scholarly journals Amiodarone-induced pulmonary toxicity

2011 ◽  
Vol 1 (1) ◽  
pp. 6
Author(s):  
Junichi Ochi ◽  
Minoru Ohkouchi ◽  
Yoshikazu Tsukada ◽  
Shinichiro Tominaga ◽  
Satoshi Takayama ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Medical Records ◽  
Lung Biopsy ◽  
Pulmonary Toxicity ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Chest Computed Tomography ◽  
Ct Findings ◽  
The Mean ◽  
Foamy Macrophages

Amiodarone-induced pulmonary toxicity is a critical and potentially fatal side effect of amiodarone. Our study was designed to reveal its clinical features, including KL-6, as an interstitial marker. The medical records of eight patients (five men and three women) with amiodarone-induced pulmonary toxicity, who had been referred to our hospital, were examined. The mean age at the initiation of amiodarone was 48 years (range, 54-87 years) and mean duration of medication prior to the development of pulmonary toxicity was 18 months (range, 7-33 months). Serum KL-6 was elevated in six of the eight patients with a range of 525-2915 U/mL. Chest computed tomography (CT) findings showed non-segmental consolidation and/or ground glass opacity. Foamy macrophages were found in bronchoalveolar lavage (BAL) fluids of all examined patients and in transbronchial lung biopsy (TBLB) specimens in half of the examined patients. We concluded that serum KL-6, chest CT findings, and foamy macrophages in BAL fluids and TBLB specimens will be helpful for the diagnosis of amiodarone-induced pulmonary toxicity.

Chest Computed Tomography Findings in a Case Series of Coronavirus Disease 2019 (COVID-19) Patients at Siriraj Hospital

2021 ◽  
Vol 104 (5) ◽  
pp. 866-871
Keyword(s):  
Computed Tomography ◽  
Medical Records ◽  
Case Series ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Ground Glass ◽  
Chest Computed Tomography ◽  
Ct Findings ◽  
Siriraj Hospital ◽  
Chest Ct Scan

Background: Recent evidence has demonstrated the high sensitivity of chest computed tomography (CT) in coronavirus disease 2019 (COVID-19) case detection. However, considering the cost and infection control issues, the experience of chest CT for COVID-19 diagnosis in Thailand is still limited. Objective: To present the characteristics of chest CT findings in COVID-19 patients at Siriraj Hospital and compare them with other reports. Materials and Methods: The authors retrospectively reviewed the COVID-19 patients’ medical records between April and May 2020. All cases with the presence of chest CT performed during admission were recruited. Clinical data were retrieved from the patients’ medical records. All chest imaging results were reported by consensus between the authors. Results: From 103 cases, four cases with a chest CT scan during the admission were recruited. Consistent with previous reports, the common chest CT findings included a ground-glass opacity and consolidation with bilateral involvement. A round-shaped ground-glass opacity or consolidation was evidenced in half of the cases. The only case with the presence of chest CT scan, which was done 77 days after the onset of COVID-19 symptoms, revealed resolution of the abnormal findings. Conclusion: Chest CT findings in four COVID-19 cases at Siriraj Hospital are consistent with previous reports. Common findings include bilateral ground-glass opacity and consolidation. Keywords: COVID-19, SARS-CoV-2, Computed tomography, Case series

scholarly journals Clinical outcomes of hemodialysis patients infected with severe acute respiratory syndrome coronavirus 2 and impact of proactive chest computed tomography scans

2020 ◽  
Vol 13 (3) ◽  
pp. 328-333 ◽  
Author(s):  
Rui Wang ◽  
Hong He ◽  
Cong Liao ◽  
Hongtao Hu ◽  
Chun Hu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Invasive Mechanical Ventilation ◽  
Case Series ◽  
Ground Glass Opacity ◽  
High Sensitivity ◽  
Chest Ct ◽  
Maintenance Hemodialysis ◽  
Rt Pcr ◽  
Chest Computed Tomography ◽  
Reactive Protein

