scholarly journals γδ-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-γ response to Plasmodium falciparum malaria

2007 ◽  
Vol 37 (7) ◽  
pp. 1864-1873 ◽  
Author(s):  
Marthe C. D'Ombrain ◽  
Diana S. Hansen ◽  
Ken M. Simpson ◽  
Louis Schofield
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Nk Cells ◽  
Falciparum Malaria ◽  
Γδ T Cells ◽  
Plasmodium Falciparum Malaria ◽  
Nk Receptors ◽  
Ifn Γ

Differential re-emergence of αβ and γδ T cells following treatment of acute Plasmodium falciparum malaria

1997 ◽  
Vol 56 ◽  
pp. 423-424
Author(s):  
L. Hvvid ◽  
J.A.L. Kurtzhals ◽  
B. Quam Goka ◽  
C. Behr ◽  
B.D. Akanmori
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Γδ T Cells ◽  
Plasmodium Falciparum Malaria

Subset heterogeneity among γδ T cells found in peripheral blood during Plasmodium falciparum malaria

1992 ◽  
Vol 32 (3) ◽  
pp. 273-274 ◽  
Author(s):  
Wun-Ling Chang ◽  
Henri van der Heyde ◽  
Dennis G. Maki ◽  
Miroslav Malkovsky ◽  
William P. Weidanz
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Peripheral Blood ◽  
Γδ T Cells ◽  
Plasmodium Falciparum Malaria

Increased γδ T cells in acute Plasmodium falciparum malaria

1990 ◽  
Vol 25 (1-3) ◽  
pp. 139-141 ◽  
Author(s):  
May Ho ◽  
H.Kyle Webster ◽  
Pongsri Tongtawe ◽  
Kovit Pattanapanyasat ◽  
William P. Weidanz
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Γδ T Cells ◽  
Plasmodium Falciparum Malaria

scholarly journals Increased Levels of Soluble CD30 in Plasma of Patients with Plasmodium falciparum Malaria

2002 ◽  
Vol 9 (3) ◽  
pp. 720-722
Author(s):  
Kåre Kemp ◽  
Jørgen A. L. Kurtzhals ◽  
Bartholomew D. Akanmori ◽  
Victoria Adabayeri ◽  
Bamenla Q. Goka ◽  
...  
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Gamma Interferon ◽  
Soluble Cd30 ◽  
Peripheral T Cells ◽  
Malaria Attack

ABSTRACT Levels of soluble CD30 (sCD30) in serum were elevated in patients with Plasmodium falciparum malaria but showed decline following treatment. The levels of sCD30 in serum were correlated significantly with the expression of gamma interferon by peripheral T cells. These data suggest that CD30+ cells are upregulated during a malaria attack and that they may play a regulating role at the site of inflammation.

scholarly journals Relationship of regulatory T cells to Plasmodium falciparum malaria symptomatology in a hypoendemic region

2014 ◽  
Vol 13 (1) ◽  
pp. 108 ◽  
Author(s):  
Katherine J Torres ◽  
Elizabeth Villasis ◽  
Jorge Bendezú ◽  
José Chauca ◽  
Joseph M Vinetz ◽  
...  
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Regulatory T Cells ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Relationship Of

scholarly journals Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria

2002 ◽  
Vol 127 (1) ◽  
pp. 151-157 ◽  
Author(s):  
K. Kemp ◽  
B. D. Akanmori ◽  
V. Adabayeri ◽  
B. Q. Goka ◽  
J. A. L. Kurtzhals ◽  
...  
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Cytokine Production ◽  
Plasmodium Falciparum Malaria

scholarly journals Reciprocal Regulation of Th1- and Th2-Cytokine-Producing T Cells during Clearance of Parasitemia in Plasmodium falciparum Malaria

