scholarly journals Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Suleiman F. Ambali ◽  
Chinedu Orieji ◽  
Woziri O. Abubakar ◽  
Muftau Shittu ◽  
Mohammed U. Kawu
Keyword(s):  
Vitamin C ◽  
Thyroid Hormones ◽  
Wistar Rats ◽  
Low Dose ◽  
Antioxidant Properties ◽  
Thyroid Stimulating Hormone ◽  
Group Iv ◽  
Group Iii ◽  
Ameliorative Effect ◽  
Soya Oil

The present study evaluated the ameliorative effect of vitamin C on alteration in thyroid hormones induced by low-dose subchronic coadministration of chlorpyrifos (CPF) and lead (Pb). Forty Wistar rats were divided into 4 groups of 10 animals each. Groups I and II were administered soya oil (2 mL/kg) and vitamin C (100 mg/kg), respectively. Group III was coadministered CPF (4.25 mg/kg ~1/20th LD50) and Pb (250 mg/kg ~1/20th LD50), respectively. Group IV was pretreated with vitamin C (100 mg/kg) and then coadministered with CPF (4.25 mg/kg) and Pb (250 mg/kg), 30 min later. The regimens were administered by gavage for a period of 9 weeks. The marginal decrease in serum triiodothyronine and thyroxine and the significant increase in the concentrations of thyroid stimulating hormone and malonaldehyde in the group coadministered with CPF and Pb were ameliorated by vitamin C partly due to its antioxidant properties.

scholarly journals Piperine Enhances the Antioxidant and Anti-Inflammatory Activities of Thymoquinone against Microcystin-LR-Induced Hepatotoxicity and Neurotoxicity in Mice

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Mohamed M. Abdel-Daim ◽  
Amany A. Sayed ◽  
Ahmed Abdeen ◽  
Lotfi Aleya ◽  
Daoud Ali ◽  
...  
Keyword(s):  
Health Hazard ◽  
Antioxidant Properties ◽  
Group Iv ◽  
Significant Elevation ◽  
Freshwater Environment ◽  
Concurrent Treatment ◽  
Group Iii ◽  
Group I ◽  
Transport Chain ◽  
Ameliorative Effect

Microcystin- (MC-) LR is the most frequent cyanotoxin produced byMicrocystis aeruginosacyanobacteria in the contaminated freshwater environment. MC represents a health hazard to humans and animals. Therefore, the present study was designed to evaluate the potential ameliorative effect of thymoquinone (TQ) and/or piperine (PP) against MC toxicity in mice. Fifty-six mice were randomly divided into seven experimental groups. Group I is the normal control that received distilled water for 21 days; Group II (TQ) was treated with TQ (10 mg/kg, i.p) for 21 days; Group III (PP) was treated with PP (25 mg/kg, i.p) for 21 days; Group IV (MC) was treated with MC (10 μg/kg, i.p) for 14 days and served as the toxic control; and Groups V, VI, and VII received TQ and/or PP 7 days prior to MC and continued for 14 days with MC. The results revealed that MC elicited hepatotoxicity and neurotoxicity which was evident due to the significant elevation of serum AST, ALT,γGT, ALP, LDH, IL-1β, IL-6, and TNF-αlevels. Furthermore, MC markedly increased MDA and NO contents along with reduction of GSH, SOD, CAT, and GSH-Px in liver and brain tissues. The electron transport chain may be a possible target for MC. TQ and/or PP ameliorated the MC-mediated oxidative damage in the liver and brain which might be attributed to their antioxidant properties. However, the concurrent treatment of TQ and PP showed the best regimen as a result of the PP-enhanced bioavailability of TQ.

scholarly journals Impact of vitamin C on concentrations of thyroid stimulating hormone and thyroid hormones in lambs under short-term acute heat stress

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Arash Omidi ◽  
Masoumeh Kheirie ◽  
Hadi Sarir
Keyword(s):  
Heat Stress ◽  
Vitamin C ◽  
Thyroid Hormones ◽  
Antioxidant Properties ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Control Group ◽  
Short Term ◽  
Acute Heat Stress ◽  
Humidity Index

The present study evaluated the effect of vitamin C on alteration in thyroid hormones induced by short-term acute heat stress. Eight male lambs were divided into two groups of 4 animals each. Both groups were placed in an environment with hyper-acute heat stress based on the temperature – humidity index (THI). Groups I and II were injected intramuscularly normal saline and vitamin C (20 mg/kg), respectively, for the first five consecutive days of the experiment. All lambs were fed ad libitum. Blood samples were collected from both groups on days one, two, four, six and eight. Thyroxine and free thyroxine numerically increased (91.03 vs. 70.78 nmol L-1, P=0.080 and 29.8 vs. 24.8 pmol L-1, P=0.080; respectively) in heat stressed lambs supplemented with vitamin C compared to control group. Respiration rates and heart rates were elevated until day five of the experiment and then decreased. Mechanism for increasing the levels of thyroxine and free thyroxine by vitamin C is not well known. However, it may occur in part because of vitamin C antioxidant properties. The present study revealed that vitamin C might ameliorate the adverse effect of heat stress in lambs.

