scholarly journals Invasive candidiasis presenting multiple pulmonary cavitary lesions on chest computed tomography

2015 ◽  
Vol 10 ◽  
Author(s):  
Yuichiro Yasuda ◽  
Kazunori Tobino ◽  
Mina Asaji ◽  
Yoshikazu Yamaji ◽  
Kosuke Tsuruno
Keyword(s):  
Computed Tomography ◽  
Invasive Candidiasis ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Pulmonary Aspergillosis ◽  
Chest Computed Tomography ◽  
Remarkable Improvement ◽  
First Case ◽  
Ct Finding ◽  
Chest Ct Scan

We herein report a case of invasive candidiasis presenting rare findings on chest computed tomography (CT). The chest CT scan showed multiple small cavitary lesions and nodules with surrounding ground-glass opacity, and also bilateral pleural effusion. Although this CT finding is thought as specific for pulmonary aspergillosis, two sets of blood culture specimens were drawn which yielded Candida albicans  in our case. Antifungal therapy was started and the chest CT findings showed a remarkable improvement. To our knowledge, this is the first case report describing multiple pulmonary cavitary lesions in invasive candidiasis.

Chest Computed Tomography Findings in a Case Series of Coronavirus Disease 2019 (COVID-19) Patients at Siriraj Hospital

2021 ◽  
Vol 104 (5) ◽  
pp. 866-871
Keyword(s):  
Computed Tomography ◽  
Medical Records ◽  
Case Series ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Ground Glass ◽  
Chest Computed Tomography ◽  
Ct Findings ◽  
Siriraj Hospital ◽  
Chest Ct Scan

Background: Recent evidence has demonstrated the high sensitivity of chest computed tomography (CT) in coronavirus disease 2019 (COVID-19) case detection. However, considering the cost and infection control issues, the experience of chest CT for COVID-19 diagnosis in Thailand is still limited. Objective: To present the characteristics of chest CT findings in COVID-19 patients at Siriraj Hospital and compare them with other reports. Materials and Methods: The authors retrospectively reviewed the COVID-19 patients’ medical records between April and May 2020. All cases with the presence of chest CT performed during admission were recruited. Clinical data were retrieved from the patients’ medical records. All chest imaging results were reported by consensus between the authors. Results: From 103 cases, four cases with a chest CT scan during the admission were recruited. Consistent with previous reports, the common chest CT findings included a ground-glass opacity and consolidation with bilateral involvement. A round-shaped ground-glass opacity or consolidation was evidenced in half of the cases. The only case with the presence of chest CT scan, which was done 77 days after the onset of COVID-19 symptoms, revealed resolution of the abnormal findings. Conclusion: Chest CT findings in four COVID-19 cases at Siriraj Hospital are consistent with previous reports. Common findings include bilateral ground-glass opacity and consolidation. Keywords: COVID-19, SARS-CoV-2, Computed tomography, Case series

scholarly journals Clinical outcomes of hemodialysis patients infected with severe acute respiratory syndrome coronavirus 2 and impact of proactive chest computed tomography scans

2020 ◽  
Vol 13 (3) ◽  
pp. 328-333 ◽  
Author(s):  
Rui Wang ◽  
Hong He ◽  
Cong Liao ◽  
Hongtao Hu ◽  
Chun Hu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Invasive Mechanical Ventilation ◽  
Case Series ◽  
Ground Glass Opacity ◽  
High Sensitivity ◽  
Chest Ct ◽  
Maintenance Hemodialysis ◽  
Rt Pcr ◽  
Chest Computed Tomography ◽  
Reactive Protein

