scholarly journals Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids

2010 ◽  
Vol 2010 ◽  
pp. 1-13
Author(s):  
Etsuko Kawashima ◽  
Yusuke Ohba ◽  
Yusuke Terui ◽  
Kazuo Kamaike
Keyword(s):  
Dna Binding ◽  
Binding Specificity ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Design Synthesis ◽  
Distamycin A ◽  
Sequence Selectivity ◽  
Binding Sequence

Pyrrolepolyamide-2′-deoxyguanosine hybrids (Hybrid2and Hybrid3) incorporating the 3-aminopropionyl or 3-aminopropyl linker were designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Hybrid1). Evaluation of the DNA binding sequence selectivity of pyrrolepolyamide-2′-deoxyguanosine hybrids was performed by CD spectral andTmanalyses. It was shown that Hybrid3possessed greater binding specificity than distamycin A, Hybrid1and Hybrid2.

Design, Synthesis, and Biological Activity of Hybrid Compounds between Uramustine and DNA Minor Groove Binder Distamycin A

2002 ◽  
Vol 45 (17) ◽  
pp. 3630-3638 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Romeo Romagnoli ◽  
Antonio Entrena Guadix ◽  
Maria Josè Pineda de las Infantas ◽  
Miguel Angel Gallo ◽  
...  
Keyword(s):  
Biological Activity ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Design Synthesis ◽  
Distamycin A ◽  
Dna Minor Groove ◽  
Hybrid Compounds ◽  
Dna Minor Groove Binder

Design, Synthesis and in vitro Cytotoxicity of a cis-Dichloroplatinum (II) Complex Linked to the Minor Groove Binder Stallimycin

2011 ◽  
Vol 53 (02) ◽  
pp. 107-113
Author(s):  
Pier Baraldi ◽  
Mojgan Tabrizi ◽  
Maria Pavani ◽  
Maria Nuñez ◽  
Rimma Makaeva ◽  
...  
Keyword(s):  
Minor Groove ◽  
In Vitro Cytotoxicity ◽  
Minor Groove Binder ◽  
Design Synthesis

Design, Synthesis, and in Vitro Evaluation of Dipeptide-Based Antibody Minor Groove Binder Conjugates

2005 ◽  
Vol 48 (5) ◽  
pp. 1344-1358 ◽  
Author(s):  
Scott C. Jeffrey ◽  
Michael Y. Torgov ◽  
Jamie B. Andreyka ◽  
Laura Boddington ◽  
Charles G. Cerveny ◽  
...  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binder ◽  
Design Synthesis ◽  
In Vitro Evaluation

DNA Binding Compounds. VII. Synthesis, Characterization and DNA Binding Capacity of 1,2-Dicarba-closo-dodecaborane Bibenzimidazoles Related to the DNA Minor Groove Binder Hoechst 33258

1999 ◽  
Vol 52 (4) ◽  
pp. 291 ◽  
Author(s):  
Stuart A. Bateman ◽  
David P. Kelly ◽  
Jonathan M. White ◽  
Roger F. Martin
Keyword(s):  
Dna Binding ◽  
Binding Capacity ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Hoechst 33258 ◽  
Binding Studies ◽  
Dna Minor Groove ◽  
Dna Binding Studies ◽  
Carborane Ligand ◽  
Dna Minor Groove Binder

A series of bibenzimidazole derivatives based on the known DNA minor groove binder Hoechst 33258 have been prepared to include a 1,2-dicarba-closo-dodecaborane cage for potential use in boron neutron capture therapy (BNCT). The carborane derivatives (5){(7) were chosen to reduce the steric inhibition of minor groove DNA binding displayed by the previously prepared carborane ligand (4). The synthesis and preliminary DNA binding studies of these bibenzimidazole derivatives are presented herein.

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