Ameliorative effect of vitamin C on the haematological changes induced by exposure of chlorpyriphos and lead acetate in Wistar rats

2013 ◽  
Vol 23 (4) ◽  
pp. 829-834
Author(s):  
Nisar Ahmad Nisar ◽  
Mudasir Sultana ◽  
Naseer Ahmad Baba ◽  
Parveez Ahmad Para ◽  
Hina Ashraf Waiz ◽  
...  
Keyword(s):  
Vitamin C ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Ameliorative Effect ◽  
Haematological Changes

scholarly journals Protective effect of Berberis asiatica root on biochemical and histopathological changes in streptozotocin-induced diabetic Wistar rats

2017 ◽  
Vol 6 (8) ◽  
pp. 1880 ◽  
Author(s):  
Mohd Muddassir Husain Khan ◽  
Chetan Rastogi ◽  
Sachin Gupta ◽  
Shravan Kumar Paswan ◽  
Pritt Verma ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Liver Function ◽  
Blood Glucose Level ◽  
Protective Effect ◽  
Glucose Level ◽  
Wistar Rats ◽  
Total Bilirubin ◽  
Group Iv ◽  
Group Iii ◽  
Group I

Background: This study was designed to evaluate the effect of Berberis asiatica root extract (BAE) against streptozotocin induced elevated blood glucose level and other liver and kidney functions changes in adult male Wistar rats.Methods: Thirty male Wistar rats were divided into five groups of six rats in each (Groups I-V). Group I and Group II served as normal control and disease control, respectively. Group III received standard anti-diabetic drug glibenclamide (5mg/kg), while Group IV and Group V received the low dose (250mg/kg) and high dose (500mg/kg) of BAE. Serum blood glucose, SGOT, SGPT, ALP, total bilirubin, BUN, serum creatinine, TC, TG, HDL-C, LDL-C, and VLDL-C were estimated using standard methods. After collection of samples for biochemical evaluation, the pancreas from each animal was isolated and examined for histological changes.Results: BAE and glibenclamide treated disease rats showed significant (p <0.05) decrease in blood glucose concentration. Treatment with BAE at 250mg/kg and 500mg/kg in Group IV and V and standard drug glibenclamide in Group III showed significant (p <0.05) reduction in the level of liver function substances such as SGOT, SGPT, ALP and total bilirubin as compared to disease group, as well as showed significant (p <0.05) decrease in renal panel. Liver function parameters were significantly (p <0.05) improved in groups treated with BAE. Histopathological analysis revealed the protective effect of BAE against streptozotocin induced damage to islets of Langerhans.Conclusions: This study showed the destruction of islets of Langerhans and elevation in blood glucose level as well as alteration in other biochemical parameters were ameliorated by the effect of Berberis asiatica extract.

scholarly journals CHEMICAL AND PHENOTYPIC DIVERSITY OF MEXICAN PLUMS (Spondias purpurea L.) FROM THE STATES OF GUERRERO AND MORELOS, MEXICO

2017 ◽  
Vol 39 (2) ◽  
Author(s):  
YANIK IXCHEL MALDONADO ASTUDILLO ◽  
IRÁN ALIA TEJACAL ◽  
ALBERTO CARLOS NÚÑEZ-COLÍN ◽  
JAVIER JIMÉNEZ HERNÁNDEZ ◽  
VÍCTOR LÓPEZ MARTÍNEZ
Keyword(s):  
Phenotypic Diversity ◽  
Antioxidant Properties ◽  
Group Iv ◽  
Pulp Yield ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Red Color ◽  
Spondias Purpurea ◽  
Species Variability

