scholarly journals Trends in the control of heartwater : tick-borne diseases

2009 ◽  
Vol 76 (1) ◽  
Author(s):  
B.A. Allsopp
Keyword(s):  
New Technologies ◽  
Disease Outbreaks ◽  
Effective Vaccine ◽  
Recombinant Vaccines ◽  
Ehrlichia Ruminantium ◽  
Tick Vector ◽  
The Past ◽  
Tick Borne Disease ◽  
Serious Disease ◽  
Endemic Stability

Heartwater is an economically serious tick-borne disease of ruminants caused by the intracellular bacterium Ehrlichia ruminantium. The disease has traditionally been controlled by four different approaches : controlling the tick vector by dipping, establishing endemic stability, performing immunisation by infection and treatment, and preventing the disease by regular administration of prophylactic antibiotics. The first three of these methods are subject to failure for various epidemiological reasons, and serious disease outbreaks can occur. Prophylaxis is effective, but very expensive, and the logistics are daunting when large herds of animals are involved. The development of a safe, cheap and effective vaccine is the only likely way in which heartwater can be economically controlled, and over the past 15 years three new types of experimental vaccine have been developed: inactivated, attenuated, and recombinant vaccines. These new vaccines have shown varying degrees of promise, but none is as yet sufficiently successful to be marketable. We describe the experimental products, and the various technical and biological difficulties which are being encountered, and report on ways in which new technologies are being used to improve vaccine effectiveness.

scholarly journals Therapeutic Advances in Oncology

2021 ◽  
Vol 22 (4) ◽  
pp. 2008
Author(s):  
Jinsha Liu ◽  
Priyanka Pandya ◽  
Sepideh Afshar
Keyword(s):  
Small Molecules ◽  
New Technologies ◽  
Treatment Options ◽  
Current Treatment ◽  
Bispecific Antibodies ◽  
Gene Therapies ◽  
Therapeutic Modalities ◽  
The Past ◽  
Drug Conjugates ◽  
Novel Targets

Around 77 new oncology drugs were approved by the FDA in the past five years; however, most cancers remain untreated. Small molecules and antibodies are dominant therapeutic modalities in oncology. Antibody-drug conjugates, bispecific antibodies, peptides, cell, and gene-therapies are emerging to address the unmet patient need. Advancement in the discovery and development platforms, identification of novel targets, and emergence of new technologies have greatly expanded the treatment options for patients. Here, we provide an overview of various therapeutic modalities and the current treatment options in oncology, and an in-depth discussion of the therapeutics in the preclinical stage for the treatment of breast cancer, lung cancer, and multiple myeloma.

The Future of the Planetary Trust in a Kaleidoscopic World

2021 ◽  
pp. 1-8
Author(s):  
Edith Brown Weiss
Keyword(s):  
Artificial Intelligence ◽  
Natural Resource ◽  
Human Activities ◽  
New Technologies ◽  
Future Generations ◽  
Nuclear War ◽  
Human Environment ◽  
The Past ◽  
Resource Degradation ◽  
Shared Goal

Today, it is evident that we are part of a planetary trust. Conserving our planet represents a public good, global as well as local. The threats to future generations resulting from human activities make applying the normative framework of a planetary trust even more urgent than in the past decades. Initially, the planetary trust focused primarily on threats to the natural system of our human environment such as pollution and natural resource degradation, and on threats to cultural heritage. Now, we face a higher threat of nuclear war, cyber wars, and threats from gene drivers that can cause inheritable changes to genes, potential threats from other new technologies such as artificial intelligence, and possible pandemics. In this context, it is proposed that in the kaleidoscopic world, we must engage all the actors to cooperate with the shared goal of caring for and maintaining planet Earth in trust for present and future generations.

Experiences of Knowledge Transfer on Industrial Heritage Using Games, Storytelling, and New Technologies

2021 ◽  
Vol 14 (2) ◽  
pp. 1-26
Author(s):  
Gonzalo Andrés López ◽  
David Checa Cruz
Keyword(s):  
New Technologies ◽  
Daily Life ◽  
3D Modelling ◽  
Historical Evolution ◽  
Educational Tool ◽  
Economic Activities ◽  
Industrial Heritage ◽  
Urban Economic ◽  
The Past ◽  
A Value

The industry has a relevant spatial and socioeconomic importance in most of the Spanish cities and nowadays is one of the main urban economic activities. However, in many situations, and despite recent advances in the past two decades, industrial heritage is a value that is still not sufficiently widespread in society. The factories, their activity, and their historical evolution are often disconnected and isolated from the daily life of the cities, being quite an unknown aspect for most of the citizens. This contribution presents the result of various experiences of knowledge transmission on the heritage value of industry, through the use of games and storytelling technique as an educational tool and the combination of different technologies (3D modelling, videomapping, virtual reality) as useful tools to spread the explanation of this phenomenon.

