scholarly journals Pleural mesothelioma in Poland: Spatial analysis of malignant mesothelioma prevalence in the period 1999-2013

2018 ◽  
Vol 13 (2) ◽  
Author(s):  
Małgorzata Krówczyńska ◽  
Ewa Wilk ◽  
Piotr Pabjanek ◽  
Gabriela Olędzka
Keyword(s):  
Malignant Mesothelioma ◽  
Spatial Clustering ◽  
Asbestos Exposure ◽  
Incidence Rates ◽  
Autocorrelation Analysis ◽  
Manufacturing Plants ◽  
Southern Poland ◽  
Asbestos Cement ◽  
High Incidence ◽  
Administrative Units

Malignant mesothelioma (MM), a rare and very deadly tumour, can be due to asbestos exposure. To better understand the cause of incidence of MM, spatial autocorrelation analysis with reference to the quantity of asbestos-cement products in use and the localisation of former asbestos manufacturing plants was applied. Geostatistical analysis shows that strong spatial clustering of MM incidence (referring to the general population as well as females and males separately) during the period 1999-2013 in the administrative units of Poland (provinces and counties). Incidence hotspots were found to be concentrated primarily in southern Poland but also seen in the county of Szczecin, which stands out in local autocorrelation analysis in north-western Poland. High incidence rates were discovered, in particular with reference to counties around former plants manufacturing asbestos-containing products, mainly asbestos-cement manufacturers. The highest frequency of MM incidence rate was found in within a 55 km radius of plants in or near the towns Trzebinia, Ogrodzieniec and Szczucin in the South, where asbestos-cement products had been manufactured for close to 40 years. Areas with significantly high incidence rates were also discovered in the provinces of Śląskie, Małopolskie and Świętokrzyskie in southern Poland.

scholarly journals Asbestos Exposure and the Mesothelioma Incidence in Poland

2018 ◽  
Vol 15 (8) ◽  
pp. 1741 ◽  
Author(s):  
Małgorzata Krówczyńska ◽  
Ewa Wilk
Keyword(s):  
Asbestos Exposure ◽  
Morbidity Rate ◽  
Eastern European ◽  
Manufacturing Plants ◽  
Asbestos Cement ◽  
The Social ◽  
Wide Range ◽  
Random Forest Models ◽  
Administrative Units ◽  
Eastern European Countries

Asbestos is carcinogenic to humans; the exposure to asbestos causes a wide range of diseases. Aim: Malignant mesothelioma (MM) is unique for asbestos exposure. Methods: Based on the physical inventory of asbestos-cement roofing, the social-economic situation of communes, the proximity of asbestos manufacturing plants, the land use data referring to the surface of the built-up area, and the historical data on the annexations, the amount of asbestos-containing products in use was estimated by computing best Random Forest models. Per capita asbestos use is an indicator to compare the state of asbestos use among countries. MM cases in the local administrative units (provinces) were tested by the application of Moran’s I and Getis and Ord statistic. Results: The total amount of asbestos roofing in Poland was estimated at 738,068,000 m2 (8.2 million tons). In total there were 28 plants in Poland located in 11 provinces throughout the country. The amount of asbestos-cement roofing in use is correlated primarily with the measurements of asbestos concentration fibers (rs = 0.597). MM raw morbidity rate was calculated, stratified by province, and classified into five groups with respect to incidence. Hotspots of MM cases are in the southern part of Poland. Conclusions: MM cases are concentrated in the same geographical areas, which may indicate an increasing impact of environmental exposure. The results of the local and global autocorrelation clearly indicate a statistically significant relationship between incidences of MM in provinces. Poland and other Eastern European countries are among countries with low MM incidence rate. Detailed investigation is desirable since the current MM morbidity rate in Poland seems to be underestimated.

Malignant mesothelioma in 91 danish women: The environmental asbestos exposure.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 8560-8560 ◽  
Author(s):  
Vasiliki Panou ◽  
Mogens Vyberg ◽  
Christos Meristoudis ◽  
Øyvind Omland ◽  
Ulla Møller Weinreich ◽  
...  
Keyword(s):  
Risk Factor ◽  
Environmental Exposure ◽  
Malignant Mesothelioma ◽  
Patient Information ◽  
Medical Records ◽  
Asbestos Exposure ◽  
University Hospital ◽  
Populated Area ◽  
Asbestos Worker ◽  
Asbestos Cement

