scholarly journals Oxidative stress and anabolic hormones in back pain: Current concept and preliminary analysis in male cohort

2020 ◽  
Author(s):  
Edoardo Vergani ◽  
Carmine Bruno ◽  
Andrea Silvestrini ◽  
Elisabetta Meucci ◽  
Luca Proietti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Back Pain ◽  
Inverse Correlation ◽  
Medical Problem ◽  
Significant Inverse Correlation ◽  
Anabolic Hormones ◽  
Total Antioxidant ◽  
Male Cohort ◽  
Group A ◽  
Group B

Back Pain (BP) is a common medical problem; anabolic hormones, through the modulation of oxidative stress (OS), could influence fracture risk. We evaluated the prevalence of anabolic hormonal deficiencies and their relationship with OS in males with BP, associated or not to nontraumatic fractures. 49 males with BP, from 36 to 80 years, were divided in two groups according to radiological evidence of nontraumatic fractures; group A (n=25): non-fractured; group B (n=24): fractured. A different prevalence of hormonal deficits was observed: 24% of hypotestosteronemia in A, 0% in B; 16% of GHD in A, 29% in B; Total Antioxidant Capacity (TAC) showed a trend toward higher levels in B. In A, despite lower TAC, a significant inverse correlation was present between TAC and IGF-1. A greater prevalence of GHD in patients with vertebral fractures was seen and, in a subgroup, OS could mediate the deleterious effects of hyposecretory GH state.

scholarly journals Correlation of vitamin D level with its related biochemical parameters and impact of different treatment regimens on their correction

2020 ◽  
Vol 8 (1) ◽  
pp. 86
Author(s):  
Amit Gupta ◽  
Sachin Kumar
Keyword(s):  
Biochemical Parameters ◽  
Inverse Correlation ◽  
Ultraviolet Rays ◽  
P Value ◽  
Significant Inverse Correlation ◽  
Treatment Groups ◽  
Treatment Regimens ◽  
Before And After ◽  
Group A ◽  
Group B

Background: Vit D is a fat-soluble vitamin that is produced when ultraviolet rays from sunlight strike the skin and trigger vit D synthesis. Aims and Objectives of the study were to find out the correlation of vit D level with its related biochemical parameters and impact of two different treatment regimens on their correction. Methods: A total of 107 patients were followed up out of which 89 were vit D deficient and rest were vit D insufficient. Results: Mean age of the patients was 6.11±4.49 and males comprised 66%. Mean BMI of children included in group A, B and C was 19.40±2.69, 19.60±3.18 and 20.95±3.72 kg/m2 respectively. Vit D levels at baseline had a significant inverse correlation with ALP (r=-0.27, p value=0.008).  Before and after comparison of mean serum calcium levels revealed significant improvement in both the treatment groups. Severity of vit D deficiency, at baseline, 9.10, 77.30 and 13.60% of patients had vit D levels of less than 5, 5 to 15 and more than 15 for group A respectively. In group B at baseline, 6.70, 71.10 and 22.20% of patients had vit D levels of less than 5, 5 to 15 and more than 15 respectively.Conclusions: Present study found that 60,000 IU/week and dose of 2000 IU/day for infants or 5000 IU/day for 1 to 18 years of age, along with 500 to 800 mg oral calcium for 6 to 8 weeks can result in correction of vit D deficiency.

Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Akinleye Stephen Akinrinde ◽  
Halimot Olawalarami Hameed
Keyword(s):  
Oxidative Stress ◽  
Total Protein ◽  
Therapeutic Index ◽  
Control Treatment ◽  
Control Group ◽  
Protective Effects ◽  
Serum Total Protein ◽  
Significant Amelioration ◽  
Group A ◽  
Group B