Abstract Background Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that first manifested in humans in Wuhan, Hubei Province, China, in December 2019, and has subsequently spread worldwide. Methods We conducted a retrospective, single-center case series of the seven maintenance hemodialysis (HD) patients infected with COVID-19 at Zhongnan Hospital of Wuhan University from 13 January to 7 April 2020 and a proactive search of potential cases by chest computed tomography (CT) scans. Results Of 202 HD patients, 7 (3.5%) were diagnosed with COVID-19. Five were diagnosed by reverse transcription polymerase chain reaction (RT-PCR) because of compatible symptoms, while two were diagnosed by RT-PCR as a result of screening 197 HD patients without respiratory symptoms by chest CT. Thirteen of 197 patients had positive chest CT features and, of these, 2 (15%) were confirmed to have COVID-19. In COVID-19 patients, the most common features at admission were fatigue, fever and diarrhea [5/7 (71%) had all these]. Common laboratory features included lymphocytopenia [6/7 (86%)], elevated lactate dehydrogenase [3/4 (75%)], D-dimer [5/6 (83%)], high-sensitivity C-reactive protein [4/4 (100%)] and procalcitonin [5/5 (100%)]. Chest CT showed bilateral patchy shadows or ground-glass opacity in the lungs of all patients. Four of seven (57%) received oxygen therapy, one (14%) received noninvasive and invasive mechanical ventilation, five (71%) received antiviral and antibacterial drugs, three (43%) recieved glucocorticoid therapy and one (14%) received continuous renal replacement therapy. As the last follow-up, four of the seven patients (57%) had been discharged and three patients were dead. Conclusions Chest CT may identify COVID-19 patients without clear symptoms, but the specificity is low. The mortality of COVID-19 patients on HD was high.

scholarly journals Amiodarone-induced pulmonary toxicity

2011 ◽  
Vol 1 (1) ◽  
pp. 6
Author(s):  
Junichi Ochi ◽  
Minoru Ohkouchi ◽  
Yoshikazu Tsukada ◽  
Shinichiro Tominaga ◽  
Satoshi Takayama ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Medical Records ◽  
Lung Biopsy ◽  
Pulmonary Toxicity ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Chest Computed Tomography ◽  
Ct Findings ◽  
The Mean ◽  
Foamy Macrophages

Amiodarone-induced pulmonary toxicity is a critical and potentially fatal side effect of amiodarone. Our study was designed to reveal its clinical features, including KL-6, as an interstitial marker. The medical records of eight patients (five men and three women) with amiodarone-induced pulmonary toxicity, who had been referred to our hospital, were examined. The mean age at the initiation of amiodarone was 48 years (range, 54-87 years) and mean duration of medication prior to the development of pulmonary toxicity was 18 months (range, 7-33 months). Serum KL-6 was elevated in six of the eight patients with a range of 525-2915 U/mL. Chest computed tomography (CT) findings showed non-segmental consolidation and/or ground glass opacity. Foamy macrophages were found in bronchoalveolar lavage (BAL) fluids of all examined patients and in transbronchial lung biopsy (TBLB) specimens in half of the examined patients. We concluded that serum KL-6, chest CT findings, and foamy macrophages in BAL fluids and TBLB specimens will be helpful for the diagnosis of amiodarone-induced pulmonary toxicity.

scholarly journals Chest Computed Tomography Findings in Asymptomatic Patients with COVID-19

Respiration ◽  
2020 ◽  
Vol 99 (9) ◽  
pp. 748-754 ◽  
Author(s):  
Min Cheol Chang ◽  
Wonho Lee ◽  
Jian Hur ◽  
Donghwi Park
Keyword(s):  
Computed Tomography ◽  
South Korea ◽  
Respiratory System ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Effective Management ◽  
Radiographic Findings ◽  
Chest Computed Tomography ◽  
Asymptomatic Patients ◽  
The Right

