scholarly journals Platelet-derived growth factor-BB is involved in mesenchymal stem cell secretome-induced neuroprotection of retinal ganglion cells

Brain ◽  
2014 ◽  
Vol 137 (5) ◽  
pp. e276-e276 ◽  
Author(s):  
Jian-Li He
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Mesenchymal Stem Cell ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Platelet Derived Growth Factor ◽  
Retinal Ganglion

scholarly journals Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome

Brain ◽  
2013 ◽  
Vol 137 (2) ◽  
pp. 503-519 ◽  
Author(s):  
Thomas V. Johnson ◽  
Nicholas W. DeKorver ◽  
Victoria A. Levasseur ◽  
Andrew Osborne ◽  
Alessia Tassoni ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Mesenchymal Stem Cell ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Platelet Derived Growth Factor ◽  
Retinal Ganglion

scholarly journals Hereditary Optic Neuropathies: Induced Pluripotent Stem Cell-Based 2D/3D Approaches

Genes ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 112
Author(s):  
Marta García-López ◽  
Joaquín Arenas ◽  
M. Esther Gallardo
Keyword(s):  
Stem Cell ◽  
Retinal Ganglion Cells ◽  
Pluripotent Stem Cell ◽  
Ganglion Cells ◽  
Genetic Disorders ◽  
Three Dimensional ◽  
Induced Pluripotent Stem Cell ◽  
Underlying Mechanism ◽  
Retinal Ganglion ◽  
Induced Pluripotent

Inherited optic neuropathies share visual impairment due to the degeneration of retinal ganglion cells (RGCs) as the hallmark of the disease. This group of genetic disorders are caused by mutations in nuclear genes or in the mitochondrial DNA (mtDNA). An impaired mitochondrial function is the underlying mechanism of these diseases. Currently, optic neuropathies lack an effective treatment, and the implementation of induced pluripotent stem cell (iPSC) technology would entail a huge step forward. The generation of iPSC-derived RGCs would allow faithfully modeling these disorders, and these RGCs would represent an appealing platform for drug screening as well, paving the way for a proper therapy. Here, we review the ongoing two-dimensional (2D) and three-dimensional (3D) approaches based on iPSCs and their applications, taking into account the more innovative technologies, which include tissue engineering or microfluidics.

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