PREPARATION AND EVALUATION OF CONTROLLED-RELEASE SODIUM VALPROATE / VALPROIC ACID (VALDISOVAL) TABLETS

2003 ◽  
Vol 26 (2) ◽  
pp. 179-186
Author(s):  
Sayed Khidr
Keyword(s):  
Valproic Acid ◽  
Controlled Release ◽  
Sodium Valproate ◽  
Preparation And Evaluation

scholarly journals PREPARATION AND EVALUATION OF CHITOSAN SODIUM ALGINATE CARBAMAZEPINE MICROSPHERES

2017 ◽  
Vol 10 (3) ◽  
pp. 271 ◽  
Author(s):  
Sreeja C Nair ◽  
Karthika Ramesh ◽  
Krishnapriya M ◽  
Asha Paul
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Controlled Release ◽  
Sodium Alginate ◽  
Physical Parameters ◽  
Effective Management ◽  
Release Drug ◽  
Conventional Drug ◽  
Preparation And Evaluation ◽  
Evaluation Parameters

ABSTRACTObjective: The objective behind our study is that a mucoadhesive rectal hydrogel chitosan sodium alginate carbamazepine (CBZ) microspheres forthe purpose of controlled release for the treatment of epilepsy to avoid the possible side effects.Methods: The study was conducted to formulate controlled release chitosan sodium alginate CBZ microspheres with the dispersion of CBZ into thenatural polymers chitosan and sodium alginate forming microspheres conducting along with their evaluation studies.Results: The formulated microspheres were subjected to various evaluation parameters, and all the physical parameters examined are within theacceptable limits. Further, the optimized microsphere formulation (CM5) was characterized. Hence, the developed optimized microsphere formulation(CM5) seems to be a viable substitute to conventional drug delivery system for the effective management of epilepsy.Conclusion: The prepared formulation also provides a desired CBZ loaded sodium alginate microspheres with the controlled release drug delivery.Keywords: Carbamazepine, Sodium alginate microspheres, Particle size.

scholarly journals Preparation and evaluation of a time-controlled release capsule made of ethylcellulose for colon delivery of drugs.

1995 ◽  
Vol 10 (2) ◽  
pp. 121-125
Author(s):  
Kiyoshi Niwa ◽  
Tomohiro Takaya ◽  
Shinichiro Kondo ◽  
Yoko Takeshita ◽  
Kanji Takada
Keyword(s):  
Controlled Release ◽  
Colon Delivery ◽  
Preparation And Evaluation

scholarly journals Analytical Method Development for Sodium Valproate through Chemical Derivatization

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Murad Abualhasan ◽  
Nihaya Wasif Odeh ◽  
Ghadeer Naser Younis ◽  
Oyoun Fadel Zeidan
Keyword(s):  
Valproic Acid ◽  
Sodium Valproate ◽  
Analytical Method ◽  
Method Development ◽  
Analytical Procedure ◽  
Phenyl Group ◽  
Chemical Derivatization ◽  
Reverse Phase Hplc ◽  
Reverse Phase ◽  
Low Concentrations

Background. Sodium valproate has anticonvulsant activity and is structurally different to conventional antiepileptic drugs. The problem with valproic acid is the lack of a chromophore, which means that gas chromatography is the sole assay methodology. The introduction of benzoyl and phenyl groups to the molecule is a useful derivatisation, which enables the creation of detectable chromophores for HPLC analysis for pharmaceutical dosages as well as biological systems. Methodology. Sodium valproate was derivatised by the addition of a chromophore to its structure by introducing a methyl benzoyl or a phenyl group. Trichlorophenol and 2-hydroxyacetophenone were used to introduce phenyl and benzoyl groups to valproic acid, respectively. The reaction used was estrification reaction using coupling agents. An analytical method was then developed and validated using reverse-phase HPLC. The method was validated for parameters like linearity, range, accuracy precision, and robustness. Results. The developed method was easy and feasible and can be applied to both routine analysis and bioanalysis. The method was very sensitive and could quantify valproic acid at a very low concentration of 0.75 × 10−5 mg/ml. The developed method was found to be linear (R2 = 0.997), accurate, precise, and robust. Conclusion. The proposed chemical derivatisation and the developed analytical method are novel. The developed analytical procedure is the first of its kind; it is easy and feasible and can be used to quantify and detect sodium valproate at very low concentrations compared to other available methods in the literature.

Preparation and Evaluation of Controlled Release Indomethacin Microspheres

1984 ◽  
Vol 10 (10) ◽  
pp. 1597-1616 ◽  
Author(s):  
Y. Pongpaibul ◽  
J. C. Price ◽  
C. W. Whitworth
Keyword(s):  
Controlled Release ◽  
Preparation And Evaluation
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