New technologies and new policies: the ICRC's evolving approach to working with separated families

2012 ◽  
Vol 94 (888) ◽  
pp. 1455-1479 ◽  
Author(s):  
Olivier Dubois ◽  
Katharine Marshall ◽  
Siobhan Sparkes McNamara
Keyword(s):  
New Technologies ◽  
Rapid Rise ◽  
Changing Environment ◽  
Humanitarian Action ◽  
The Past ◽  
New Policies ◽  
Humanitarian Work ◽  
Insight Into

AbstractThe field of humanitarian action is far from static, and the ICRC has worked over the years to evolve and respond to changing needs and changing circumstances. The past several decades have seen a proliferation of humanitarian actors, protracted, complex conflicts, and the rapid rise of new technologies that have significantly impacted how humanitarian work is done. The ICRC has been continually challenged to adapt in this changing environment, and its core work of supporting separated families – through restoration of family links and through support to the families of the missing – provides insight into ways that it has met this challenge and areas in which it may still seek to improve.

BIG DATA PROCESSING IN THE DIGITALIZATION OF ENTERPRISE ACTIVITIES

2021 ◽  
Vol 75 (3) ◽  
pp. 76-82
Author(s):  
G.T. Balakayeva ◽  
◽  
D.K. Darkenbayev ◽  
M. Turdaliyev ◽  
◽  
...  
Keyword(s):  
Social Networks ◽  
Growth Rate ◽  
Big Data ◽  
Data Processing ◽  
New Technologies ◽  
Large Data ◽  
Modern Society ◽  
Information Flows ◽  
Professional Activities ◽  
The Past

The growth rate of these enterprises has increased significantly in the last decade. Research has shown that over the past two decades, the amount of data has increased approximately tenfold every two years - this exceeded Moore's Law, which doubles the power of processors. About thirty thousand gigabytes of data are accumulated every second, and their processing requires an increase in the efficiency of data processing. Uploading videos, photos and letters from users on social networks leads to the accumulation of a large amount of data, including unstructured ones. This leads to the need for enterprises to work with big data of different formats, which must be prepared in a certain way for further work in order to obtain the results of modeling and calculations. In connection with the above, the research carried out in the article on processing and storing large data of an enterprise, developing a model and algorithms, as well as using new technologies is relevant. Undoubtedly, every year the information flows of enterprises will increase and in this regard, it is important to solve the issues of storing and processing large amounts of data. The relevance of the article is due to the growing digitalization, the increasing transition to professional activities online in many areas of modern society. The article provides a detailed analysis and research of these new technologies.

scholarly journals International Market Entry Strategies: Relational, Digital, and Hybrid Approaches

2018 ◽  
Vol 26 (1) ◽  
pp. 30-60 ◽  
Author(s):  
George F. Watson ◽  
Scott Weaven ◽  
Helen Perkins ◽  
Deepak Sardana ◽  
Robert W. Palmatier
Keyword(s):  
Market Entry ◽  
New Technologies ◽  
International Market ◽  
Business Environment ◽  
Internet Technology ◽  
Global Business ◽  
The Past ◽  
Hybrid Approaches ◽  
Entry Strategies ◽  
Relational Strategies

The adoption of digital communications, facilitated by Internet technology, has been among the most significant international business developments of the past 25 years. This article investigates the effect of these new technologies and the changing global business environment to understand how relational approaches to international market entry (IME) are changing in light of macro developments. Despite substantial resources in business practice dedicated to combining relational strategies in digital settings, this analysis of extant literature reveals that fewer than 3% of peer-reviewed research articles in the international marketing domain examine digital contexts. To address this gap, the authors assess 25 years of literature to provide (1) a description of the evolution of IME research; (2) a review and synthesis of pertinent literature that adopts relational, digital, and hybrid approaches to IME; (3) a taxonomy of IME strategies; and (4) directions for further research.