Abstract Background Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that first manifested in humans in Wuhan, Hubei Province, China, in December 2019, and has subsequently spread worldwide. Methods We conducted a retrospective, single-center case series of the seven maintenance hemodialysis (HD) patients infected with COVID-19 at Zhongnan Hospital of Wuhan University from 13 January to 7 April 2020 and a proactive search of potential cases by chest computed tomography (CT) scans. Results Of 202 HD patients, 7 (3.5%) were diagnosed with COVID-19. Five were diagnosed by reverse transcription polymerase chain reaction (RT-PCR) because of compatible symptoms, while two were diagnosed by RT-PCR as a result of screening 197 HD patients without respiratory symptoms by chest CT. Thirteen of 197 patients had positive chest CT features and, of these, 2 (15%) were confirmed to have COVID-19. In COVID-19 patients, the most common features at admission were fatigue, fever and diarrhea [5/7 (71%) had all these]. Common laboratory features included lymphocytopenia [6/7 (86%)], elevated lactate dehydrogenase [3/4 (75%)], D-dimer [5/6 (83%)], high-sensitivity C-reactive protein [4/4 (100%)] and procalcitonin [5/5 (100%)]. Chest CT showed bilateral patchy shadows or ground-glass opacity in the lungs of all patients. Four of seven (57%) received oxygen therapy, one (14%) received noninvasive and invasive mechanical ventilation, five (71%) received antiviral and antibacterial drugs, three (43%) recieved glucocorticoid therapy and one (14%) received continuous renal replacement therapy. As the last follow-up, four of the seven patients (57%) had been discharged and three patients were dead. Conclusions Chest CT may identify COVID-19 patients without clear symptoms, but the specificity is low. The mortality of COVID-19 patients on HD was high.

scholarly journals Chest Computed Tomography Findings in Asymptomatic Patients with COVID-19

Respiration ◽  
2020 ◽  
Vol 99 (9) ◽  
pp. 748-754 ◽  
Author(s):  
Min Cheol Chang ◽  
Wonho Lee ◽  
Jian Hur ◽  
Donghwi Park
Keyword(s):  
Computed Tomography ◽  
South Korea ◽  
Respiratory System ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Effective Management ◽  
Radiographic Findings ◽  
Chest Computed Tomography ◽  
Asymptomatic Patients ◽  
The Right

<b><i>Background:</i></b> Little is known about the damage to the respiratory system in asymptomatic patients with coronavirus disease (COVID-19). <b><i>Objective:</i></b> Herein, we evaluate the findings of chest computed tomography (CT) and radiography in patients with COVID-19 who were asymptomatic. <b><i>Methods:</i></b> We retrospectively investigated patients with a confirmed diagnosis of COVID-19 but who did not show any symptoms. Among the 139 patients with COVID-19 who were hospitalized in Yeungnam University Hopistal in Daegu, South Korea, 10 (7.2%) were asymptomatic. Their chest CT and radiographic findings were analyzed. <b><i>Results:</i></b> In the results, all patients (100%) had ground-glass opacity (GGO) on chest CT. Further, the GGO lesions were predominantly distributed peripherally and posteriorly in all patients. In 9 (90%) patients, the GGO lesions were combined with reticular opacity. Air bronchogram due to bronchiolectasis surrounded by GGO was observed in 8 patients (80%). Additionally, the lung lesions were dominant on the right side in all patients. <b><i>Conclusions:</i></b> In conclusion, considering our results that the lung is affected in asymptomatic patients, it will be necessary to extend the indications of COVID-19 testing for effective management of COVID-19 during the pandemic.

scholarly journals COVID-19 pneumonia: The first two chest CTs in the Bamrasnaradura Infectious Disease Institute

2020 ◽  
pp. 69-81
Author(s):  
Panyaros Kongpanya ◽  
Parichut Vongthawatchai ◽  
Priyanut Atiburanakul ◽  
Nayot Panitanum ◽  
Patama Suttha
Keyword(s):  
Infectious Disease ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Lung Involvement ◽  
Chest Computed Tomography ◽  
Ct Findings ◽  
Infectious Disease Institute ◽  
The World ◽  
Bilateral Lung ◽  
Interlobular Septal Thickening