8560 Background: Malignant Mesothelioma (MM) is an asbestos-related malignancy that presents mainly in the pleura (MPM) and peritoneum (MAM). In a densely populated area of Aalborg city in North Jutland, Denmark, a large Eternit asbestos factory that was active for 60 years until 1986 and two shipyards were situated. The Region of North Jutland, Denmark has a high mm incidence in women of 1.0/100,000. Methods: From 1974-2015, 101 histological and cytological samples of women diagnosed with mm in Aalborg University Hospital were identified re-evaluated by modern immunohistochemistry. Patient information regarding asbestos exposure was retrieved from medical records and selected Danish registries. Asbestos exposure was classified as primary for asbestos workers; domestic, for women living with an asbestos worker; environmental, when living or working within 10.000 meters from an asbestos emitting location; unknown, where no source of asbestos exposure could be identified. Results: Clinical and histopathological mm diagnosis was certain for 91 women. Potential asbestos exposure is summarized in Table 1. The employment of the women and their relatives include work at the asbestos cement factory, shipyard, construction, laboratory, pipe factory, electrician and insulator. The women with domestic and combined domestic and environmental (secondary) exposure to asbestos were most prone to develop MPM rather than MAM while women primary exposed to asbestos developed MAM rather than MPM (p=0.016). Conclusions: This study showed that the vast majority (64%) of the women diagnosed with mm had documented non-occupational asbestos exposure and almost 1/5 had a sole environmental exposure, by living in proximity to asbestos industry. Environmental asbestos exposure is a serious risk factor for mm in women. Primary asbestos exposure, inferring more intense exposure through occupation, may predispose to peritoneal mesothelioma in women. [Table: see text]

Malignant Mesothelioma in Rome, Italy 1980-1995. A Retrospective Study of 79 Patients

1996 ◽  
Vol 82 (6) ◽  
pp. 526-532 ◽  
Author(s):  
Valeria Ascoli ◽  
Caterina Carnovale Scalzo ◽  
Francesco Facciolo ◽  
Massimo Martelli ◽  
Liborio Manente ◽  
...  
Keyword(s):  
Construction Industry ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Case Series ◽  
Indoor Exposure ◽  
Railroad Workers ◽  
Asbestos Cement ◽  
Job Titles ◽  
Clinical Records ◽  
Navy Personnel

Aim and background To evaluate the characteristics of a case-series of 79 malignant mesothelioma patients collected from the main teaching hospital of Rome, Italy, and other local clinics of Latium Region and to assess the role of asbestos exposure, since previous studies on the occurrence of the disease in this area were lacking. Methods The study included cytohistologically diagnosed malignant mesothelioma (71 pleural, 7 peritoneal, and 1 testicular tunica vaginalis) detected or referred for consultation during the period 1980-1995. Information regarding occupational and/or nonoccupational exposures was derived from clinical records and interviews, when available. Results Patients were resident in Rome and other towns of Latium; a few were from other parts of central and southern Italy. Exposure to asbestos was assessed for 45.5% of patients, another 45.5% had unknown exposure, and for the remaining 9% such information was lacking. Occupational exposure occurred in 53% of men for whom information was available and nonoccupational exposure occurred in 20% of women. The study identified two clusters of cases from an asbestos-cement plant and a facility where asbestos was ubiquitous. Furthermore, most exposed subjects reported occupations in the construction industry, which is particularly active in the Latium Region; others were railroad workers, naval mechanics and navy personnel, bakers, explosive workers and car mechanics. A few patients reported indoor exposure to asbestos at home and/or in the workplace. Conclusions The study confirmed that mesothelioma risk is present in several job titles of the construction industry, and it is no longer confined to workers employed in the manufacture or application of asbestos products. The occurrence of malignant mesothelioma in patients with unexpected occupational and nonoccupational exposures indicates the need for further investigation on previously underestimated exposures.

Malignant mesotheliomas in residents in the National Priority Contaminated Sites in Tuscany

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
E Chellini ◽  
A Martini
Keyword(s):  
Malignant Mesothelioma ◽  
Environmental Remediation ◽  
Asbestos Exposure ◽  
Incidence Rates ◽  
Contaminated Sites ◽  
Incidence Data ◽  
National Priority ◽  
Standard Population ◽  
Sentinel Event ◽  
And Gender

