Systemic Immune Bias Delineates Malignant Astrocytoma Survival Cohorts

2021 ◽  
Vol 206 (7) ◽  
pp. 1483-1492
Author(s):  
Michael Prosniak ◽  
Larry A. Harshyne ◽  
Jonathan Gorky ◽  
Mark T. Curtis ◽  
Lawrence C. Kenyon ◽  
...  
Keyword(s):  
Malignant Astrocytoma

Malignant astrocytoma following radiotherapy of a craniopharyngioma

1978 ◽  
Vol 48 (4) ◽  
pp. 622-627 ◽  
Author(s):  
Richard L. Sogg ◽  
Sarah S. Donaldson ◽  
Craig H. Yorke
Keyword(s):  
Experimental Evidence ◽  
Temporal Lobe ◽  
Malignant Astrocytoma ◽  
Content Type ◽  
Suprasellar Region ◽  
The Right ◽  
Fine Print

✓ A 9-year-old schoolgirl received 6007 rads to the suprasellar region for craniopharyngioma. Five years later, a malignant astrocytoma developed in the right temporal lobe. We cite clinical and experimental evidence to support our suspicion that the glioma may have been induced by radiation.

Cordotomy for patients with thoracic malignant astrocytoma

2010 ◽  
Vol 13 (4) ◽  
pp. 418-423 ◽  
Author(s):  
Masaya Nakamura ◽  
Osahiko Tsuji ◽  
Kanehiro Fujiyoshi ◽  
Kota Watanabe ◽  
Takashi Tsuji ◽  
...  
Keyword(s):  
Tumor Resection ◽  
Radical Resection ◽  
Subtotal Resection ◽  
Optimal Management ◽  
Malignant Astrocytoma ◽  
Initial Operation ◽  
Who Grade ◽  
Kaplan Meier ◽  
Malignant Astrocytomas ◽  
Grade Ii

Object The optimal management of malignant astrocytomas remains controversial, and the prognosis of these lesions has been dismal regardless of the administered treatment. In this study the authors investigated the surgical outcomes of cordotomy in patients with thoracic malignant astrocytomas to determine the effectiveness of this procedure. Methods Cordotomy was performed in 5 patients with glioblastoma multiforme (GBM) and 2 with anaplastic astrocytoma (AA). A Kaplan-Meier survival analysis was performed, and the associations of the resection level with survival and postoperative complications were retrospectively examined. Results Cordotomy was performed in a single stage in 2 patients with GBM and in 2 stages in 3 patients with GBM and 2 patients with AA. In the 2 patients with GBM, cordotomy was performed 2 and 3 weeks after a partial tumor resection. In the 2 patients with AA, the initial treatment consisted of partial tumor resection and subtotal resection combined with radiotherapy, and rostral tumor growth and progressive paralysis necessitated cordotomy 2 and 28 months later. One patient with a secondary GBM underwent cordotomy; the GBM developed 1 year after subtotal resection and radiotherapy for a WHO Grade II astrocytoma. Four patients died 4, 5, 24, and 42 months after the initial operation due to CSF dissemination, and 3 patients (2 with GBM and 1 with AA) remain alive (16, 39, and 71 months). No metastasis to any other organs was noted. Conclusions One-stage cordotomy should be indicated for patients with thoracic GBM or AA presenting with complete paraplegia preoperatively. In patients with thoracic GBM, even if paralysis is incomplete, cordotomy should be performed before the tumor disseminates through the CSF. Radical resection should be attempted in patients with AA and incomplete paralysis. If the tumor persists, radiotherapy and chemotherapy are indicated, and cordotomy should be reserved for lesions growing progressively after such second-line treatments.

scholarly journals Targeted Therapy for BRAFV600E Malignant Astrocytoma

2011 ◽  
Vol 17 (24) ◽  
pp. 7595-7604 ◽  
Author(s):  
Theodore P. Nicolaides ◽  
Huifang Li ◽  
David A. Solomon ◽  
Sujatmi Hariono ◽  
Rintaro Hashizume ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Malignant Astrocytoma

scholarly journals The evaluation of malignant astrocytoma score (MAS)

2013 ◽  
Vol 70 (5) ◽  
pp. 452-456
Author(s):  
Zeljko Kojadinovic ◽  
Petar Vulekovic ◽  
Djordje Jajic ◽  
Tomislav Cigic ◽  
Vladimir Papic ◽  
...  
Keyword(s):  
Performance Status ◽  
Radiation Therapy Oncology Group ◽  
Scoring Systems ◽  
Hospital Treatment ◽  
Malignant Astrocytoma ◽  
Or Groups ◽  
The Mean ◽  
The Moment ◽  
Astrocytoma Grade Iii

Background/Aim. At the moment there are few scoring systems for malignant astrocytoma but they are not widely accepted. The aim of this study was to evaluate malignant astrocytoma score (MAS) on a new group of patients with malignant astrocytoma, to compare MAS with other prognostic tools and to describe the use of MAS in everyday practice in neurooncology. Methods. The study was performed on 124 patients with supratentorial malignant astrocytoma grade III or IV. They were operated on and subsequently irradiated with 50-60 Gy. Results. The mean age of the patients was 57.3 years. The mean Karnofski performance status (KPS) of the functional inpairment was 54. The removal of the tumor > 90% was done in 59.7% of patients. The mean survival was 9.1 months, and 27.4% of patients had a 12-month survival. The area under receiver operating characteristic (ROC) curve (AUC) of the MAS for predicting 6-, 12- and 18-month survival was 0.754, 0.783 and 0.882, respectively. We compared the MAS with the two mostly cited scoring systems. The AUC for the same prediction for medical research council (MRC) was 0.601, 0.693, 0.772 respectively. For the Radiation Therapy Oncology Group (RTOG) the AUC was 0.732, 0.765, 0.827, respectively. Conclusion. MAS represents a useful scoring system for determining illness severity and prognosis in patients with malignant supratentorial astrocytoma. It can be helpful in comparing single patients or groups of patients, as well as results of different treatments and in controlling the quality of hospital treatment and so on.

Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma

2010 ◽  
Vol 1352 ◽  
pp. 200-207 ◽  
Author(s):  
Bin Li ◽  
Xiang-Qian Qi ◽  
Xin Chen ◽  
Xin Huang ◽  
Guo-Ying Liu ◽  
...  
Keyword(s):  
Malignant Astrocytoma

scholarly journals A malignant astrocytoma with uncommon angiocentric features and dot-like EMA expression

2018 ◽  
Vol 22 (3) ◽  
pp. 205-208
Author(s):  
Wojciech Kuncman ◽  
Marcin Braun ◽  
Łukasz Kuncman ◽  
Piotr Kupnicki ◽  
Michał Piotrowski ◽  
...  
Keyword(s):  
Malignant Astrocytoma

p53 abnormality and tumor invasion in patients with malignant astrocytoma

2010 ◽  
Vol 27 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Hiroyuki Momota ◽  
Yoshitaka Narita ◽  
Yuko Matsushita ◽  
Yasuji Miyakita ◽  
Soichiro Shibui
Keyword(s):  
Tumor Invasion ◽  
Malignant Astrocytoma

Migration of fresh human malignant astrocytoma cells into hydrated gel wafers in vitro

1994 ◽  
pp. 63-73
Author(s):  
Jerald J. Bernstein ◽  
William J. Goldberg ◽  
Edward R. Laws
Keyword(s):  
Malignant Astrocytoma ◽  
Astrocytoma Cells
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