Abstract Objectives This study examined the possible protective roles of exogenous glycine (Gly) and L-Arginine (l-Arg) against Diclofenac (DIC)-induced gastro-duodenal damage in rats. Methods Rats were divided into Group A (control), Group B (DIC group) and Groups C–F which were pre-treated for five days with Gly1 (250 mg/kg), Gly2 (500 mg/kg), l-Arg1 (200 mg/kg) and l-Arg2 (400 mg/kg), respectively, before co-treatment with DIC for another three days. Hematological, biochemical and histopathological analyses were then carried out. Results DIC produced significant (p<0.05) reduction in PCV (13.82%), Hb (46.58%), RBC (30.53%), serum total protein (32.72%), albumin (28.44%) and globulin (38.01%) along with significant (p<0.05) elevation of serum MPO activity (83.30%), when compared with control. In addition, DIC increased gastric H2O2 and MDA levels by 33.93 and 48.59%, respectively, while the duodenal levels of the same parameters increased by 19.43 and 85.56%, respectively. Moreover, SOD, GPx and GST activities in the DIC group were significantly (p<0.05) reduced in the stomach (21.12, 24.35 and 51.28%, respectively) and duodenum (30.59, 16.35 and 37.90%, respectively), compared to control. Treatment with Gly and l-Arg resulted in significant amelioration of the DIC-induced alterations although l-Arg produced better amelioration of RBC (29.78%), total protein (10.12%), albumin (9.93%) and MPO (65.01%), compared to the DIC group. The protective effects of both amino acids against oxidative stress parameters and histological lesions were largely similar. Conclusions The data from this study suggest that Gly or l-Arg prevented DIC-induced gastro-duodenal toxicity and might, therefore be useful in improving the therapeutic index of DIC.

Effects of Tailored Motor Control Rehabilitation Vs Standard Exercise Program in Management Of Chronic Nonspecific LBP

2021 ◽  
Vol 15 (11) ◽  
pp. 3219-3221
Author(s):  
Maryam Liaquat ◽  
Wajida Perveen ◽  
Danish Hassan ◽  
Misbah Amanat Ali ◽  
Muhammad Akhtar ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Motor Control ◽  
Back Pain ◽  
Clinical Study ◽  
Exercise Program ◽  
Low Back ◽  
Randomized Clinical Study ◽  
Lower Back ◽  
Group A ◽  
Group B

Lower back pain is one of the most common problems in adults all over the world, and chances of having back pain increases with the age. Objectives: To determine the effect of tailored motor control rehabilitation versus standard exercise program in chronic nonspecific lower back pain. Study Design: Non randomized clinical study. Methodology: A non randomized clinical study was conducted in six-month during 2018 after ethical approval. 40 patients were enrolled through non-probability purposive sampling technique and allocated into two groups (Group A & B). Informed consent was obtained. Individuals between twenty to forty years with chronic nonspecific low back pain with intensity at least 3 on a 10cm visual analog scale (VAS) were included and individuals with past history of trauma of the spine and hip and with any red flags were excluded. Outcomes were measures by Modified Oswestry Disability Index (MODI) and Visual Analogue Scale (VAS). Statistical analysis: Data was analyzed by SPSS software, version 19 as qualitative variables were expressed as mean ± SD. Independent sample T test was also applied. Results: The mean age Group A was 29.05±8.58 and Group B, was 32.05±6.53 years. The result shows that there was a significant difference in outcomes among tailored motorcontrol rehabilitation (Group A) and standard exercise program (Group B). Conclusion: We concluded that motor control rehabilitation was more effective than standard exercise program in decreasing low back pain and improving quality of life. Key Words: Low Back Pain, Tailored Motor Control Rehabilitation, Standard Exercise Program and Modified Oswastry Disability Index.

EFFECT OF ISOMETRIC AND ISOTONIC EXERCISE TRAINING ON CORE MUSCLE IN SUBJECTS WITH NON SPECIFIC LOW BACK PAIN

2017 ◽  
Vol 10 (6) ◽  
pp. 308
Author(s):  
Bijal Majiwala ◽  
Trupti Warude ◽  
Amrutkuvar Pawar
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Functional Disability ◽  
Isometric Exercise ◽  
Low Back ◽  
Endurance Test ◽  
Isotonic Exercise ◽  
Group A ◽  
Pre Treatment ◽  
Group B

