scholarly journals T Cell Activation by Coxsackievirus B4 Antigens in Type 1 Diabetes Mellitus: Evidence for Selective TCR Vβ Usage Without Superantigenic Activity

2001 ◽  
Vol 167 (6) ◽  
pp. 3513-3520 ◽  
Author(s):  
Ruben Varela-Calvino ◽  
Gianluca Sgarbi ◽  
Lucy R. Wedderburn ◽  
Colin M. Dayan ◽  
Jenny Tremble ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Type 1 Diabetes Mellitus ◽  
T Cell Activation ◽  
Cell Activation ◽  
Coxsackievirus B4

scholarly journals Caspase-3-Dependent β-Cell Apoptosis in the Initiation of Autoimmune Diabetes Mellitus

2005 ◽  
Vol 25 (9) ◽  
pp. 3620-3629 ◽  
Author(s):  
Nicole Liadis ◽  
Kiichi Murakami ◽  
Mohamed Eweida ◽  
Alisha R. Elford ◽  
Laura Sheu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Apoptosis ◽  
Cell Activation ◽  
Caspase 3 ◽  
Autoimmune Diabetes ◽  
Β Cell

ABSTRACT β-Cell apoptosis is a key event contributing to the pathogenesis of type 1 diabetes mellitus. In addition to apoptosis being the main mechanism by which β cells are destroyed, β-cell apoptosis has been implicated in the initiation of type 1 diabetes mellitus through antigen cross-presentation mechanisms that lead to β-cell-specific T-cell activation. Caspase-3 is the major effector caspase involved in apoptotic pathways. Despite evidence supporting the importance of β-cell apoptosis in the pathogenesis of type 1 diabetes, the specific role of caspase-3 in this process is unknown. Here, we show that Caspase-3 knockout (Casp3 − /−) mice were protected from developing diabetes in a multiple-low-dose streptozotocin autoimmune diabetes model. Lymphocyte infiltration of the pancreatic islets was completely absent in Casp3 − /− mice. To determine the role of caspase-3-dependent apoptosis in disease initiation, a defined antigen-T-cell receptor transgenic system, RIP-GP/P14 double-transgenic mice with Casp3 null mutation, was examined. β-cell antigen-specific T-cell activation and proliferation were observed only in the pancreatic draining lymph node of RIP-GP/P14/Casp3 + /− mice, but not in mice lacking caspase-3. Together, our findings demonstrate that caspase-3-mediated β-cell apoptosis is a requisite step for T-cell priming, a key initiating event in type 1 diabetes.

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

2008 ◽  
Vol 31 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Johanna Aarnisalo ◽  
Andras Treszl ◽  
Peter Svec ◽  
Jane Marttila ◽  
Viveka Öling ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd4 T Cell

scholarly journals Sphingosine-1-Phosphate Reduces CD4+ T-Cell Activation in Type 1 Diabetes Through Regulation of Hypoxia-Inducible Factor Short Isoform I.1 and CD69

Diabetes ◽  
2007 ◽  
Vol 57 (2) ◽  
pp. 484-493 ◽  
Author(s):  
S. Srinivasan ◽  
D. T. Bolick ◽  
D. Lukashev ◽  
C. Lappas ◽  
M. Sitkovsky ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Hypoxia Inducible Factor ◽  
Cd4 T Cell ◽  
Sphingosine 1 Phosphate

scholarly journals CD4+ T cell-dominant insulitis in acute-onset Type 1 diabetes mellitus associated with intraductal papillary mucinous adenoma

2016 ◽  
Vol 63 (9) ◽  
pp. 841-847
Author(s):  
Ken Yajima ◽  
Yoichi Oikawa ◽  
Kentaro Ogata ◽  
Akinori Hashiguchi ◽  
Akira Shimada
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Type 1 Diabetes Mellitus ◽  
Acute Onset ◽  
Onset Type

scholarly journals Polyclonal Anti-T-Cell Therapy for Type 1 Diabetes Mellitus of Recent Onset

2004 ◽  
Vol 1 (2) ◽  
pp. 80-80 ◽  
Author(s):  
Frantisek Saudek ◽  
Tereza Havrdova ◽  
Petr Boucek ◽  
Ludmila Karasova ◽  
Peter Novota ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Cell Therapy ◽  
Type 1 Diabetes Mellitus ◽  
T Cell Therapy ◽  
Recent Onset

Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus

2007 ◽  
Vol 28 (4) ◽  
pp. 177-187 ◽  
Author(s):  
Tihamer Orban ◽  
Janos Kis ◽  
Laszlo Szereday ◽  
Peter Engelmann ◽  
Klara Farkas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Type 1 Diabetes Mellitus ◽  
Cd4 T Cell ◽  
Specific Gene ◽  
Human Type ◽  
Human Type 1 Diabetes

Heparanase prevents the development of type 1 diabetes in non‐obese diabetic mice by regulating T‐cell activation and cytokines production

2008 ◽  
Vol 24 (5) ◽  
pp. 413-421 ◽  
Author(s):  
Menachem Bitan ◽  
Lola Weiss ◽  
Michael Zeira ◽  
Shoshana Reich ◽  
Orit Pappo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Diabetic Mice
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