scholarly journals Clinical utility of chromogranin a and octreotide in large cell neuro endocrine carcinoma of the uterine corpus

Rare Tumors ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 129-131 ◽  
Author(s):  
Shohreh Shahabi ◽  
Ilenia Pellicciotta ◽  
June Hou ◽  
Sarah Graceffa ◽  
Gloria S. Huang ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Genital Tract ◽  
Clinical Utility ◽  
Treatment Options ◽  
Female Genital Tract ◽  
Large Cell ◽  
Optimal Management ◽  
Uterine Corpus ◽  
Endocrine Carcinoma ◽  
Female Genital

Primary neuroendocrine tumors of the female genital tract have been described in the cervix, ovaries and uterus. Large cell neuroendocrine carcinoma (LCNC) of the uterine corpus is the least common and appears to behave the most aggressively. We report a rare case of a large cell neuroendocrine tumor of the endometrium. These tumors are not well characterized, unlike neuroendocrine tumors of the uterine cervix. Consequently, the optimal management remains still unclear. The treatment of our case consisted of surgery, radiotherapy, chemotherapy, and octreotide. Despite the aggressive treatment, the patient died of disease progression 12 months after the initial diagnosis. We discuss the diagnosis, prognosis, and treatment options for LCNC of the genital tract, and potential future therapeutics.

scholarly journals NEUROENDOCRINE TUMORS OF THE CERVIX

2020 ◽  
Vol 19 (5) ◽  
pp. 97-107
Author(s):  
K. V. Safronova ◽  
A. S. Artemieva ◽  
A. O. Nuganen ◽  
G. F. Kutusheva ◽  
D. A. Chuglova ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Neuroendocrine Carcinoma ◽  
Clinical Symptoms ◽  
Case Reports ◽  
Treatment Options ◽  
Female Genital Tract ◽  
Large Cell ◽  
Cochrane Library ◽  
Stage Iiia ◽  
Treatment Standards

The purpose of the study was to summarize the available data on etiology, diagnosis, clinical symptoms and signs as well as on various approaches to the treatment of neuroendocrine cervical tumors.Material and Methods. The relevant sources were searched in the PubMed and cochrane Library systems, and publications from 1980 to 2019 were analyzed, 53 of which were used to write this review. We also included 6 case reports from N.N. Petrov National Research Center of Oncology.Results. Neuroendocrine tumors (NETs) are extremely rare and aggressive malignancies of the female genital tract, among which NETs of the cervix are the most common. Due to the rarity of these tumors, there are currently no treatment standards based on prospective, well-planned clinical trials. For these reasons, NETs present a significant therapeutic challenge for clinicians. Case reports. Six patients ranged in age from 32 to 71 years, with a median age of 46 years, were diagnosed with large-cell neuroendocrine carcinoma (4 patients) and small-cell neuroendocrine carcinoma (2 patients). One patient with stage IIIA dropped out of the follow-up schedule. Out of 5 followed up patients, 2 patients with stage IIIA and IIB died of disease progression after 6 and 11 months, respectively. One patient with stage IB1 is in remission for 16 months. Two patients with stage IIB continue to receive primary treatment.Conclusion. Neuroendocrine carcinoma of the cervix is a rare variant of cervical cancer. The choice of treatment options is decided only by a multidisciplinary team of doctors, and further research is required. 

scholarly journals Diagnosis of Primary Langerhans Cell Histiocytosis of the Vulva in a Postmenopausal Woman

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Sefa Kurt ◽  
Mehmet Tunc Canda ◽  
Aycan Kopuz ◽  
Dudu Solakoglu Kahraman ◽  
Abdullah Tasyurt
Keyword(s):  
Differential Diagnosis ◽  
Postmenopausal Woman ◽  
Rare Disease ◽  
Genital Tract ◽  
Langerhans Cell Histiocytosis ◽  
Treatment Options ◽  
Female Genital Tract ◽  
Langerhans Cell ◽  
Pathologic Diagnosis ◽  
Female Genital

Langerhans cell histiocytosis (LCH) is a very rare disease of female genital tract, most commonly seen in vulva and unusual in postmenopausal period. Herein, we report the 8th case of pure vulvar LCH in a postmenopausal woman. We pay attention to the differential diagnosis in postmenopausal state, features of pathologic diagnosis, and treatment options.

A population-based study of malignant neuroendocrine tumors of the female genital tract

2016 ◽  
Vol 141 ◽  
pp. 108
Author(s):  
W. Hendrickson-Cahill ◽  
N.M. Tierney ◽  
C.C. Saenz ◽  
M.T. McHale ◽  
S.C. Plaxe
Keyword(s):  
Neuroendocrine Tumors ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Population Based ◽  
Population Based Study ◽  
Female Genital

Microsatellite instability in large cell neuroendocrine carcinoma of the female genital tract

2009 ◽  
Vol 55 (5) ◽  
pp. 621-624 ◽  
Author(s):  
Paulette Mhawech-Fauceglia ◽  
Ada Chan ◽  
Bernadette Keitz ◽  
Shashikant Lele ◽  
Richard T Cheney ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Neuroendocrine Carcinoma ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Female Genital
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