<b><i>Background:</i></b> Little is known about the damage to the respiratory system in asymptomatic patients with coronavirus disease (COVID-19). <b><i>Objective:</i></b> Herein, we evaluate the findings of chest computed tomography (CT) and radiography in patients with COVID-19 who were asymptomatic. <b><i>Methods:</i></b> We retrospectively investigated patients with a confirmed diagnosis of COVID-19 but who did not show any symptoms. Among the 139 patients with COVID-19 who were hospitalized in Yeungnam University Hopistal in Daegu, South Korea, 10 (7.2%) were asymptomatic. Their chest CT and radiographic findings were analyzed. <b><i>Results:</i></b> In the results, all patients (100%) had ground-glass opacity (GGO) on chest CT. Further, the GGO lesions were predominantly distributed peripherally and posteriorly in all patients. In 9 (90%) patients, the GGO lesions were combined with reticular opacity. Air bronchogram due to bronchiolectasis surrounded by GGO was observed in 8 patients (80%). Additionally, the lung lesions were dominant on the right side in all patients. <b><i>Conclusions:</i></b> In conclusion, considering our results that the lung is affected in asymptomatic patients, it will be necessary to extend the indications of COVID-19 testing for effective management of COVID-19 during the pandemic.

scholarly journals Specificity of chest computed tomography in COVID-19-associated pneumonia: a retrospective study

2021 ◽  
Vol 49 (1) ◽  
pp. 1-10
Author(s):  
T. A. Korb ◽  
P. V. Gavrilov ◽  
V. Yu. Chernina ◽  
I. A. Blokhin ◽  
O. O. Aleshina ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Ct Scan ◽  
Coefficient Of Variation ◽  
Information Service ◽  
Chest Ct ◽  
Primary Study ◽  
Chest Computed Tomography ◽  
Moscow City ◽  
Attending Physician ◽  
Chest Ct Scan

Aim: To assess the specificity of COVID-19- associated pneumonia detection by radiologists using a chest CT scan.Materials and methods: From mid-February to early March 2020, 65  patients have been retrospectively selected from the Moscow City Clinical Hospital database; all of them had been treated in an inpatient facility with a  verified diagnosis of COVID-19. In addition, 75  patients from the Unified Radiological Information Service have been randomly selected. In December 2019, these outpatients had been sent by an attending physician for a  chest CT scan with suspected pneumonia. The imaging studies showed non-specific inflammation signs in the lungs. All 140  scans were analyzed by seven radiologists from different Russian cities, who independently categorized each study as “COVID-19” or “Other pneumonia”.Results: Chest computed tomography had a  92%  specificity in the differential diagnosis of COVID-19-associated pneumonia, and its specificity in the general population is expected to be at least 80% with a high probability. The inter-rater variability was low (coefficient of variation for specificity 12.6%). The sensitivity in our study was 76.2%, and the coefficient of variation for sensitivity 23.5%. These findings are generally consistent with other studies. The primary study limitation is the absence of a sample with confirmed pneumonia caused by other viruses.Conclusion: Chest CT is highly specific for the detection of COVID-19-associated pneumonia.

scholarly journals Coronavirus disease 2019 (COVID-19) in Italy: features on chest computed tomography using a structured report system

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Grassi Roberto ◽  
Fusco Roberta ◽  
Belfiore Maria Paola ◽  
Montanelli Alessandro ◽  
Patelli Gianluigi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Ground Glass Opacity ◽  
Mean Value ◽  
Chest Ct ◽  
Viral Pneumonia ◽  
Mediastinal Lymphadenopathy ◽  
Rt Pcr ◽  
Chest Computed Tomography ◽  
Trunk Diameter ◽  
Structured Report

