scholarly journals Preparation and Evaluation of Mixture of Eudragit and Ethylcellulose Microparticles Loaded with Ranolazine for Controlled Release

2011 ◽  
Vol 3 (3) ◽  
pp. 189-196
Author(s):  
D.V. Gowda ◽  
M.P. Gowrav ◽  
H.V. Gangadharappa ◽  
M.S. Khan
Keyword(s):  
Controlled Release ◽  
Preparation And Evaluation

scholarly journals PREPARATION AND EVALUATION OF CHITOSAN SODIUM ALGINATE CARBAMAZEPINE MICROSPHERES

2017 ◽  
Vol 10 (3) ◽  
pp. 271 ◽  
Author(s):  
Sreeja C Nair ◽  
Karthika Ramesh ◽  
Krishnapriya M ◽  
Asha Paul
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Controlled Release ◽  
Sodium Alginate ◽  
Physical Parameters ◽  
Effective Management ◽  
Release Drug ◽  
Conventional Drug ◽  
Preparation And Evaluation ◽  
Evaluation Parameters

ABSTRACTObjective: The objective behind our study is that a mucoadhesive rectal hydrogel chitosan sodium alginate carbamazepine (CBZ) microspheres forthe purpose of controlled release for the treatment of epilepsy to avoid the possible side effects.Methods: The study was conducted to formulate controlled release chitosan sodium alginate CBZ microspheres with the dispersion of CBZ into thenatural polymers chitosan and sodium alginate forming microspheres conducting along with their evaluation studies.Results: The formulated microspheres were subjected to various evaluation parameters, and all the physical parameters examined are within theacceptable limits. Further, the optimized microsphere formulation (CM5) was characterized. Hence, the developed optimized microsphere formulation(CM5) seems to be a viable substitute to conventional drug delivery system for the effective management of epilepsy.Conclusion: The prepared formulation also provides a desired CBZ loaded sodium alginate microspheres with the controlled release drug delivery.Keywords: Carbamazepine, Sodium alginate microspheres, Particle size.

scholarly journals Preparation and evaluation of a time-controlled release capsule made of ethylcellulose for colon delivery of drugs.

1995 ◽  
Vol 10 (2) ◽  
pp. 121-125
Author(s):  
Kiyoshi Niwa ◽  
Tomohiro Takaya ◽  
Shinichiro Kondo ◽  
Yoko Takeshita ◽  
Kanji Takada
Keyword(s):  
Controlled Release ◽  
Colon Delivery ◽  
Preparation And Evaluation

Preparation and Evaluation of Controlled Release Indomethacin Microspheres

1984 ◽  
Vol 10 (10) ◽  
pp. 1597-1616 ◽  
Author(s):  
Y. Pongpaibul ◽  
J. C. Price ◽  
C. W. Whitworth
Keyword(s):  
Controlled Release ◽  
Preparation And Evaluation

scholarly journals Preparation and evaluation of an ispaghula based directly compressible matrixing agent for controlled release

2008 ◽  
Vol 58 (3) ◽  
pp. 309-316 ◽  
Author(s):  
Anita Lalwani ◽  
Jolly Parikh
Keyword(s):  
Controlled Release ◽  
Hydroxypropyl Methylcellulose ◽  
Hydrogen Phosphate ◽  
Lattice Design ◽  
Phosphate Dihydrate ◽  
Simplex Lattice Design ◽  
Dependent Variables ◽  
Simplex Lattice ◽  
Preparation And Evaluation

Preparation and evaluation of an ispaghula based directly compressible matrixing agent for controlled releaseThe objective of the present investigation was to prepare and evaluate an ispaghula husk based directly compressible (DC) adjuvant that can be used as matrixing agent using an agglomeration technique. Addition of hydroxypropyl methylcellulose was found necessary to improve cohesion. Lactose (X1), calcium hydrogen phosphate dihydrate (X2) and Avicel PH101 (X3), used along with ispaghula in preparation of agglomerates, were selected as three independent variables in a simplex lattice design affecting compressional and dissolution characteristics of the drug from the DC adjuvant. The agglomerates were evaluated for their flow properties. Tablets were prepared using 70% agglomerates and 30% acetaminophen, a poorly compressible drug, and were subjected toin vitrodrug release study. Amounts of the drug released at the end of 60 min (Y60), 300 min (Y300) and 480 min (Y480) were selected as dependent variables in a simplex lattice design. Batch IH05 that contained lactose and calcium hydrogen phosphate dihydrate in a 1:2 ratio could control the release for 12 hours and thus form the basis for twice a-day-dosing.

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