Abstract Background Asbestos is a well-known carcinogen. A law banning asbestos is active in Italy since 1992. A surveillance system on malignant mesothelioma is ongoing in Tuscany since 1988. The aim is to describe mesothelioma incidence in the specific regional areas defined as National Priority Contaminated Sites in order to have suggestions on specific environmental remediation activities focused on asbestos. Methods Malignant mesotheliomas diagnosed in residents during 1988-2019 in the above cited areas are extracted from the specific regional registry. Standardized incidence rates are calculated by area and gender using 2013 European as standard population. Standardized incidence ratios are also calculated by area in the whole period, using the regional rates as reference. The distribution of cases by exposure and areas are analyzed. Results In the examined areas 510 cases are registered (423 in men and 87 in women). Male incidence rates are 10.0 (IC90% 8.4-11.6), 5.8 (IC90%3.2-8.3), 5.5 (IC90% 4.1-6.9) and 1.7 (IC90% 0.0-3.9) respectively in Livorno, Piombino, Massa and Orbetello. Female incidence rates are far below than those observed for men. The highest standardized incidence ratio is observed in Livorno (3.1, IC90% 2.6-3.6). The vast majority of cases (no.393) are related to occupational asbestos exposure, mainly occurred in the same residence area. Asbestos familial and environmental exposure was attributed respectively to 22 and 4 cases. Conclusions The availability of a long series of incidence data on malignant mesotheliomas allowed to evaluate the asbestos impact among residents in Tuscan contaminated areas. The results obtained show the great importance of past occupational asbestos exposure. Key messages Malignant mesothelioma is a sentinel event of past asbestos exposure. The mesothelioma burden in the contaminated area is helpful to prioritise specific environmental remediation activities.

scholarly journals Spatial analysis of asbestos exposure and occupational health care in Poland during the period 2004-2013

2018 ◽  
Vol 13 (2) ◽  
Author(s):  
Małgorzata Krówczyńska ◽  
Ewa Wilk
Keyword(s):  
Spatial Analysis ◽  
Asbestos Exposure ◽  
Occupational Health Care ◽  
Asbestos Fibre ◽  
National Programme ◽  
Manufacturing Plants ◽  
Current State ◽  
Asbestos Cement ◽  
Wide Range ◽  
Asbestos Abatement

Asbestos is carcinogenic to humans and exposure to this substance can cause a wide range of diseases. In Poland 1997, a statutory ban was introduced on the production, use and marketing of products containing asbestos. The National Programme for Asbestos Abatement for 2009-2032 includes scheduled activities considering asbestos exposure assessment and health protection. As there are several data sources for asbestos exposure in Poland, which are not linked, the aim of this study was to gather and order them developing a PostgreSQL database, an open-source, objectrelational system. The data gathered combines the following information: the quantity of asbestos-cement products in use, details of asbestos manufacturing plants, the results of the measurements of asbestos fibre concentrations in the air and cases of asbestos-related diseases. The relational database was then used to develop a spatial analysis of asbestos monitoring and exposure in Poland to demonstrate the current state of realisation of the National Asbestos Abatement Programme in the country for 2009-2032 with the use of geoinformation techniques. The use of a database on health aspects of occupational and environmental asbestos exposure was also proposed in Asbestos, Asbestosis, and Cancer: Helsinki Criteria update 2014.

scholarly journals Asbestos Exposure Level and the Carcinogenic Risk Due to Corrugated Asbestos-Cement Slate Roofs in Korea

2021 ◽  
Vol 18 (13) ◽  
pp. 6925
Author(s):  
Eun-Soo Lee ◽  
Young-Ki Kim
Keyword(s):  
Asbestos Exposure ◽  
Health Impact ◽  
Pooled Analysis ◽  
Carcinogenic Risk ◽  
University Hospital ◽  
Exposure Level ◽  
Lifetime Cancer Risk ◽  
Indoor Exposure ◽  
Asbestos Cement ◽  
Environmental Causes

Asbestos-cement slate roofs are one of the most common environmental causes of asbestos exposure. However, few studies have examined residential asbestos-cement slate-related exposure and its effects on human health. This study was performed to evaluate cumulative asbestos exposure levels and to calculate the Excess Lifetime Cancer Risk (ELCR) of residents of asbestos-cement slate-roofed houses. We reviewed previous Korean literature to estimate the concentration of airborne asbestos from asbestos-cement slate roofed buildings. Finally, eight studies were selected, and a pooled analysis was performed. The results derived from the pooled analysis were combined with the data from a health impact survey conducted from 2009 to 2016 at the Environmental Health Center for Asbestos (EHCA) of the Yangsan Pusan National University Hospital, and a carcinogenic risk assessment was performed. As a result, the representative value of the indoor exposure concentration related to asbestos-cement slate was found to be 0.0032 f/cc on average, and the representative value of the exposure related to occupational asbestos-cement slate dismantling and demolition was found to be 0.0034 f/cc. In addition, the ELCR of asbestos-cement slate related indoor exposure and occupational dismantling and demolition was found to be of medium risk, and the ELCR of residential dismantling and demolition of asbestos-cement slate was less than 10−6, indicating that the risk was low. Since there is no threshold for carcinogenicity related to asbestos, this should not be ignored even if the risk appears low, and it would be reasonable to calculate the carcinogenic risk based on total lifetime exposure. More studies on asbestos exposure scenarios and the scope of similar exposure groups through additional data collection and further analysis of risk are needed.