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread rapidly around the world. We reported the first two cases of COVID-19 pneumonia who had the chest computed tomography (CT) performed at the Bamrasnaradura Infectious Disease Institute (BIDI). The chest CT findings in the two patients with COVID-19 pneumonia showed bilateral lung involvement, multifocal involvement, peripheral distribution, ground glass opacity (GGO), consolidation and GGO with interlobular septal thickening (“crazy-paving” pattern). The chest CT findings in these patients are nonspecific and overlapped with other diseases.

scholarly journals Coronavirus disease 2019 (COVID-19) in Italy: features on chest computed tomography using a structured report system

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Grassi Roberto ◽  
Fusco Roberta ◽  
Belfiore Maria Paola ◽  
Montanelli Alessandro ◽  
Patelli Gianluigi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Ground Glass Opacity ◽  
Mean Value ◽  
Chest Ct ◽  
Viral Pneumonia ◽  
Mediastinal Lymphadenopathy ◽  
Rt Pcr ◽  
Chest Computed Tomography ◽  
Trunk Diameter ◽  
Structured Report

Abstract To assess the use of a structured report in the Chest Computed Tomography (CT) reporting of patients with suspicious viral pneumonia by COVID-19 and the evaluation of the main CT patterns. This study included 134 patients (43 women and 91 men; 68.8 years of mean age, range 29–93 years) with suspicious COVID-19 viral infection evaluated by reverse transcription real-time fluorescence polymerase chain reaction (RT-PCR) test. All patients underwent CT examinations at the time of admission. CT images were reviewed by two radiologists who identified COVID-19 CT patterns using a structured reports. Temporal difference mean value between RT-PCRs and CT scan was 0.18 days ± 2.0 days. CT findings were positive for viral pneumonia in 94.0% patients while COVID-19 was diagnosed at RT-PCR in 77.6% patients. Time mean value to complete the structured report by radiologist was 8.5 min ± 2.4 min. The disease on chest CT predominantly affected multiple lobes and the main CT feature was ground glass opacity (GGO) with or without consolidation (96.8%). GGO was predominantly bilateral (89.3%), peripheral (80.3%), multifocal/patching (70.5%). Consolidation disease was predominantly bilateral (83.9%) with prevalent peripheral (87.1%) and segmental (47.3%) distribution. Additional CT signs were the crazy-paving pattern in 75.4% of patients, the septal thickening in 37.3% of patients, the air bronchogram sign in 39.7% and the “reversed halo” sign in 23.8%. Less frequent characteristics at CT regard discrete pulmonary nodules, increased trunk diameter of the pulmonary artery, pleural effusion and pericardium effusion (7.9%, 6.3%, 14.3% and 16.7%, respectively). Barotrauma sign was absent in all the patients. High percentage (54.8%) of the patients had mediastinal lymphadenopathy. Using a Chest CT structured report, with a standardized language, we identified that the cardinal hallmarks of COVID-19 infection were bilateral, peripheral and multifocal/patching GGO and bilateral consolidation with peripheral and segmental distribution.

scholarly journals The Effect of Chest Computed Tomography Findings on QT Interval in Patients with COVID 19 Using Drugs That May Prolong QT Interval

2021 ◽  
Author(s):  
Ferhat Özyurtlu ◽  
Nurullah Cetin ◽  
Veysel Yavuz
Keyword(s):  
Computed Tomography ◽  
Heart Rate ◽  
Qt Interval ◽  
Chest Ct ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Chest Computed Tomography ◽  
Qt Interval Prolongation ◽  
Ct Findings ◽  
Low Sensitivity

