scholarly journals Benefits from Treatment and Control of Patients with Resistant Hypertension

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Michael Doumas ◽  
Vasilios Papademetriou ◽  
Stella Douma ◽  
Charles Faselis ◽  
Konstantinos Tsioufis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Resistant Hypertension ◽  
Critical Evaluation ◽  
Renal Sympathetic Denervation ◽  
Therapeutic Modalities ◽  
Carotid Baroreceptor ◽  
Baroreceptor Stimulation ◽  
And Control ◽  
Renal Sympathetic ◽  
Carotid Baroreceptor Stimulation

Resistant hypertension is commonly found in everyday clinical practice. However, the risks of resistant hypertension, as well as the benefits of treatment and control of blood pressure in patients with resistant hypertension remain vaguely clarified. Data from small clinical studies and observational cohorts suggest that patients with resistant hypertension are at increased cardiovascular risk, while control of blood pressure offers substantial benefits. It has to be noted however that data from appropriate large randomized studies are missing, and resistant hypertension remains remarkably understudied. Resistant hypertension has attracted significant scientific interest lately, as new therapeutic modalities become available. The interventional management of resistant hypertension either by carotid baroreceptor stimulation or renal sympathetic denervation is currently under investigation with promising preliminary results. This review presents available evidence regarding the benefits of treatment and control of blood pressure in patients with resistant hypertension and offers a critical evaluation of existing data in this field.

scholarly journals Carotid Baroreceptor Stimulation for the Treatment of Resistant Hypertension

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Vasilios Papademetriou ◽  
Michael Doumas ◽  
Charles Faselis ◽  
Constantinos Tsioufis ◽  
Stella Douma ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Resistant Hypertension ◽  
Blood Pressure Reduction ◽  
Current Data ◽  
Pressure Reduction ◽  
Beneficial Effects ◽  
Carotid Baroreceptor ◽  
Complex Anatomy ◽  
Baroreceptor Stimulation ◽  
Carotid Baroreceptor Stimulation

Interventional activation of the carotid baroreflex has been an appealing idea for the management of resistant hypertension for several decades, yet its clinical application remained elusive and a goal for the future. It is only recently that the profound understanding of the complex anatomy and pathophysiology of the circuit, combined with the accumulation of relevant experimental and clinical data both in animals and in humans, has allowed the development of a more effective and well-promising approach. Indeed, current data support a sustained over a transient reduction of blood pressure through the resetting of baroreceptors, and technical deficits have been minimized with a subsequent recession of adverse events. In addition, clinical outcomes from the application of a new implantable device (Rheos) that induces carotid baroreceptor stimulation point towards a safe and effective blood pressure reduction, but longer experience is needed before its integration in the everyday clinical practice. While accumulating evidence indicates that carotid baroreceptor stimulation exerts its benefits beyond blood pressure reduction, further research is necessary to assess the spectrum of beneficial effects and evaluate potential hazards, before the extraction of secure conclusions.

Renal and Cardiac Effects of Renal Sympathetic Denervation and Carotid Baroreceptor Stimulation

2014 ◽  
Vol 12 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Costas Tsioufis ◽  
Kyriakos Dimitriadis ◽  
Costas Thomopoulos ◽  
Michalis Doumas ◽  
Vasilios Papademetriou ◽  
...  
Keyword(s):  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Cardiac Effects ◽  
Carotid Baroreceptor ◽  
Baroreceptor Stimulation ◽  
Renal Sympathetic ◽  
Carotid Baroreceptor Stimulation

Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension

2015 ◽  
Vol 33 (12) ◽  
pp. 2512-2518 ◽  
Author(s):  
Sebastian Ewen ◽  
Oliver Dörr ◽  
Christian Ukena ◽  
Dominik Linz ◽  
Bodo Cremers ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Resistant Hypertension ◽  
Blood Pressure Variability ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Renal Sympathetic

scholarly journals Effects of Renal Sympathetic Denervation on Blood Pressure, Sleep Apnea Course, and Glycemic Control in Patients With Resistant Hypertension and Sleep Apnea

Hypertension ◽  
2011 ◽  
Vol 58 (4) ◽  
pp. 559-565 ◽  
Author(s):  
Adam Witkowski ◽  
Aleksander Prejbisz ◽  
Elżbieta Florczak ◽  
Jacek Kądziela ◽  
Paweł Śliwiński ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sleep Apnea ◽  
Glycemic Control ◽  
Resistant Hypertension ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Renal Sympathetic
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