Objective: To compare the effects of isometric (stability) and isotonic training on core muscle in patients with non-specific low back pain on pain, endurance, and functional disability.Methods: Forty participants of both genders aged between 20 and 35 years suffering from non-specific low back pain were taken and equally divided into two groups: Group A isometric exercise and Group B isotonic exercise, both the group received baseline treatment of transcutaneous electrical nerve stimulation and hot moist pack. Outcomes measure visual analog scale, endurance test, and modified Oswestry disability index were used the pre-treatment and at the end of 4 weeks.Results: Experiment of both the groups showed a non-significant improvement in pain, endurance, and functional disability. Except for extensor endurance test which shows significant different in Group A.Conclusion: Both isometric and isotonic exercises are equally effective in reducing pain, increase endurance, and improve functional disability in patients with non-specific low back pain.

scholarly journals To Study the effect of Traditional Back Exercises vs Exercise Ball Exercise on Pain Intensity, Core Endurance and Limitation of Activities in Individuals with Nonspecific Low Back Pain: A Comparative Study

2021 ◽  
pp. 117-123
Author(s):  
Jay Kumar Soni ◽  
Edrish Contractor
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Comparative Study ◽  
Pain Intensity ◽  
Core Stability ◽  
Low Back ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Swiss Ball

Aims: Non specific Low back pain is defined as pain without any known pathology which affects almost all the leading occupation where body's awkward posture, twisting and stress forces are commonly encountered across the globe and it is highly prevalent 60% to 70% in a year. Studies have shown various exercise regimen individual effect on the same but superiority of regimen out of these is not clear. Study Design: Comparative Study Place and Duration of Study: Ahmedabad Institute of Medical Sciences, Duration 2013-15 Objective: To assess and compare the effect of core stability exercise, back school program and Swiss ball exercise on Pain, core endurance and Functional disability. Methodology: A group of 24 patients having non-specific low back pain between age groups 18-40 were randomly selected and allocated in to two groups. Group A(n=12) received traditional exercise whereas Swiss ball exercise was given to Group B(n=12). The subjects were treated for two weeks. Baseline data for VAS, Core endurance and MODI were taken on day1 and at the end of two weeks Result: The results were analyzed by wilcoxon signed rank test within both groups. Both groups showed significant improvement in VAS, core endurance and MODI at the end of 2weeks.Comparison between both the Group A and Group B was done by Mann- whitney U test and statistically no significant difference was seen in VAS, core endurance and MODI between the groups Conclusion: The study concluded that both the exercises are equally effective in reducing pain intensity, improves core endurance and functional status in subjects with non specific low back pain

scholarly journals EFFECTIVENESS OF LUMBAR MANIPULATION (HIGH VELOCITY LOW AMPLITUDE) FOR THE TREATMENT OF LOW BACK PAIN IN COMPARISON TO BACK STRETCHING EXERCISES

2012 ◽  
Vol 1 (1) ◽  
pp. 23-27
Author(s):  
Syed Abid Mehdi Kazmi ◽  
Nabiha Mujahid Faruq ◽  
Sumaira Imran Farooqui ◽  
Jharna Devi
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
High Velocity ◽  
Low Back ◽  
Before And After ◽  
History Of ◽  
Group A ◽  
Group B ◽  
Low Amplitude ◽  
Stretching Exercises

OBJECTIVES To assess the effectiveness of lumbar manipulation (high velocity low amplitude) for the treatment of low back pain in comparison to back stretching exercises. Randomized Control Trial (Experimental Study) The study was conducted on 200 patients at the Physiotherapy Department of Ziauddin Hospital among patients with history of low back pain of acute, sub acute or chronic origin. In this study, patients were divided into two groups, group A and group B equally. Group A of 100 patients received Lumbar Manipulation (High Velocity Low Amplitude) and at the same time Group B of 100 patients were treated by back stretching exercises. A pre tested and structured questionnaire was used to collect data. Data was entered and analyzed by using SPSS. Pain was measured on Visual Analogue Scale before and after the given treatment. The study showed significant results for both the interventions in the treatment of low back pain but Lumbar Manipulation has been more effective in different types of low back pain while stretching exercises are less effective. On the basis of this study, we are very confident that lumbar manipulation is more effective for the treatment of low back pain compared to back stretching

scholarly journals Potential Role of Red Palm Oil Supplemented Diet on Oxidative Stress Enzymes in Plasmodium Berghei Induced Malaria