Background Some drugs used in the treatment of coronavirus disease 2019 (COVID-19) are likely to increase the risk of QT interval prolongation and related arrhythmias or death. Due to the low sensitivity of the reverse transcriptase-polymerase chain reaction (RT-PCR) test, chest computed tomography (CT) imaging is being used for COVID-19 diagnostic correlation and to evaluate whether there is pneumonic involvement in the lung. Objective In this study, we aimed to compare whether there was a difference in terms of QT interval prolongation and effect on heart rate in COVID-19 patients based on their chest CT findings and drug treatment regimes. Methods This was a single-center retrospective cohort study of non-intensive care unit (ICU) patients hospitalized . A total of 344 patients with a mean age of 46.34 ± 17.68 years were included in the study (56.1% men). Patients were divided into four groups according to their chest CT results as having typical, atypical, indeterminate, or no finding of pneumonic involvement. Mean QTc intervals and heart rates calculated from electrocardiograms at admission and after treatment were compared. Results There were no significant differences between groups with regards to age, gender, and body mass index (BMI). There were also no significant differences between the groups in terms of mean QTc interval values upon admission (p:0.127) or after treatment (p:0.205). Heart rate values were similar among the groups as well, with no significant differences in mean heart rate on admission (p:0.648) and post-treatment (p:0.229) ECGs. Conclusion This study has demonstrated finding of COVID-19 infection based on chest CT does not affect QT interval prolongation and bradycardia in non-ICU COVID-19 patients. There is a need for additional larger studies investigating the effect of chest CT findings on QT interval prolongation and bradycardia in COVID-19 patients.

scholarly journals Invasive candidiasis presenting multiple pulmonary cavitary lesions on chest computed tomography

2015 ◽  
Vol 10 ◽  
Author(s):  
Yuichiro Yasuda ◽  
Kazunori Tobino ◽  
Mina Asaji ◽  
Yoshikazu Yamaji ◽  
Kosuke Tsuruno
Keyword(s):  
Computed Tomography ◽  
Invasive Candidiasis ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Pulmonary Aspergillosis ◽  
Chest Computed Tomography ◽  
Remarkable Improvement ◽  
First Case ◽  
Ct Finding ◽  
Chest Ct Scan

We herein report a case of invasive candidiasis presenting rare findings on chest computed tomography (CT). The chest CT scan showed multiple small cavitary lesions and nodules with surrounding ground-glass opacity, and also bilateral pleural effusion. Although this CT finding is thought as specific for pulmonary aspergillosis, two sets of blood culture specimens were drawn which yielded Candida albicans  in our case. Antifungal therapy was started and the chest CT findings showed a remarkable improvement. To our knowledge, this is the first case report describing multiple pulmonary cavitary lesions in invasive candidiasis.

Comparisons of chest computed tomography patterns between survivors and non-survivors with Coronavirus Disease 2019 (COVID-19): a case-control study

2020 ◽  
Author(s):  
Feng Pan ◽  
Chuansheng Zheng ◽  
Tianhe Ye ◽  
Lingli Li ◽  
Dehan Liu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Control Study ◽  
Case Control ◽  
Chest Ct ◽  
Curve Estimation ◽  
Chest Computed Tomography ◽  
Male Ratio ◽  
Survivor Group ◽  
Ct Findings ◽  
Control Study

Abstract Objectives To compare the chest computed tomography (CT) findings between survivors and non-survivors with Coronavirus Disease 2019 (COVID-19).Materials and Methods Between 12 January 2020 to 20 February 2020, the records of 124 consecutive patients diagnosed with COVID-19 were retrospectively reviewed and divided into survivor (83/124) and non-survivor (41/124) groups. Chest CT findings were qualitatively compared on admission and serial chest CT scans were semi-quantitively evaluated between two groups using curve estimations.Results Elder age (median: 69 vs. 43y, p<0.001), higher male ratio (31/41 vs. 32/83, p<0.001), and more comorbidities were observed in non-survivor group. On admission, significantly more bilateral (97.6% vs. 73.5%, p=0.005) and diffuse lesions (39.0% vs. 8.4%, p<0.001) with higher total CT score (median: 10 vs. 4) were observed in non-survivor group compared with survivor group. Besides, crazy-paving pattern was more predominant in non- survivor group than survivor group (39.0% vs. 12.0%, p=0.004). From the prediction of curve estimation, in survivor group total CT score increased in the first 20 days reaching the peak of 6 points and then gradual decreased for more than other 40 days (R2=0.545, p<0.001). In non- survivor group, total CT score rapidly increased over 10 points in the first 10 days and gradually increased afterwards until ARDS occurred with following death events (R2=0.711, p<0.001).Conclusions Persistent progression with predominant crazy-paving pattern was the major manifestation of COVID-19 in non-survivors. Understanding this CT feature could help the clinical physician to predict the prognosis of the patients.