Recently-Developed Aluminium Solutions for Aerospace Applications

2006 ◽  
Vol 519-521 ◽  
pp. 1271-1278 ◽  
Author(s):  
Timothy Warner
Keyword(s):  
New Technologies ◽  
Damage Tolerance ◽  
Grain Structure ◽  
Space Applications ◽  
Metallic Structures ◽  
Performance Improvements ◽  
The Past ◽  
Aerospace Applications ◽  
Aerospace Alloys ◽  
Damage Tolerant

Two principal approaches are available to materials’ engineers to improve the overall cost-weight balance of metallic airframe structures: improving alloy performance and optimising materials’ utilisation. Although both approaches have been successful in the past, they are most effective when applied concomitantly. The Aluminium industry has a long record of improving aerospace alloys’ performance. Nevertheless, even in apparently well-explored alloy systems such as the 7xxx family, products with improved damage tolerance-strength balances have recently been developed, thanks to an improved understanding of the optimum Zn-Mg-Cu combinations for the required property balances but also to developments in casting capability. Novel dispersoids and dispersoid combinations have enabled further improvements of the performance of existing alloy families. For example, appropriate Sc and Zr additions have a significant impact on the grain structure of 2xxx alloys and thus on performance. Another high potential approach for alloy performance improvements is the optimisation of Al-Cu-Li-(Mg-Ag-Zn) alloys. These so-called “third generation Al-Li alloys” were principally developed for military and space applications; in order to meet the demands of future commercial airframes, more damage tolerant variants are being developed. AA2198 and AA2050 are used to illustrate the potential of these higher damage tolerance Al-Cu-Li alloys. However, materials performance improvements are only part of the potential developments of metallic solutions for airframes. Further gains of a similar magnitude in component weight and cost can be achieved by applying new technologies and new design solutions to metallic structures. The future of metallic airframes will depend on the concomitant application of both these approaches.

scholarly journals DECLINE OF CLINICAL ART AND TECNOLOGICAL MEDICINE BOOM

2021 ◽  
pp. 123-133
Author(s):  
José Antonio Rodríguez Montes
Keyword(s):  
Physical Examination ◽  
Medical History ◽  
Medical Practice ◽  
New Technologies ◽  
Clinical Skills ◽  
Treatment Plan ◽  
Correct Diagnosis ◽  
Bedside Teaching ◽  
The Past

Currently there is a consensus that the clinical art have been greatly deteriorating during the past 50 years. This problem has raised worldwide attention through as increase in publications, courses, symposia and congress. The erosion of bedside teaching and the consequent decline of clinical skills, notably wrongfull and inadequate use of new technologies. At as result, it becomes difficult if not impossible obtain an appropiate collection of the synptoms sufferick for the sick. Together with the medical history, the physical examination is mandatory for the correct diagnosis and developing the treatment plan. In this paper, the decline of clinical art is exposed and how this ancient heritage of medical practice can be recovered.

scholarly journals The Idea of Russian Symbolism about the Synthesis of Cultural Forms in the Context of Postmodern Culture

ICONI ◽  
2021 ◽  
pp. 126-136
Author(s):  
Nadezhda A. Tsareva ◽  
Keyword(s):  
Twentieth Century ◽  
Cultural Change ◽  
Information Technologies ◽  
New Technologies ◽  
The Past ◽  
Russian Symbolism ◽  
Postmodern Art ◽  
Cultural Forms ◽  
Synthetic Media ◽  
Integrity Of Life

The relevance of the topic is due to the attention to trends in the development of culture. The synthesis of cultural forms is one of the important factors in the dynamics of culture. The teaching of Russian symbolism about the synthesis of cultures was analyzed in the scientifi c literature of the entire twentieth century. The novelty of the research is to compare the idea of art synthesis in the early twentieth and twenty-fi rst centuries. Two aspects of the idea of synthesis are considered: 1) the relevance of the idea of art synthesis in the postmodern era; 2) music and the visual series as organizing centers of art synthesis in the era of information technology. The purpose of this article is to examine the teaching of Russian symbolism about the integration of various forms of art and the features of synthesis in the postmodern era. The idea of integrating cultural forms was one of the key elements in Russian symbolism at the beginning of the twentieth century and was interpreted as a real prospect for the development of culture. In a broad sense, synthesis in symbolism meant the integrity of life, the integration of all spheres of human activity, the “organic connection” of cultures of the past and present. The synthesis can be realized on the basis of the art of symbolism, which can create a new culture. The synthesis of arts was understood as the beginning of the formation of a new culture. The core of the synthesis of arts, the symbolists saw music. Postmodern art is characterized by synthetism. Computer and information technologies create new forms of synthetic media art. The video series becomes the center of integration construction of postmodern audiovisual culture forms. The symbolist idea of the synthesis of arts as the beginning of cultural change in the postmodern era remains a utopian project. But the creation of new art forms in postmodern culture i s based on integration. New technologies are becoming a factor that determines the specifi cs of the synthesis of arts and infl uences the dynamics of culture. Both in Russian symbolism and in modern art, the goal of art synthesis is to present an integral image of the world, to form a system of worldview attitudes.

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