Fabrication of LTCC Micro-fluidic Devices For Wireless Lab-On-A-Chip Applications

2016 ◽  
Vol 2016 (CICMT) ◽  
pp. 000085-000088
Author(s):  
Achraf Ben Amar ◽  
Houssem Eddine Amor ◽  
Hung Cao ◽  
Ammar B. Kouki
Keyword(s):  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Dielectric Materials ◽  
Capacitance Measurement ◽  
Fluid Identification ◽  
Sensing Systems ◽  
Microfluidic Chamber ◽  
Micro Channels ◽  
Fluidic Devices ◽  
Electrical Permittivity

Abstract Low temperature co-fired ceramic (LTCC) based microfluidic sensors have been developed for biomedical and environmental sensing systems. This paper introduces a microfluidic chamber based on impedance spectroscopy measurements using LTCC technology for wireless Lab-On-A-Chip (LOC) applications. To overcome the channel sagging during the fabrication process, we used sacrificial carbon tapes as solid inserts, thus guiding the LTCC to follow their shape upon lamination and then formed micro-channels. The measurement chamber was a parallel-plate capacitive structure with 85 μm gap. This platform requires a small fluid sample of less than 4 μL. The sensor formed by the microfluidic channel and capacitance structure was characterized using different dielectric materials such as air, water and acetone. We hereby present the capability of LTCC-based systems in fluid identification by detecting their electrical permittivity using capacitance measurement.

scholarly journals Oxygen transport and release of adenosine triphosphate in micro-channels

2015 ◽  
Author(s):  
Terry Moschandreou
Keyword(s):  
Oxygen Transport ◽  
Rapid Change ◽  
Microfluidic Channel ◽  
Permeable Membrane ◽  
Micro Channels ◽  
Free Region ◽  
Method Of Solution ◽  
Channel Tube ◽  
A Cell ◽  
The Right

The governing nonlinear steady equations for oxygen transport in a microfluidic channel are solved analytically. The Lagrange inversion theorem is used which admits complete integrable solutions in the channel. Considering a cell-rich and cell free region with RBCs and blood plasma, we obtain results showing clearly that there is a significant decrease in oxygen tension in the vicinity of an oxygen permeable membrane placed on the upper channel/tube wall and to the right side of it in the downstream field. The purpose of the membrane is to cause a rapid change in oxygen saturation as RBC’s flow through channel/tube. To the right of the membrane downstream the greatest amount of ATP is released. The method of solution is compared to numerical results. The analytical results obtained could prove useful for the corresponding time dependent problem in future studies.

Low-Cost Microfluidic Channel Fabrication for Lab-on-a-Chip Application Using Optimized SU-8 Soft Lithography

2021 ◽  
Author(s):  
Md. Fazlay Rubby ◽  
Varsha Namboodiri ◽  
Mohammad Salman Parvez ◽  
Nazmul Islam
Keyword(s):  
Soft Lithography ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Lab On A Chip

Chapter 8. Novel Lab-on-a-Chip Sensing Systems: Applications of Optical, Electrochemical, and Piezoelectric Transduction in Bioanalysis

2014 ◽  
pp. 224-269
Author(s):  
Anthony J. Tavares ◽  
Samer Doughan ◽  
M. Omair Noor ◽  
Matthew V. DaCosta ◽  
Paul A. E. Piunno ◽  
...  
Keyword(s):  
Lab On A Chip ◽  
Sensing Systems ◽  
Piezoelectric Transduction

scholarly journals Optimization of selective laser-induced etching (SLE) for fabrication of 3D glass microfluidic device with multi-layer micro channels

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Sungil Kim ◽  
Jeongtae Kim ◽  
Yeun-Ho Joung ◽  
Sanghoon Ahn ◽  
Jiyeon Choi ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Microfluidic Channel ◽  
Design Guidelines ◽  
Process Window ◽  
Microfluidic Channels ◽  
Micro Channels ◽  
Scan Speed ◽  
Energy Pulse ◽  
Laser Induced Etching ◽  
Etching Selectivity

Abstract We present the selective laser-induced etching (SLE) process and design guidelines for the fabrication of three-dimensional (3D) microfluidic channels in a glass. The SLE process consisting of laser direct patterning and wet chemical etching uses different etch rates between the laser modified area and the unmodified area. The etch selectivity is an important factor for the processing speed and the fabrication resolution of the 3D structures. In order to obtain the maximum etching selectivity, we investigated the process window of the SLE process: the laser pulse energy, pulse repetition rate, and scan speed. When using potassium hydroxide (KOH) as a wet etchant, the maximum etch rate of the laser-modified glass was obtained to be 166 μm/h, exhibiting the highest selectivity about 333 respect to the pristine glass. Based on the optimized process window, a 3D microfluidic channel branching to three multilayered channels was successfully fabricated in a 4 mm-thick glass. In addition, appropriate design guidelines for preventing cracks in a glass and calibrating the position of the dimension of the hollow channels were studied.

