scholarly journals Medroxyprogesterone Acetate Inhibits CD8+T Cell Viral-Specific Effector Function and Induces Herpes Simplex Virus Type 1 Reactivation

2008 ◽  
Vol 181 (2) ◽  
pp. 969-975 ◽  
Author(s):  
Thomas L. Cherpes ◽  
James L. Busch ◽  
Brian S. Sheridan ◽  
Stephen A. K. Harvey ◽  
Robert L. Hendricks
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Medroxyprogesterone Acetate ◽  
Cd8 T Cell ◽  
Specific Effector ◽  
Simplex Virus

scholarly journals Psychological Stress Compromises CD8+T Cell Control of Latent Herpes Simplex Virus Type 1 Infections

2007 ◽  
Vol 179 (1) ◽  
pp. 322-328 ◽  
Author(s):  
Michael L. Freeman ◽  
Brian S. Sheridan ◽  
Robert H. Bonneau ◽  
Robert L. Hendricks
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Psychological Stress ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cd8 T Cell ◽  
Cell Control ◽  
Simplex Virus

scholarly journals Upregulation of Multiple CD8+ T Cell Exhaustion Pathways Is Associated with Recurrent Ocular Herpes Simplex Virus Type 1 Infection

2020 ◽  
Vol 205 (2) ◽  
pp. 454-468
Author(s):  
Pierre-Grégoire Coulon ◽  
Soumyabrata Roy ◽  
Swayam Prakash ◽  
Ruchi Srivastava ◽  
Nisha Dhanushkodi ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cd8 T Cell ◽  
Cell Exhaustion ◽  
Ocular Herpes ◽  
Simplex Virus

scholarly journals Cutting Edge: Priming of CD8 T Cell Immunity to Herpes Simplex Virus Type 1 Requires Cognate TLR3 Expression InVivo

2010 ◽  
Vol 184 (5) ◽  
pp. 2243-2246 ◽  
Author(s):  
Gayle M. Davey ◽  
Magdalena Wojtasiak ◽  
Anna I. Proietto ◽  
Francis R. Carbone ◽  
William R. Heath ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Simplex Virus

Stepwise identification of HLA-A*0201-restricted CD8+ T-cell epitope peptides from herpes simplex virus type 1 genome boosted by a steprank scheme

Biopolymers ◽  
2010 ◽  
Vol 96 (3) ◽  
pp. 328-339 ◽  
Author(s):  
Jianjun Bi ◽  
Rengang Song ◽  
Huilan Yang ◽  
Bingling Li ◽  
Jianyong Fan ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cell Epitope ◽  
Cd8 T Cell ◽  
T Cell Epitope ◽  
Simplex Virus

scholarly journals T Cell Receptor–γ/δ Cells Protect Mice from Herpes Simplex Virus Type 1–induced Lethal Encephalitis

1997 ◽  
Vol 185 (11) ◽  
pp. 1969-1975 ◽  
Author(s):  
Roger Sciammas ◽  
P. Kodukula ◽  
Q. Tang ◽  
R.L. Hendricks ◽  
J.A. Bluestone
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
T Cell Receptor ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cell Receptor ◽  
Simplex Virus ◽  
Hsv 1

Increased numbers of T cell receptor (TCR)-γ/δ cells have been observed in animal models of influenza and sendai virus infections, as well as in patients infected with human immunodeficiency virus and herpes simplex virus type 1 (HSV-1). However, a direct role for TCR-γ/δ cells in protective immunity for pathogenic viral infection has not been demonstrated. To define the role of TCR-γ/δ cells in anti–HSV-1 immunity, TCR-α−/− mice treated with anti– TCR-γ/δ monoclonal antibodies or TCR-γ/δ × TCR-α/β double-deficient mice were infected with HSV-1 by footpad or ocular routes of infection. In both models of HSV-1 infection, TCR-γ/δ cells limited severe HSV-1–induced epithelial lesions and greatly reduced mortality by preventing the development of lethal viral encephalitis. The observed protection resulted from TCR-γ/δ cell–mediated arrest of both viral replication and neurovirulence. The demonstration that TCR-γ/δ cells play an important protective role in murine HSV-1 infections supports their potential contribution to the immune responses in human HSV-1 infection. Thus, this study demonstrates that TCR-γ/δ cells may play an important regulatory role in human HSV-1 infections.

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