ABSTRACT Fruits from 86 ecotypes of Mexican plum were harvested from the states of Guerrero and Morelos during the dry season. Of these, 22 were wild ecotypes and 64 were cultivated varieties. Among the variables measured, those with the highest variation coefficients were color, flavor, and mass (> 45%), highlighting the presence of considerable intra-species variability. Cluster analysis separated the 86 accessions into 5 groups, mainly on the basis of color, flavor, length, and mass. Members from the first three groups had red (Group I), yellow (Group II), or purple (Group III) epicarps and higher values of mass (12.2-16 g), length (29.6-33.9 mm), pulp yield (68.8-71.9% ), TSS (11.16-11.52 °Brix) and flavor index (14.5-18.3), making them suitable for horticultural use and fresh consumption. The wild ecotypes clustered in the remaining two groups and consisted of small (23.2-27.7 mm, 5.5-8.2 g) red drupes of differing hues. The cherry-red color of the fruits from Group IV suggests possible antioxidant properties due to the presence of polyphenolic pigments which could be of interest to the pharmaceutical and cosmetic industries. Finally, fruits from Group V, being the most acidic (pH 2.7, 2.1% acidity), might be better suited for the preparation of pickled products and sauces.

scholarly journals Selenium supplementation ameliorated paraquat-induced haemotoxicity in male rats

2020 ◽  
pp. 17-21
Keyword(s):  
Group Iv ◽  
Selenium Supplementation ◽  
Male Rats ◽  
Haematological Parameters ◽  
Group V ◽  
Once Daily ◽  
Group Iii ◽  
Group I ◽  
Ameliorative Effect ◽  
Haematological Changes

Introduction: The study was aimed at determining the haematological changes induced by 7 days paraquat exposure in rats and the ameliorative effect of selenium. Methods: Fifty-two adult male rats weighing between 150g and 200g were used for the study. The animals re randomly divided into five (5) groups of eight (8) rats each viz: Group I (DW) was administered distilled water only (2 ml/kg), group II (P1) was paraquat 15 mg/kg, group III (P1 + S) was paraquat (15 mg/kg) and selenium (0.3 mg/kg) an hour later, group IV (P2) was paraquat 30 mg/kg, while group V (P2 + S) was paraquat (30 mg/kg) and selenium (0.3 mg/kg) an hour later. Treatments were administered per os by gavage once daily for a week. Blood samples were analysed on the last day of administration. Results: The results of the study revealed that there were no significant differences (p >0.05) in haematological parameters in paraquat-induced toxicity in rats. Significance: The result of this research has shown that 7 days paraquat administration at 15 and 30 mg/kg has no detrimental effect on haematological parameters in rats, thus selenium supplementation cannot be justified to ameliorate its effect.

scholarly journals The Hepatoprotector Effect of Uncaria gambir Roxb Extract in Wistar Rats Induced by Paracetamol

2020 ◽  
Vol 10 (6-s) ◽  
pp. 61-66
Author(s):  
, Suparni ◽  
, Musthari ◽  
Liza Mutia ◽  
Mangoloi Sinurat ◽  
Siti Syarifah ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Chronic Administration ◽  
Liver Cells ◽  
Group Iv ◽  
Drug Induced ◽  
Significant Differentiation ◽  
Group Iii ◽  
Hepatoprotector Activity ◽  
Group I ◽  
Group Ii

Background: Drug induced liver injury (DILI) is known as the damage of liver cells due to chronic administrations of drug. The chronic administration of paracetamol could be trigger the damage of liver cells.The hepatoprotector agents are still limited worldwide.  Gambier(Uncaria gambir Roxb) is an Indonesia’traditional medicine which have many benefits as antioxidant, antiseptic, antidiarrhoea, etc  that commonly used in society.  Method: The present study was conducted to investigate the hepatoprotector effect ofgambier in wistar rats induced by paracetamol.  The wistar rats were divided into seven groups and received the treatment orally for 12 days. Group I (aquadest), II(curcuma,400 mg/kgBW),III (gambier,26 mg/200gr), IV(gambier, 53 mg/200gr), V(gambier,106 mg/200gr),VI(gambier,212 mg/200gr) and VII(gambier,424mg/200gr). Termination, blood and liver organ collection were done after all group induced by paracetamol for two days. Histopatology changes of liver were examined using Hematoxycilline (HE) staining. AST and ALT levels were analyzed. Results: There were significant differentiation of AST levels among the groups, especially between group I and group IV and between group II and group IV. The ALT levels were statistically significant between group II and group V using Mann-Whitney test (p<0,05). In histopatology examination, there were significant differentiation between group I with another group, not only group II but also group III-VII (p<0,05). In the treatment group, group III and IV had been showed the improvement of liver cells damage than group I by using One-way Annova, post hoc Bonferroni (p<0,05). Conclusion: Uncaria gambir Roxb has hepatoprotector activity start at dose 53 mg/200grBWin rats.  The hepatoprotector activity was not superior than curcuma.  Keywords: hepatoprotector, Uncaria gambir Roxb, AST,ALT,histopatology

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