

Abstract Sjögren syndrome (SS) is a systemic autoimmune disease characterized by dry mouth and eyes, and the cellular and molecular mechanisms for its pathogenesis are complex. Here we reveal, for the first time, that bone marrow mesenchymal stem cells in SS-like NOD/Ltj mice and human patients were defective in immunoregulatory functions. Importantly, treatment with mesenchymal stem cells (MSCs) suppressed autoimmunity and restored salivary gland secretory function in both mouse models and SS patients. MSC treatment directed T cells toward Treg and Th2, while suppressing Th17 and Tfh responses, and alleviated disease symptoms. Infused MSCs migrated toward the inflammatory regions in a stromal cell–derived factor-1–dependent manner, as neutralization of stromal cell–derived factor-1 ligand CXCR4 abolished the effectiveness of bone marrow mesenchymal stem cell treatment. Collectively, our study suggests that immunologic regulatory functions of MSCs play an important role in SS pathogenesis, and allogeneic MSC treatment may provide a novel, effective, and safe therapy for patients with SS. This study was registered at www.clinicaltrials.gov as NCT00953485.

Secretome within the bone marrow microenvironment: A basis for mesenchymal stem cell treatment and role in cancer dormancy

Biochimie ◽  
2018 ◽  
Vol 155 ◽  
pp. 92-103 ◽  
Author(s):  
Hussam S. Eltoukhy ◽  
Garima Sinha ◽  
Caitlyn A. Moore ◽  
Marina Gergues ◽  
Pranela Rameshwar
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Marrow Microenvironment ◽  
Cancer Dormancy ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment
Sign in / Sign up

Export Citation Format

Share Document