scholarly journals Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat

2009 ◽  
Vol 53 (4) ◽  
Author(s):  
C. Squillacioti ◽  
A. De Luca ◽  
S. Paino ◽  
E. Langella ◽  
N. Mirabella
Keyword(s):  
Medicine ◽  
2019 ◽  
Vol 98 (11) ◽  
pp. e14843 ◽  
Author(s):  
Jigang Jing ◽  
Hua Zhuang ◽  
Yan Luo ◽  
Huijiao Chen ◽  
Yaping Rao
Keyword(s):  

Author(s):  
P.E. Gibbs

Laboratory breeding of the dog-whelk, Nucella lapillus, has established that the male-sterilizing Dumpton Syndrome (DS)—underdevelopment, or non-development (aphally), of the penis, incomplete formation (non-closure) of the vas deferens, resulting in a split prostate—can be readily observed in male F1 progeny. Cultivated under high ambient concentrations of the antifouling agent tributyltin (TBT), DS-carrying females can be recognized by their lesser degree of masculinization (imposex): sterilization is thereby avoided. When Dumpton females are crossed, under high ambient TBT, with individuals from a non-DS-affected population (Bude, North Cornwall) DS is absent from both sexes. Crosses of these F1 progeny result in F2 progeny exhibiting the classic DS symptoms in both sexes. A Mendelian mechanism for DS inheritance is suggested by the data.


2003 ◽  
Vol 59 (9) ◽  
pp. 1999-2016 ◽  
Author(s):  
Nicola Mirabella ◽  
Caterina Squillacioti ◽  
Ettore Varricchio ◽  
Angelo Genovese ◽  
Giuseppe Paino

Author(s):  
P. E. Gibbs

Tributyltin (TBT) pollution has exterminated populations of the dog-whelk Nucella lapillus along most of the north Kent coast (Thames Estuary) but the species survives as a small enclave around the North Foreland. Males in this enclave exhibit an unusual defect involving the non-development or partial development of the genital system: about 10% lack penes, or have undersized penes, and their gonoducts (vas deferens and prostate) are incompletely developed; in some cases, spermatogenesis appears to be retarded. Laboratory-bred animals display the same characters. This deficiency (‘Dumpton Syndrome’) is manifest also in the atypical development of male sex organs on the females (‘imposex’) induced by exposure to tributyltin (TBT). The evidence points to Dumpton Syndrome being a genetic disorder which has lessened the sterilizing effect of imposex and thereby has permitted the survival of this isolated enclave in an area of high TBT pollution.


1970 ◽  
Vol 29 (1) ◽  
pp. 30-32
Author(s):  
RL Gurubacharya ◽  
SM Gurubacharya

The genitourinary tract is the most common extrapulmonary site affected by tuberculosis. The male genital organs are involved in more than 50% of patients. The epididymis is the commonest structure to be involved, followed by the seminal vesicles, prostate, testis, and the vas deferens. An isolated tuberculous orchitis without epididymal involvement is rare. This case report describes extra pulmonary tuberculosis with exclusively testicular presentation. The confirmatory diagnosis of which was made by FNAC of the testis. It provides a successful diagnosis, thereby preventing unnecessary orchidectomy. Key words: genitourinary tuberculosis, testis, USG, FNAC   doi:10.3126/jnps.v29i1.1598 J. Nepal Paediatr. Soc. Vol.29(1) p.30-32


2011 ◽  
Vol 60 (3) ◽  
pp. 307-316 ◽  
Author(s):  
Juan Pablo Mackern-Oberti ◽  
Mariana Maccioni ◽  
Maria Laura Breser ◽  
Adrian Eley ◽  
Thomas Miethke ◽  
...  

Chlamydia trachomatis is an intracellular pathogen that infects mucosal epithelial cells, causing persistent infections. Although chronic inflammation is a hallmark of chlamydial disease, the proinflammatory mechanisms involved are poorly understood. Little is known about how innate immunity in the male genital tract (MGT) responds to C. trachomatis. Toll-like receptors (TLRs) are a family of receptors of the innate immunity that recognize different pathogen-associated molecular patterns (PAMPs) present in bacteria, viruses, yeasts and parasites. The study of TLR expression in the MGT has been poorly investigated. The aim of this work was to investigate the keratinocyte-derived chemokine (KC) response of MGT primary cultures from C57BL/6 mice to C. trachomatis and different PAMPs. KC production by prostate, seminal vesicle and epididymis/vas deferens cell cultures was determined by ELISA in culture supernatants. TLR2, 3, 4 and 9 agonists induced the production of KC by all MGT primary cultures assayed. In addition, we analysed the host response against C. trachomatis and Chlamydia muridarum. Chlamydial LPS (cLPS) as well as C. trachomatis and C. muridarum infection induced KC secretion by all MGT cell cultures analysed. Differences in KC levels were observed between cultures, suggesting specific sensitivity against pathogens among MGT tissues. Chemokine secretion was observed after stimulation of seminal vesicle cells with TLR agonists, cLPS and C. trachomatis. To our knowledge, this is the first report showing KC production by seminal vesicle cells after stimulation with TLR ligands, C. trachomatis or C. muridarum antigens. These results indicate that different receptors of the innate immunity are present in the MGT. Understanding specific immune responses, both innate and adaptive, against chlamydial infections, mounted in each tissue of the MGT, will be crucial to design new therapeutic approaches where innate and/or adaptive immunity would be targeted.


1991 ◽  
Vol 98 (1) ◽  
pp. 85-89
Author(s):  
L. Coleman ◽  
A. Harris

The epithelia lining the vas deferens and epididymis are directly involved in the pathology of the autosomal recessive disease cystic fibrosis (CF). We have established culture systems for these epithelial cells. Long-term cell lines have now been generated from these primary epithelial cells by transformation with a plasmid containing an origin-defective simian virus 40 (SV40). Lines have been established from vas deferens and epididymis and both maintain expression of the CF gene.


2011 ◽  
Vol 71 (3) ◽  
pp. 747-754 ◽  
Author(s):  
A. Margraf ◽  
CLS. Costa-Ayub ◽  
MA. Okada ◽  
JR. Gomes ◽  
CF. Ortolani-Machado ◽  
...  

We examined the post-embryonic development of the male and female genital apparatus of the brown spider, Loxosceles intermedia. The development of the genital apparatus for both sexes begins with the appearance of inner structures. In the male genital apparatus, formation of the testes occurs first, followed by differentiation of the duct, ampulla and vas deferens, and finally the formation of the genital opening and differentiation of the copulatory organ (secondary sexual characteristic). Similarly, the development of the female genital apparatus begins with the formation of the ovaries, followed by the appearance of oocytes in vitellogenesis, then the development of oviducts and uterus internus and, finally, the spermatheca. These data may be very important in further comparative studies on the development of the reproductive system of spiders.


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