scholarly journals Feasibility of Coronary Artery Calcium Scoring on Dual-Energy Chest Computed Tomography: A Prospective Comparison with Electrocardiogram-Gated Calcium Score Computed Tomography

2021 ◽  
Vol 10 (4) ◽  
pp. 653
Author(s):  
Sun Yong Lee ◽  
Tae Hoon Kim ◽  
Kyunghwa Han ◽  
Jae Min Shin ◽  
Ji Young Kim ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Calcium Score ◽  
Dual Energy ◽  
Chest Ct ◽  
Slice Thickness ◽  
Calcium Scoring ◽  
Chest Computed Tomography ◽  
Contrast Enhanced ◽  
Virtual Unenhanced ◽  
The Mean

Rationale and Objectives: This study aimed to evaluate the feasibility of assessment using the coronary artery calcium score (CACS) in dual-energy chest computed tomography (CT). Materials and Methods: We prospectively enrolled 30 patients (19 male, 11 female; mean age, 63.73 ± 9.40 years) who clinically required contrast-enhanced chest CT. The patients underwent electrocardiogram-gated cardiac calcium-scoring CT with a slice thickness of 2.5 mm followed by a sequentially non-gated contrast-enhanced dual-energy chest CT using 140/80 fast kVp switching technology with slice thicknesses of 1.25 mm and 2.5 mm. Virtual unenhanced (VUE) images were then reconstructed from the dual-energy CT using the material suppressed iodine (MSI) technique. Results: The mean heart rates were 63.33 ± 12.01 beats per minute. The mean CACS on the coronary calcium-scoring CT was 361.1 ± 435.5, and CACSs of the VUE images were 76.8 ± 128.6 (2.5 mm slice) and 108.7 ± 165.1 (1.25 mm slice). The correlation coefficients of CACS between the coronary calcium-scoring CT with the VUE 2.5 mm and 1.25 mm images were 0.888 and 0.904, respectively. The inter-observer agreements for the calcium score measurement between the calcium-scoring CT, VUE 2.5 mm, and VUE 1.25 mm were 1.000, 0.999, and 1.000, respectively. Conclusions: In conclusion, assessment of CACS using dual-energy chest CT might be feasible when using MSI virtual unenhanced dual-energy chest CT images with a slice thickness of 1.25 mm.

scholarly journals Chest computed tomography and chest X-ray in the diagnosis of community-acquired pneumonia: a retrospective observational study

2021 ◽  
Vol 49 (8) ◽  
pp. 030006052110397
Author(s):  
Dima Ibrahim ◽  
Abdul Rahman Bizri ◽  
Mohammad Ali El Amine ◽  
Zeina Halabi
Keyword(s):  
Computed Tomography ◽  
Medical Records ◽  
Community Acquired Pneumonia ◽  
Chest Ct ◽  
Chest Computed Tomography ◽  
X Ray ◽  
Combined Use ◽  
Chest X Ray ◽  
Large Benefit ◽  
The Impact

Objectives To compare the yield of early combined use of chest X-ray (CXR) and chest computed tomography (CT) in patients diagnosed with community-acquired pneumonia (CAP) presenting to the emergency department (ED) and assess the impact of chest CT on the initial diagnosis. Methods The medical records of 900 patients who presented to the ED and were diagnosed with CAP over a 1-year period were reviewed, and 130 patients who underwent CXR and chest CT within 48 hours were selected. CXR findings were classified as positive, negative, or inconclusive for CAP. Chest CT findings were defined as positive, negative, inconclusive, or positive with add-on to the CXR findings. CT was classified as having no benefit, large benefit, or moderate benefit based on the chest CT and CXR findings. Results Chest CT results were positive in 90.7% of patients, with 41.5% being newly diagnosed after negative or inconclusive CXR and 21.5% being diagnosed with add-on to the CXR findings. CT had large, moderate, and no benefit over CXR in diagnosing or excluding CAP in 45.3%, 21.5%, and 33.1% of patients, respectively. Conclusion Early chest CT may be used to compliment CXR in the early diagnosis of CAP among patients in the ED.

Sign in / Sign up

Export Citation Format

Share Document