scholarly journals Platelet-Derived Growth Factor Receptor-Positive Pericytic Cells of White Adipose Tissue from Critical Limb Ischemia Patients Display Mesenchymal Stem Cell-Like Properties

2017 ◽  
Vol 9 (2) ◽  
pp. 239 ◽  
Author(s):  
Eo Jin Kim ◽  
Sang Gyo Seo ◽  
Hyuk Soo Shin ◽  
Doo Jae Lee ◽  
Ji Hye Kim ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Growth Factor ◽  
Mesenchymal Stem Cell ◽  
White Adipose Tissue ◽  
Critical Limb Ischemia ◽  
Growth Factor Receptor ◽  
Limb Ischemia ◽  
Platelet Derived Growth Factor

Developmentally regulated use of alternative promoters creates a novel platelet-derived growth factor receptor transcript in mouse teratocarcinoma and embryonic stem cells

1989 ◽  
Vol 9 (10) ◽  
pp. 4563-4567
Author(s):  
T H Vu ◽  
G R Martin ◽  
P Lee ◽  
D Mark ◽  
A Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Growth Factor ◽  
Short Form ◽  
Embryonic Stem ◽  
Growth Factor Receptor ◽  
Extracellular Domain ◽  
Platelet Derived Growth Factor ◽  
Alternative Promoters

Embryonal carcinoma and embryonic stem cells expressed a novel form of platelet-derived growth factor receptor mRNA which was approximately 1,100 base pairs shorter than the 5.3-kilobase (kb) transcript expressed in fibroblasts and other cell types. The 4.2-kb stem cell transcript was initiated within the genomic region immediately upstream of exon 6 of the 5.3-kb transcript and therefore lacked the first five exons, which encode much of the extracellular domain of the receptor expressed in fibroblasts. In stem cells, the short form was predominant, although both forms were present at low levels. Following differentiation in vitro, expression levels of the long form increased dramatically. These findings suggest that during early embryogenesis, a stem cell-specific promoter is used in a stage- and cell type-specific manner to express a form of the platelet-derived growth factor receptor that lacks much of the extracellular domain and may function independently of ligand.

scholarly journals Safety and Effect of Adipose Tissue-Derived Stem Cell Implantation in Patients With Critical Limb Ischemia

2012 ◽  
Vol 76 (7) ◽  
pp. 1750-1760 ◽  
Author(s):  
Han Cheol Lee ◽  
Sung Gyu An ◽  
Hye Won Lee ◽  
Jin-Sup Park ◽  
Kwang Soo Cha ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Cell Implantation

scholarly journals HIF-Prolyl Hydroxylase 2 Inhibition Enhances the Efficiency of Mesenchymal Stem Cell-Based Therapies for the Treatment of Critical Limb Ischemia

Stem Cells ◽  
2014 ◽  
Vol 32 (1) ◽  
pp. 231-243 ◽  
Author(s):  
Kiave-Yune HoWangYin ◽  
Céline Loinard ◽  
Wineke Bakker ◽  
Coralie L. Guérin ◽  
José Vilar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Prolyl Hydroxylase ◽  
Hif Prolyl Hydroxylase
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