Lab on a chip imaging and quantitative phase contrast in turbid microfluidic channel

2012 ◽  
Author(s):  
Melania Paturzo ◽  
Andrea Finizio ◽  
Pasquale Memmolo ◽  
Roberto Puglisi ◽  
Donatella Balduzzi ◽  
...  
Keyword(s):  
Phase Contrast ◽  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Quantitative Phase

Particle Manipulation Inside a Grooved Microfluidic Channel

2009 ◽  
Author(s):  
Hsiu-hung Chen ◽  
Dayong Gao
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Device ◽  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Cell Suspensions ◽  
Microfluidic Channels ◽  
Particle Manipulation ◽  
Post Processing ◽  
Processing Stage ◽  
Submicron Structures

The manipulation of particles and cells in micro-fluids, such as cell suspensions, is a fundamental task in Lab-on-a-Chip applications. According to their analysis purposes in either the pre- or post-processing stage, particles/cells flowing inside a microfluidic channel are handled by means of enriching, trapping, separating or sorting. In this study, we report the use of patterning flows produced by a series of grooved surfaces with different geometrical setups integrated into a microfluidic device, to continuously manipulate the flowing particles (5 to 20 μm in diameters) of comparable sizes to the depth of the channel in ways of: 1) concentrating, 2) focusing, and 3) potential separating. The device is fabricated using soft lithographic techniques and is composed of inlets, microfluidic channels, and outlets for loading, manipulating and retrieving cell suspensions, respectively. Such fabrication methods allow rapid prototyping of micron or submicron structures with multiple layers and replica molding on those fabricated features in a clear polymer. The particles are evenly distributed in the entrance of the microchannel and illustrate the enriching, focusing, or size-selective profiles after passing through the patterning grooves. We expect that the techniques of manipulating cell suspensions from this study can facilitate the development of cell-based devices on 1) the visualization of counting, 2) the visualization of sizing, and 3) the particle separating.

Lab on a chip imaging and quantitative phase contrast in turbid microfluidic channel

2012 ◽  
Author(s):  
Melania Paturzo ◽  
Andrea Finizio ◽  
Pasquale Memmolo ◽  
Roberto Puglisi ◽  
Donatella Balduzzi ◽  
...  
Keyword(s):  
Phase Contrast ◽  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Quantitative Phase

Micro-Laser Welding of Plastics for the Applications in Micro-Fluidic Devices

2010 ◽  
Vol 447-448 ◽  
pp. 745-749
Author(s):  
Gui Jun Bi ◽  
Sum Huan Ng ◽  
Khin Thet May ◽  
Cong Zhi Chan
Keyword(s):  
Laser Welding ◽  
Welding Process ◽  
Cross Sectional ◽  
Lap Shear ◽  
Lap Shear Test ◽  
Micro Channels ◽  
Fluidic Devices ◽  
Sectional Analysis ◽  
Micro Laser Welding ◽  
Clamping Pressure

This study aims to investigate laser welding process for the bonding of micro-fluidic devices. PMMA was selected for the investigation. The devices consist of an opaque substrate with micro-channels and a transparent cover. The welding process was optimized according to laser power, welding speed and clamping pressure. The cross-sectional analysis, flow and pressure tests, as well as the lap-shear test were conducted on the samples welded with the optimized process parameters. The results show that the laser welding can meet the requirements for bonding the plastic micro-fluidic devices.

scholarly journals Modeling and Analysis of Opto-Fluidic Sensor for Lab-On- a-Chip Application

2017 ◽  
Author(s):  
Venkatesha M. ◽  
Chaya B. M. ◽  
Pattnaik P. K. ◽  
Narayan K.
Keyword(s):  
Continuous Flow ◽  
Microfluidic Channel ◽  
Optical Loss ◽  
Lab On A Chip ◽  
Single Mode ◽  
Fluidic Channel ◽  
Modeling And Analysis ◽  
Micro Particles ◽  
Sensing Applications ◽  
Integrated Optical

In this work modeling and analysis of an integrated opto-fluidic sensor, with a focus on achievement of single mode optical confinement and continuous flow of micro particles in the microfluidic channel for Lab-on-a Chip (LOC) sensing application is presented. This sensor consists of integrated optical waveguides, microfluidic channel among other integrated optical components. A continuous flow of micro particles in a narrow fluidic channel is achieved by maintaining the two sealed chambers at different temperatures and by maintaining a constant pressure of 1Pa at the centroid of narrow fluidic channel geometry. The analysis of silicon on insulator (SOI) integrated optical waveguide at an infrared wavelength of 1550nm for single mode sensing operation is presented. The optical loss is found to be 0.0005719dB/cm with an effective index of 2.2963. The model presented in this work can be effectively used to detect the nature of micro particles and continuous monitoring of pathological parameters for sensing applications.

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