scholarly journals γδ T Cells Kill Plasmodium falciparum in a Granzyme- and Granulysin-Dependent Mechanism during the Late Blood Stage

2020 ◽  
Vol 204 (7) ◽  
pp. 1798-1809 ◽  
Author(s):  
Maria Andrea Hernández-Castañeda ◽  
Katharina Happ ◽  
Filippo Cattalani ◽  
Alexandra Wallimann ◽  
Marianne Blanchard ◽  
...  
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Γδ T Cells ◽  
Blood Stage ◽  
Dependent Mechanism

scholarly journals Cutting Edge: Spontaneous Development of IL-17–Producing γδ T Cells in the Thymus Occurs via a TGF-β1–Dependent Mechanism

2010 ◽  
Vol 184 (4) ◽  
pp. 1675-1679 ◽  
Author(s):  
Jeong-su Do ◽  
Pamela J. Fink ◽  
Lily Li ◽  
Rosanne Spolski ◽  
Janet Robinson ◽  
...  
Keyword(s):  
T Cells ◽  
Γδ T Cells ◽  
Cutting Edge ◽  
Tgf Β1 ◽  
Dependent Mechanism

scholarly journals Roles of IFN-γ and γδ T Cells in Protective Immunity Against Blood-Stage Malaria

2013 ◽  
Vol 4 ◽  
Author(s):  
Shin-Ichi Inoue ◽  
Mamoru Niikura ◽  
Shoichiro Mineo ◽  
Fumie Kobayashi
Keyword(s):  
T Cells ◽  
Protective Immunity ◽  
Γδ T Cells ◽  
Blood Stage ◽  
Ifn Γ ◽  
Blood Stage Malaria

Plasmodium berghei XAT: Contribution of γδ T cells to host defense against infection with blood-stage nonlethal malaria parasite

2007 ◽  
Vol 117 (4) ◽  
pp. 368-375 ◽  
Author(s):  
Fumie Kobayashi ◽  
Mamoru Niikura ◽  
Seiji Waki ◽  
Toshihiro Matsui ◽  
Takashi Fujino ◽  
...  
Keyword(s):  
T Cells ◽  
Host Defense ◽  
Plasmodium Berghei ◽  
Malaria Parasite ◽  
Γδ T Cells ◽  
Blood Stage

scholarly journals Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell–invasive merozoites

Blood ◽  
2011 ◽  
Vol 118 (26) ◽  
pp. 6952-6962 ◽  
Author(s):  
Giulia Costa ◽  
Séverine Loizon ◽  
Marianne Guenot ◽  
Iulia Mocan ◽  
Franck Halary ◽  
...  
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
T Cell ◽  
Blood Cell ◽  
Parasite Density ◽  
Red Blood Cell ◽  
Γδ T Cells ◽  
Γδ T Cell ◽  
Antiparasitic Activity ◽  
Vγ9vδ2 T Cells

AbstractThe control of Plasmodium falciparum erythrocytic parasite density is essential for protection against malaria, because it prevents pathogenesis and progression toward severe disease. P falciparum blood-stage parasite cultures are inhibited by human Vγ9Vδ2 γδ T cells, but the underlying mechanism remains poorly understood. Here, we show that both intraerythrocytic parasites and the extracellular red blood cell–invasive merozoites specifically activate Vγ9Vδ2 T cells in a γδ T cell receptor–dependent manner and trigger their degranulation. In contrast, the γδ T cell–mediated antiparasitic activity only targets the extracellular merozoites. Using perforin-deficient and granulysin-silenced T-cell lines, we demonstrate that granulysin is essential for the in vitro antiplasmodial process, whereas perforin is dispensable. Patients infected with P falciparum exhibited elevated granulysin plasma levels associated with high levels of granulysin-expressing Vδ2+ T cells endowed with parasite-specific degranulation capacity. This indicates in vivo activation of Vγ9Vδ2 T cells along with granulysin triggering and discharge during primary acute falciparum malaria. Altogether, this work identifies Vγ9Vδ2 T cells as unconventional immune effectors targeting the red blood cell–invasive extracellular P falciparum merozoites and opens novel perspectives for immune interventions harnessing the antiparasitic activity of Vγ9Vδ2 T cells to control parasite density in malaria patients.

scholarly journals γδ+ T Cells Preferentially Respond to Live Rather than Killed Malaria Parasites

1998 ◽  
Vol 66 (5) ◽  
pp. 2393-2398 ◽  
Author(s):  
Martin Waterfall ◽  
Antony Black ◽  
Eleanor Riley
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Peripheral Blood ◽  
Interleukin 2 ◽  
Γδ T Cells ◽  
Feeder Cells ◽  
Parasite Culture ◽  
Recombinant Interleukin 2 ◽  
Culture Supernatants

ABSTRACT We have compared the in vitro responses of peripheral blood T cells from malaria-unexposed donors to live Plasmodium falciparumschizonts, freeze-thawed schizont extracts (P. falciparumschizont extracts [PfSE]), and parasite culture supernatants. We show that the cells responding to PfSE and parasite culture supernatants are predominantly CD4+ TCRαβ+ while in the presence of live schizonts there is an additional activation of TCRγδ+ cells. Activation of TCRγδ+cells in response to PfSE was seen only when irradiated autologous feeder cells or recombinant interleukin-2 (IL-2) was added to the cultures. Live schizonts but not PfSE induced significant IL-2 production in vitro in the first 5 days after stimulation, suggesting that induction of early IL-2 by live parasites may contribute to the marked activation of the TCRγδ+ population.

γδ T cells in the peripheral blood of individuals from an area of holoendemic Plasmodium falciparum transmission

1993 ◽  
Vol 87 (6) ◽  
pp. 692-696 ◽  
Author(s):  
Martin Goodier ◽  
Maria Krause-Jauer ◽  
Ambaliou Sanni ◽  
Achille Massougbodji ◽  
Benoît-Christophe Sadeler ◽  
...  
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Peripheral Blood ◽  
Γδ T Cells
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