1998 ◽  
Vol 66 (12) ◽  
pp. 6040-6044 ◽  
Author(s):  
Stefan Winkler ◽  
Martin Willheim ◽  
Karin Baier ◽  
Daniela Schmid ◽  
Alexander Aichelburg ◽  
...  
Keyword(s):  
T Cells ◽  
Plasmodium Falciparum ◽  
Interleukin 2 ◽  
Plasmodium Falciparum Malaria ◽  
Parasite Clearance ◽  
Drug Induced ◽  
Reciprocal Regulation ◽  
Th2 Cytokine ◽  
Ifn Γ ◽  
Intracellular Detection

ABSTRACT Flow cytometry for the intracellular detection of T-cell cytokines was performed for 15 Gabonese patients during acute uncomplicatedPlasmodium falciparum malaria. A striking expansion of CD4+ and CD8+ T cells producing gamma interferon (IFN-γ) was found during drug-induced clearance of parasitemia, paralleled by a decrease of interleukin-2 (IL-2) production. The frequency of IL-4- and IL-13-producing CD4+cells gradually decreased, whereas the frequency of T cells producing IL-2+–IFN-γ+, IL-4−–IL-5+, and IL-4+–IL-5+ cytokines as well as IL-4+–IFN-γ+ and IL-13+–IFN-γ+ cytokines was not significantly altered. The capacity for IL-10 production within the CD4+ subset increased due to an expansion of both IL-10+–IFN-γ− and IL-10+–IFN-γ+ cytokine-expressing cells. Thus, a more pronounced Th2-driven immune response during acute untreated P. falciparum infection with a shift towards Th1 responsiveness induced by parasite clearance is suggested.

scholarly journals Contribution of NK, NK T, γδ T, and αβ T Cells to the Gamma Interferon Response Required for Liver Protection against Trypanosoma cruzi

2006 ◽  
Vol 74 (4) ◽  
pp. 2031-2042 ◽  
Author(s):  
Luiz Roberto Sardinha ◽  
Rosa Maria Elias ◽  
Tainá Mosca ◽  
Karina R. B. Bastos ◽  
Cláudio R. F. Marinho ◽  
...  
Keyword(s):  
T Cells ◽  
Trypanosoma Cruzi ◽  
Nk Cells ◽  
Γδ T Cells ◽  
Gamma Interferon ◽  
Cell Populations ◽  
Liver Protection ◽  
Nk T Cells ◽  
Ifn Γ ◽  
Deficient Mice

ABSTRACT In the present work, we show that intracellular Trypanosoma cruzi is rarely found in the livers of acutely infected mice, but inflammation is commonly observed. The presence of numerous intrahepatic amastigotes in infected gamma interferon (IFN-γ)-deficient mice corroborates the notion that the liver is protected by an efficient local immunity. The contribution of different cell populations was suggested by data showing that CD4- and CD8-deficient mice were able to restrain liver parasite growth. Therefore, we have characterized the liver-infiltrating lymphocytes and determined the sources of IFN-γ during acute T. cruzi infection. We observed that natural killer (NK) cells increased by day 7, while T and B cells increased by day 14. Among CD3+ cells, CD4+, CD8+, and CD4− CD8− cell populations were greatly expanded. A large fraction of CD3+ cells were positive for PanNK, a β1 integrin expressed by NK and NK T cells. However, these lymphocytes were not classic NK T cells because they did not express NK1.1 and showed no preferential usage of Vβ8. Otherwise, liver NK T (CD3+ NK1.1+) cells were not increased in acutely infected mice. The majority of PanNK+ CD4+ and PanNK+ CD8+ cells expressed T-cell receptor αβ (TCRαβ), whereas PanNK+ CD4− CD8− cells were positive for TCRγδ. In fact, γδ T cells showed the most remarkable increase (40- to 100-fold) among liver lymphocytes. Most importantly, intracellular analysis revealed high levels of IFN-γ production at day 7 by NK cells and at day 14 by CD4+, CD8+, and CD4− CD8− TCRγδ+ cells. We concluded that NK cells are a precocious source of IFN-γ in the livers of acutely infected mice, and, as the disease progresses, conventional CD4+ and CD8+ T cells and γδ T cells, but not classic NK-T cells, may provide the IFN-γ required for liver protection against T. cruzi.

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