Transcutaneous Drug Delivery: A Practical Review

1995 ◽  
Vol 70 (6) ◽  
pp. 581-586 ◽  
Author(s):  
Jeffrey J. Berti ◽  
James J. Lipsky
Keyword(s):  
Drug Delivery ◽  
Transcutaneous Drug Delivery

scholarly journals Transcutaneous Drug Delivery Systems Based on Collagen/Polyurethane Composites Reinforced with Cellulose

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1845
Author(s):  
Narcis Anghel ◽  
Valentina Maria Dinu ◽  
Liliana Verestiuc ◽  
Irene Alexandra Spiridon
Keyword(s):  
Drug Delivery ◽  
Compressive Strength ◽  
Elastic Modulus ◽  
Metal Complex ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Fickian Diffusion ◽  
Mechanical Resistance ◽  
Natural Polymers ◽  
Transcutaneous Drug Delivery

Designing composites based on natural polymers has attracted attention for more than a decade due to the possibility to manufacture medical devices which are biocompatible with the human body. Herein, we present some biomaterials made up of collagen, polyurethane, and cellulose doped with lignin and lignin-metal complex, which served as transcutaneous drug delivery systems. Compared with base material, the compressive strength and the elastic modulus of biocomposites comprising lignin or lignin-metal complex were significantly enhanced; thus, the compressive strength increased from 61.37 to 186.5 kPa, while the elastic modulus increased from 0.828 to 1.928 MPa. The release of ketokonazole from the polymer matrix follows a Korsmeyer–Peppas type kinetics with a Fickian diffusion. All materials tested were shown to be active against pathogenic microorganisms. The mucoadhesiveness, bioadhesiveness, mechanical resistance, release kinetic, and antimicrobial activity make these biocomposites to be candidates as potential systems for controlled drug release.

The rise of transcutaneous drug delivery for the management of alopecia: a review of existing literature and an eye towards the future

2018 ◽  
Vol 21 (5) ◽  
pp. 247-254 ◽  
Author(s):  
Angela Wipf ◽  
Nicholas Boysen ◽  
Maria K. Hordinsky ◽  
Emily E. Dando ◽  
Neil Sadick ◽  
...  
Keyword(s):  
Drug Delivery ◽  
The Future ◽  
Transcutaneous Drug Delivery

scholarly journals Facilitation of transcutaneous drug delivery and vaccine immunization by a safe laser technology

2012 ◽  
Vol 159 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Xinyuan Chen ◽  
Dilip Shah ◽  
Garuna Kositratna ◽  
Dieter Manstein ◽  
Richard R. Anderson ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Laser Technology ◽  
Transcutaneous Drug Delivery

Transcutaneous drug delivery by liposomes using fractional laser technology

2016 ◽  
Vol 49 (5) ◽  
pp. 525-532 ◽  
Author(s):  
Takahiro Fujimoto ◽  
Jian Wang ◽  
Kazuki Baba ◽  
Yuka Oki ◽  
Yuki Hiruta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fractional Laser ◽  
Laser Technology ◽  
Transcutaneous Drug Delivery

Performance and characteristics evaluation of a sodium hyaluronate-based microneedle patch for a transcutaneous drug delivery system

2013 ◽  
Vol 441 (1-2) ◽  
pp. 570-579 ◽  
Author(s):  
Yasuhiro Hiraishi ◽  
Takeshi Nakagawa ◽  
Ying-Shu Quan ◽  
Fumio Kamiyama ◽  
Sachiko Hirobe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sodium Hyaluronate ◽  
Transcutaneous Drug Delivery ◽  
Microneedle Patch

Advancement of Lipid-Based Nanocarriers and Combination Application with Physical Penetration Technique

2019 ◽  
Vol 16 (4) ◽  
pp. 312-324 ◽  
Author(s):  
Meng Yang ◽  
Yongwei Gu ◽  
Xiaomeng Tang ◽  
Ting Wang ◽  
Jiyong Liu
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Special Focus ◽  
Transdermal Drug Delivery System ◽  
Penetration Enhancement ◽  
Combined Use ◽  
Transcutaneous Drug Delivery ◽  
Composition Characteristic ◽  
Single Use ◽  
Dermal Drug Delivery

On account of the advantages of transdermal delivery and the application situation of transcutaneous technology in transdermal delivery, the article critically comments on nanosystems as permeation enhancement model. Nanosystems possess great potential for transcutaneous drug delivery. This review focuses on recent advances in lipid-based nanocarriers, including liposome, transfersomes, ethosomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and combination application of the lipid-based nanocarriers with microneedle, iontophoresis, electroporation and sonophoresis in the field for the development of the transdermal drug delivery system. We attempted to give an overview of lipid-based nanocarriers with the aim to improve transdermal and dermal drug delivery. A special focus is given to the nanocarrier composition, characteristic and interaction mechanisms through the skin. Recent combination applications of lipid-based nanocarriers with the physical penetration technology demonstrate the superiority of the combined use of nanocarriers and physical methods in drug penetration enhancement compared to their single use. In the future, lipidbased nanocarriers will play a greater role in the field of transdermal and dermal drug delivery.

Fractional CO2 Laser for Transcutaneous Drug Delivery of Onabotulinum Toxin in Palmar Hyperhidrosis

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Naglaa F. Agamia ◽  
Nagat Sobhy ◽  
Amira Abd-Elraouf ◽  
Abeer Tawfik
Keyword(s):  
Drug Delivery ◽  
Co2 Laser ◽  
Palmar Hyperhidrosis ◽  
Fractional Co2 Laser ◽  
Transcutaneous Drug Delivery
Sign in / Sign up

Export Citation Format

Share Document