2021 ◽  
Author(s):  
Temitope Daniel Adeleke ◽  
Olawale Abiodun Adejumobi ◽  
Franklin Folasele Akinola ◽  
Oluwatosin Abidemi Salau ◽  
Oyeronke Suebat Uthman-Izobo
Keyword(s):  
Oxidative Stress ◽  
Dietary Intake ◽  
Palm Oil ◽  
Plasmodium Berghei ◽  
Malaria Parasite ◽  
Red Palm Oil ◽  
Oxidative Stress Enzymes ◽  
Stress Enzymes ◽  
Group A ◽  
Group B

AbstractBackgroundMalaria parasites are very vulnerable to oxidative stress during the part of their life cycle when they inhabit the erythrocytes. Studies have shown that dietary intake of antioxidant plays a role in stabilizing oxidative stress.MethodsThe objective of this research work was to examine the antioxidative effect of red palm oil on Plasmodium berghei malaria induced oxidative stress. Sixty (60) mice were distributed into five groups. Group A served as the negative control (healthy mice with normal feed); group B as positive control (healthy mice fed with red palm oil without malaria parasite.while the other groups (C to E) served as the test groups. Group C served as group of healthy mice fed with red palm oil (pelletized), infected with malaria parasite without antimalaria drug. Group D served as group of healthy mice fed with red palm oil (pelletized), infected with malaria parasite and treated with amodiaquine. Group E served as group of healthy mice fed with normal feed, infected with malaria parasite and treated with amodiaquine. The parasitemia levels were estimated on days 1,4 and 5. The activity of oxidative stress enzymes biomarkers were determined spectrophotometrically.ResultGroup A showed a statistically significant increase in the activity of SOD (1.90 ± 0.16 units/mg protein), GST (1.68 ± 0.086 units/L) compared to group C, SOD (3.54 ± 0.83 units/mg protein), GST (2.12 ± 0.20 units/L). Group B showed a statistical significant decrease in the activities of SOD (3.22 ± 0.33 units/mg protein), Catalase (49.11 ± 2.35 µmol/min), GSH-R (31.50 ± 2.48 units/L) compared to group E, SOD (2.18 ± 0.39 units/mg protein), Catalase (44.07 ± 3.88 µmol/min), GSH-R (27.75 ± 1.64 units/L).ConclusionThe dietary intake of red palm oil helps to reduce free radical mediated injury to the tissue thus preventing oxidative stress induced by malaria or any other factors.

scholarly journals Oxidative Stress Levels in Orthodontic Patients and Efficacy of Antioxidant Supplements in Combating Its Effects- A Randomized Clinical Study

2019 ◽  
Vol 9 (2) ◽  
pp. 29-34
Author(s):  
Sheetal Yamyar ◽  
Suchita Daokar
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Orthodontic Appliances ◽  
Randomized Clinical Study ◽  
Gingival Health ◽  
Orthodontic Patients ◽  
Group A ◽  
Antioxidant Supplements ◽  
Group B

Introduction: Orthodontic appliances are considered to be biocompatible although adverse effects attributed to release of nickel ion which are free radicals in oral cavity. These free radical produce damages both in cellular and extracellular components phospholipid membrane, proteins, mitochondrial and nuclear DNA leading to Oxidative stress which is normally counter balanced by the action antioxidant mechanisms. However in higher concentrations of free radicals resulting in cellular death and apoptosis Orthodontic appliances such as brackets, wire, resins has considered as potential allergen leading to release of free radicals. The study was conducted to determine and compare the role of oxidative stress and role of antioxidants in saliva of patients undergoing fixed orthodontic appliances therapy at different time intervals. Materials & Method: A double-blinded, parallel, randomized clinical study was designed consisting of 40 healthy participants, aged 15-30yrs. The samples were divided into two groups Group A without antioxidants supplements and Group B with antioxidants supplements. Salivary MDA levels and gingival health index was recorded at different time intervals from each group. Salivary Lipid peroxidation (Malondialdehyde) level was estimated using Thiobarbituric acid (TBA) method and gingival status was investigated using Silness & Loe gingival index. Intragroup and intergroup comparison was statistically analyzed using student’s paired T test. Result: Increased salivary MDA levels and mild to moderate amount of gingivitis is seen in both groups. This is more pronounced after 24 hours of appliance placement. Improvement in salivary MDA levels and gingival health status is observed during the course of treatment, In Group B the salivary MDA levels and gingival health index score reached below their pretreatment values. However even after a span of 3 months the levels remained higher to their base values in Group A. Conclusion: Improvement in salivary MDA levels and gingival health status is observed following antioxidant therapy during course of treatment, indicating combating nature of antioxidant supplements in orthodontic patients.