Abstract To assess the use of a structured report in the Chest Computed Tomography (CT) reporting of patients with suspicious viral pneumonia by COVID-19 and the evaluation of the main CT patterns. This study included 134 patients (43 women and 91 men; 68.8 years of mean age, range 29–93 years) with suspicious COVID-19 viral infection evaluated by reverse transcription real-time fluorescence polymerase chain reaction (RT-PCR) test. All patients underwent CT examinations at the time of admission. CT images were reviewed by two radiologists who identified COVID-19 CT patterns using a structured reports. Temporal difference mean value between RT-PCRs and CT scan was 0.18 days ± 2.0 days. CT findings were positive for viral pneumonia in 94.0% patients while COVID-19 was diagnosed at RT-PCR in 77.6% patients. Time mean value to complete the structured report by radiologist was 8.5 min ± 2.4 min. The disease on chest CT predominantly affected multiple lobes and the main CT feature was ground glass opacity (GGO) with or without consolidation (96.8%). GGO was predominantly bilateral (89.3%), peripheral (80.3%), multifocal/patching (70.5%). Consolidation disease was predominantly bilateral (83.9%) with prevalent peripheral (87.1%) and segmental (47.3%) distribution. Additional CT signs were the crazy-paving pattern in 75.4% of patients, the septal thickening in 37.3% of patients, the air bronchogram sign in 39.7% and the “reversed halo” sign in 23.8%. Less frequent characteristics at CT regard discrete pulmonary nodules, increased trunk diameter of the pulmonary artery, pleural effusion and pericardium effusion (7.9%, 6.3%, 14.3% and 16.7%, respectively). Barotrauma sign was absent in all the patients. High percentage (54.8%) of the patients had mediastinal lymphadenopathy. Using a Chest CT structured report, with a standardized language, we identified that the cardinal hallmarks of COVID-19 infection were bilateral, peripheral and multifocal/patching GGO and bilateral consolidation with peripheral and segmental distribution.

scholarly journals The Combination of Chest Computed Tomography and Standard Electrocardiogram Provides Prognostic Information and Pathophysiological Insights in COVID-19 Pneumonia

2021 ◽  
Vol 10 (14) ◽  
pp. 3031
Author(s):  
Matteo Bertini ◽  
Emanuele D’Aniello ◽  
Alberto Cereda ◽  
Marco Toselli ◽  
Filippo Maria Verardi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Ct Scan ◽  
Severe Pneumonia ◽  
Chest Ct ◽  
Ratio Test ◽  
Short Term ◽  
Chest Computed Tomography ◽  
Vascular Phenotype ◽  
All Cause Mortality ◽  
Chest Ct Scan

Aims. Several studies have unveiled the great heterogeneity of COVID-19 pneumonia. Identification of the “vascular phenotype” (involving both pulmonary parenchyma and its circulation) has prognostic significance. Our aim was to explore the combined role of chest computed tomography (CT) scan and electrocardiogram (ECG) at hospital admission in predicting short-term prognosis and to draw pathophysiological insights. Methods and Results. We analyzed the chest CT scan and ECG performed at admission in 151 consecutive COVID-19 patients admitted between 20 March and 4 April 2020. All-cause mortality within 30 days was the primary endpoint. Median age was 71 years (IQR: 62–76). Severe pneumonia was present in 25 (17%) patients, and 121 (80%) had abnormal ECG. During a median follow-up of 7 days (IQR: 4–13), 54 (36%) patients died. Deceased patients had more severe pneumonia than survivors did (80% vs. 64%, p = 0.044). ECG in deceased patients showed more frequently atrial fibrillation/flutter (17% vs. 6%, p = 0.039) and acute right ventricular (RV) strain (35% vs. 10%, p < 0.001), suggesting the “vascular phenotype”. ECG signs of acute RV strain (HR 2.46, 95% CIs 1.36–4.45, p = 0.0028) were independently associated with all-cause mortality in multivariable analysis, and in the likelihood ratio test, showed incremental prognostic value over chest CT scan, age, and C-reactive protein. Conclusions. Combining chest CT scan and ECG data improves risk stratification in COVID-19 pneumonia by identifying a distinctive phenotype with both parenchymal and vascular damage of the lung. Patients with severe pneumonia at chest CT scan plus ECG signs of acute RV strain have an extremely poor short-term prognosis.

scholarly journals Chest computed tomography (CT) scan findings in patients with COVID-19: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Mohammad Karimian ◽  
Milad Azami
Keyword(s):  
Computed Tomography ◽  
Ct Scan ◽  
Meta Analysis ◽  
Lower Lobe ◽  
Chest Ct ◽  
Transformation Rule ◽  
Cochrane Library ◽  
Final Report ◽  
Chest Computed Tomography ◽  
Chest Ct Scan