scholarly journals Temporal and geographic analysis of trichinellosis incidence in Chile with risk assessment

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Carlos Landaeta-Aqueveque ◽  
Salvador Ayala ◽  
Denis Poblete-Toledo ◽  
Mauricio Canals
Keyword(s):  
Relative Risk ◽  
Poverty Rate ◽  
Incidence Rates ◽  
Temporal Data ◽  
Rate Fluctuation ◽  
High Incidence ◽  
Domestic Cycle ◽  
Model Residuals ◽  
Free Ranging ◽  
Spearman’S Correlation

AbstractTrichinellosis is a foodborne disease caused by several Trichinella species around the world. In Chile, the domestic cycle was fairly well-studied in previous decades, but has been neglected in recent years. The aims of this study were to analyze, geographically, the incidence of trichinellosis in Chile to assess the relative risk and to analyze the incidence rate fluctuation in the last decades. Using temporal data spanning 1964–2019, as well as geographical data from 2010 to 2019, the time series of cases was analyzed with ARIMA models to explore trends and periodicity. The Dickey-Fuller test was used to study trends, and the Portmanteau test was used to study white noise in the model residuals. The Besag-York-Mollie (BYM) model was used to create Bayesian maps of the level of risk relative to that expected by the overall population. The association of the relative risk with the number of farmed swine was assessed with Spearman’s correlation. The number of annual cases varied between 5 and 220 (mean: 65.13); the annual rate of reported cases varied between 0.03 and 1.9 cases per 105 inhabitants (mean: 0.53). The cases of trichinellosis in Chile showed a downward trend that has become more evident since the 1980s. No periodicities were detected via the autocorrelation function. Communes (the smallest geographical administrative subdivision) with high incidence rates and high relative risk were mostly observed in the Araucanía region. The relative risk of the commune was significantly associated with the number of farmed pigs and boar (Sus scrofa Linnaeus, 1758). The results allowed us to state that trichinellosis is not a (re)emerging disease in Chile, but the severe economic poverty rate of the Mapuche Indigenous peoples and the high number of backyard and free-ranging pigs seem to be associated with the high risk of trichinellosis in the Araucanía region.

scholarly journals Application of an Innovative Model for the Risk Management of COVID-19 in a Multinational Manufacturing Company

2021 ◽  
Vol 13 (11) ◽  
pp. 5771
Author(s):  
Piero Lovreglio ◽  
Angela Stufano ◽  
Francesco Cagnazzo ◽  
Nicola Bartolomeo ◽  
Ivo Iavicoli
Keyword(s):  
Risk Management ◽  
Manufacturing Industry ◽  
Incidence Rates ◽  
Manufacturing Plants ◽  
Model Combining ◽  
Innovative Model ◽  
Global Prevention ◽  
The Relationship ◽  
Physician Team ◽  
The Eu

The COVID-19 incidence in 61 manufacturing plants in Europe (EU), North America (NA) and Latin-America (LATAM) was compared with the incidence observed in the countries where the plants are located in order to evaluate the application of an innovative model for COVID-19 risk management. Firstly, a network of local and global teams was created, including an external university occupational physician team for scientific support. In July 2020, global prevention guidelines for the homogenous management of the pandemic were applied, replacing different site or regional procedures. A tool for COVID-19 monitoring was implemented to investigate the relationship between the incidence rates inside and outside the plants. In the period of May–November 2020, 565 confirmed cases (EU 330, NA 141, LATAM 94) were observed among 20,646 workers with different jobs and tasks, and in the last two months 85% EU and 70% NA cases were recorded. Only in 10% of cases was a possible internal origin of the contagion not excluded. In the EU and NA, unlike LATAM, the COVID-19 incidence rates inside the sites punctually followed the rising trend outside. In conclusion, the model, combining a global approach with the local application of the measures, maintains the sustainability in the manufacturing industry.

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