scholarly journals EFFICACY AND TOLERABILITY OF FLUPIRTINE VERSUS TRAMADOL IN THE TREATMENT OF MODERATE CHRONIC LOW BACK PAIN

2019 ◽  
pp. 84-87
Author(s):  
VINEELA KARTHIK NAGURI ◽  
RAVI BABU KOMARAM ◽  
TAMILISETTI VIDYA SAGAR
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Adverse Drug Reactions ◽  
Tertiary Care ◽  
Care Hospital ◽  
Low Back ◽  
Drug Reactions ◽  
Study Results ◽  
Group A ◽  
Group B

Objective: The objective of the study was to assess and compare the efficacy and tolerability of flupirtine versus tramadol in patients with chronic moderate low back pain (LBP). Materials and Methods: A prospective study was conducted in the outpatient department of orthopaedics at tertiary care hospital, Rajamahendravarm. After meeting the inclusion criteria, a total of 60 patients were randomly allocated to tablet flupirtine 100 mg in Group A and tablet tramadol 50 mg in Group B. The efficacy of the study drugs was assessed at baseline and the end of treatment by numerical rating scale11, visual analog scale-100 mm, physician’s, and patient’s global assessment. Statistical analysis was done using paired and unpaired t-test and data were presented as mean±standard deviation. Adverse drug reactions were monitored during the treatment. Results: The study results showed that 90% of the patients in Group A and 78% of the patients in Group B had shown a good response to their respective drugs. 30% of flupirtine group patients reported adverse drug reactions which were mild. Conclusion: Both the drugs are effective in the treatment of moderate chronic LBP, but the advantage of flupirtine was, the incidence of adverse drug reactions was less when compared to tramadol group.

scholarly journals Effects Of Transcutaneous Electrical Nerve Stimulation (Tens) On Patients With Acute Low Back Pain

2012 ◽  
Vol 7 (2) ◽  
pp. 29-32
Author(s):  
B Ahmed ◽  
S Alam ◽  
I Rashid ◽  
N Rahman ◽  
A Rahman ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Nerve Stimulation ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Significant Proportion ◽  
Low Back ◽  
Electrical Nerve Stimulation ◽  
Acute Low Back Pain ◽  
Group A ◽  
Group B

Background: Acute low back pain (LBP) affects a significant proportion of the population. Transcutaneous electrical nerve stimulation (TENS) was introduced more than 30 years ago as an adjunct to the pharmacological management of pain. However, despite its widespread use, the usefulness of TENS in LBP is still controversial. Introduction: LBP is a common problem in Bangladesh. Acute LBP is usually defined by a period of complaints of LBP of six weeks or shorter. TENS may improve acute LBP. Objective: To evaluate the effectiveness of TENS on acute LBP and also to ensure the patients wellbeing by shortening recovery time who have acute LBP. Methods: A prospective study was carried out in the Department of Physical Medicine and Rehabilitation, Bangubandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from July 2008 to December 2008. The patients were divided into two groups (A and B). Patients of Group A (30 patients) were treated with TENS, Non-steroidal anti-inflammatory drugs (NSAIDs) and activities of daily living (ADLs) instruction. Patients of group B (28 patients) were treated with NSAIDs and ADLs instructions. Results: A total of 58 Patients of acute LBP were included in this study. The mean age of the patients was 38.5 ± 9.01 years. Main causes of pain were muscle strain (39.65%), nonspecific LBP (22.41%), prolapsed lumber intervertebral disc (17.24%), lumbar spondylosis (13.79%) and sciatica (6.91%). After treatment the result was compared and student's 't' test was done to see the level of significance. Method was found significant after treatment (p<0.05). Twenty four (80%) patients were improved in group A and 18 (64.28%) patients in group B. Patient compliances of group A were better than that in group B. Conclusion: Effect of TENS on patients with acute low back pain is beneficial. DOI: http://dx.doi.org/10.3329/jafmc.v7i2.10393 JAFMC 2011; 7(2): 29-32

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