AbstractObjectivesNumerous cases of pneumonia of caused by coronavirus disease 2019 (COVID-19) were reported in Wuhan, China. Chest computed tomography (CT) scan is highly important in the diagnosis and follow-up of lung disease treatment. The present meta-analysis was performed to evaluate chest CT findings in COVID-19 patients.Materials and MethodsAll research steps were taken according to the MOOSE protocol and the final report was based on PRISMA guidelines. Each stage of the study was conducted by two independent authors. We searched the Web of Science, Ovid, Science Direct, Scopus, EMBASE, PubMed/Medline, Cochrane Library, EBSCO, CINAHL and Google scholar databases. The search was conducted on March 20, 2020. Grey literature was searched at medrxiv website. All analyses were performed using Comprehensive Meta-Analysis. The adapted Newcastle Ottawa Scale was used to evaluate the risk of bias. We registered this review at PROSPERO (registration number: CRD42019127858).ResultsFinally, 40 eligible studies with 4,183 patients with COVID-19 were used for meta- analysis. The rate of positive chest CT scan in patients with COVID-19 was 94.5% (95%CI: 91.7-96.3). Bilateral lung involvement, pure ground-glass opacity (GGO), mixed (GGO pulse consolidation or reticular), consolidation, reticular, and presence of nodule findings in chest CT scan of COVID-19 pneumonia patients were respectively estimated to be 79.1% (95% CI: 70.8- 85.5), 64.9% (95%CI: 54.1-74.4), 49.2% (95%CI: 35.7-62.8), 30.3% (95%CI: 19.6-43.6), 17.0% (95%CI: 3.9-50.9) and 16.6% (95%CI: 13.6-20.2). The distribution of lung lesions in patients with COVID-19 pneumonia was peripheral (70.0% [95%CI: 57.8-79.9]), central (3.9% [95%CI: 1.4-10.6]), and peripheral and central (31.1% [95%CI: 19.5-45.8]). The most common pulmonary lobes involved were right lower lobe (86.5% [95%CI: 57.7-96.8]) and left lower lobe (81.0% [95%CI: 50.5-94.7]).ConclusionOur study showed that chest CT scan has little weakness in diagnosis of COVID-19 combined to personal history, clinical symptoms, and initial laboratory findings, and may therefore serve as a standard method for diagnosis of COVID-19 based on its features and transformation rule, before initial RT-PCR screening.

scholarly journals Evaluation of rapid antibody test and chest computed tomography results of COVID-19 patients: A retrospective study

2021 ◽  
Author(s):  
Ali Ozturk ◽  
Taylan Bozok ◽  
Tugce Simsek Bozok
Keyword(s):  
Computed Tomography ◽  
Ct Scan ◽  
Antibody Test ◽  
Chest Ct ◽  
Rt Pcr ◽  
Serum Samples ◽  
Chest Computed Tomography ◽  
Ct Data ◽  
Chest Ct Scan ◽  
Rapid Antibody

AbstractBackgroundThe coronavirus disease 2019 (COVID-19) continues to spread around the world. Therefore, rapid, simpler, and more accurate diagnostic tests are urgently needed to diagnose the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. The purpose of this study was to evaluate the SARS-CoV-2 IgM/ IgG rapid antibody test results in symptomatic patients with COVID-19 and their chest computed tomography (CT) data.MethodsA total of 320 patients admitted to our hospital for different durations due to COVID-19 were included in the study. Serum samples were obtained within 0 to 7 days from COVID-19 patients confirmed by RT-PCR and chest CT scan. According to the SARS-CoV-2 RT-PCR results, the patients included in the study were divided into two groups: PCR positive group (n=46), and PCR negative group (n=274).ResultsOf the 320 COVID-19 serum samples, IgM, IgG, and IgM/IgG were detected in 9.4%, 3.1%, and 17.8% within one week respectively. IgG/IgM antibodies were not detected in 69.7% of the patients. In the study, it was determined that 249 (77.8%) of 320 patients had positive chest CT scans. Four (5.6%) of 100 patients with negative chest CT scan had IgM positive and 2 (2.8%) had both IgM/ IgG positive. IgM was detected in 23 (9.2%), IgG in 1 (0.4%) and IgM/IgG in 35 (14%) of chest CT scan positive patients. The rate of CT findings in patients with antibody positivity (n=97) was found to be significantly higher than those with antibody negativity.ConclusionsThe results of the present study show the accurate and equivalent performance of serological antibody assays and chest CT in detecting SARS-CoV-2 0 to 7 days from the onset of COVID19 symptoms. When the RT-PCR is not available, we believe that the combination of immunochromatographic test and chest CT scan can increase diagnostic sensitivity for COVID-19.

scholarly journals Gambaran Hasil CT-Scan Toraks pada Pasien Coronavirus Disease 2019 (COVID-19)

e-CliniC ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Claudia R. E. Malaru ◽  
Alfa G. E. Y. Rondo ◽  
Christilia G. Wagiu
Keyword(s):  
Computed Tomography ◽  
Severe Acute Respiratory Syndrome ◽  
Literature Review ◽  
Ct Scan ◽  
Chest Ct ◽  
Ground Glass ◽  
Computed Tomography Scan ◽  
First Case ◽  
Tomography Scan ◽  
Chest Ct Scan

Abstract: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Indonesia reported its first case in March 2, 2020. Cases are increasing and spreading rapidly throughout Indonesia. One of the main imaging modalities for examination of COVID-19 is chest computed tomography scan (CT-scan) which plays an important role in detection, evaluation of severity, and follow-up of disease course. This study was aimed to obtain the description of CT scan results in patients with COVID-19. This was a literature review study using three databases, namely Pubmed, ClinicalKey, and ScienceDirect. The keywords used were COVID-19 AND Chest CT. Based on inclusion and exclusion criteria, there were 10 literatures selected. It was found that chest CT results could accurately evaluate the features and extent of lung lesions. The typical CT-scan results were ground-glass opacities (GGO), GGO with mixed consolidation, adjacent pleural thickening, interlobular septal thickening, and air bronchogram. Based on age, sex, and comorbidities, there was not any significant differences in chest CT findings. In conclusion, GGO, air bronchogram, and consolidation were found in chest CT-scan of COVID-19 patients. Meanwhile, based on age, sex, and comorbidities there were no significant differences in chest CT-scan.Keywords: COVID-19, chest CT-scan Abstrak: Coronavirus disease 2019 (COVID-19) merupakan suatu penyakit menular yang disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Indonesia melaporkan kasus pertama pada tanggal 2 Maret 2020. Kasus meningkat dan menyebar dengan cepat di seluruh wilayah Indonesia. Salah satu modalitas pencitraan utama yang menjadi pilihan untuk pemeriksaan COVID-19 ialah Computed Tomography Scan (CT-scan) toraks yang berperan penting dalam deteksi, evaluasi keparahan, dan tindak lanjut perjalanan penyakit. Penelitian ini bertujuan untuk mengetahui gambaran hasil CT-scan pada pasien COVID-19. Jenis penelitian ialah literature review dengan pencarian data menggunakan tiga database yaitu Pubmed, ClinicalKey, ScienceDirect. Kata kunci yang digunakan yaitu COVID-19 AND Chest CT. Hasil seleksi berdasarkan kriteria inklusi dan eksklusi mendapatkan 10 literatur. Didapatkan hasil CT-scan toraks dapat secara akurat mengevaluasi fitur dan luas lesi paru dan CT-scan yang khas ialah ground-glass opacities (GGO), GGO dengan konsolidasi campuran, penebalan pleura yang berdekatan, penebalan septum interlobular, dan bronkogram udara. Pada temuan CT-scan toraks berdasarkan usia, dan jenis kelamin tidak didapatkan perbedaan bermakna. Simpulan penelitian ini ialah terdapat GGO, air bronchogram, dan konsolidasi pada CT-scan toraks pasien COVID-19 sedangkan berdasarkan usia, jenis kelamin, dan komorbid tidak ditemukan perbedaan bermakna.Kata kunci: COVID-19, CT-scan toraks

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