scholarly journals Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine

2017 ◽  
Vol 199 (4) ◽  
pp. 1319-1332 ◽  
Author(s):  
Kaitlyn Morse ◽  
Yoshifumi Kimizuka ◽  
Megan P. K. Chan ◽  
Mai Shibata ◽  
Yusuke Shimaoka ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Influenza Vaccine ◽  
Near Infrared ◽  
Intradermal Influenza Vaccine

scholarly journals Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine

2014 ◽  
Vol 211 (8) ◽  
pp. 1611-1621 ◽  
Author(s):  
Matthew C. Woodruff ◽  
Balthasar A. Heesters ◽  
Caroline N. Herndon ◽  
Joanna R. Groom ◽  
Paul G. Thomas ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Influenza Vaccine ◽  
Germinal Center ◽  
Viral Antigen ◽  
Specific Antigen ◽  
B Cell Memory ◽  
Antigen Presenting ◽  
Effective Immunization ◽  
Collection Sites

Dendritic cells (DCs) are well established as potent antigen-presenting cells critical to adaptive immunity. In vaccination approaches, appropriately stimulating lymph node–resident DCs (LNDCs) is highly relevant to effective immunization. Although LNDCs have been implicated in immune response, their ability to directly drive effective immunity to lymph-borne antigen remains unclear. Using an inactive influenza vaccine model and whole node imaging approaches, we observed surprising responsiveness of LNDC populations to vaccine arrival resulting in a transnodal repositioning into specific antigen collection sites within minutes after immunization. Once there, LNDCs acquired viral antigen and initiated activation of viral specific CD4+ T cells, resulting in germinal center formation and B cell memory in the absence of skin migratory DCs. Together, these results demonstrate an unexpected stimulatory role for LNDCs where they are capable of rapidly locating viral antigen, driving early activation of T cell populations, and independently establishing functional immune response.

The Inducing Roles of the New Isolated Bursal Hexapeptide and Pentapeptide on the Immune Response of AIV Vaccine in Mice

2019 ◽  
Vol 26 (7) ◽  
pp. 542-549 ◽  
Author(s):  
Shan Shan Hao ◽  
Man Man Zong ◽  
Ze Zhang ◽  
Jia Xi Cai ◽  
Yang Zheng ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Amino Acid ◽  
T Cell ◽  
Antigen Presentation ◽  
Amino Acid Sequences ◽  
Cell Subpopulation ◽  
Igg Antibody ◽  
Antibody Titers ◽  
Specific Igg

Background: Bursa of Fabricius is the acknowledged central humoral immune organ. The bursal-derived peptides play the important roles on the immature B cell development and antibody production. Objective: Here we explored the functions of the new isolated bursal hexapeptide and pentapeptide on the humoral, cellular immune response and antigen presentation to Avian Influenza Virus (AIV) vaccine in mice immunization. Methods: The bursa extract samples were purified following RP HPLC method, and were analyzed with MS/MS to identify the amino acid sequences. Mice were twice subcutaneously injected with AIV inactivated vaccine plus with two new isolated bursal peptides at three dosages, respectively. On two weeks after the second immunization, sera samples were collected from the immunized mice to measure AIV-specific IgG antibody levels and HI antibody titers. Also, on 7th day after the second immunization, lymphocytes were isolated from the immunized mice to detect T cell subtype and lymphocyte viabilities, and the expressions of co-stimulatory molecule on dendritic cells in the immunized mice. Results: Two new bursal hexapeptide and pentapeptide with amino acid sequences KGNRVY and MPPTH were isolated, respectively. Our investigation proved the strong regulatory roles of bursal hexapeptide on AIV-specific IgG levels and HI antibody titers, and lymphocyte viabilities, and the significant increased T cells subpopulation and expressions of MHCII molecule on dendritic cells in the immunized mice. Moreover, our findings verified the significantly enhanced AIV-specific IgG antibody and HI titers, and the strong increased T cell subpopulation and expressions of CD40 molecule on dendritic cells in the mice immunized with AIV vaccine and bursal pentapeptide. Conclusion: We isolated and identified two new hexapeptide and pentapeptide from bursa, and proved that these two bursal peptides effectively induced the AIV-specific antibody, T cell and antigen presentation immune responses, which provided an experimental basis for the further clinical application of the bursal derived active peptide on the vaccine improvement.

Aggregate content influences the Th1/Th2 immune response to influenza vaccine: Evidence from a mouse model

2003 ◽  
Vol 72 (1) ◽  
pp. 138-142 ◽  
Author(s):  
Shawn Babiuk ◽  
Danuta M. Skowronski ◽  
Gaston De Serres ◽  
Kent HayGlass ◽  
Robert C. Brunham ◽  
...  
Keyword(s):  
Immune Response ◽  
Mouse Model ◽  
Influenza Vaccine ◽  
Aggregate Content ◽  
Th2 Immune Response

scholarly journals Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0223991
Author(s):  
Carole Nagant ◽  
Cyril Barbezange ◽  
Laurence Dedeken ◽  
Tatiana Besse-Hammer ◽  
Isabelle Thomas ◽  
...  
Keyword(s):  
Immune Response ◽  
Sickle Cell Disease ◽  
Influenza Vaccine ◽  
Sickle Cell ◽  
Cell Disease

scholarly journals Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Melanie R. Neeland ◽  
Samantha Bannister ◽  
Vanessa Clifford ◽  
Kate Dohle ◽  
Kim Mulholland ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Immune Responses ◽  
Acute Phase ◽  
Innate Immune ◽  
Low Density ◽  
Innate Immune Responses ◽  
Immunological Mechanisms ◽  
Activated Neutrophils ◽  
Classical Monocytes

AbstractChildren have mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed disease (COVID-19) compared to adults and the immunological mechanisms underlying this difference remain unclear. Here, we report acute and convalescent innate immune responses in 48 children and 70 adults infected with, or exposed to, SARS-CoV-2. We find clinically mild SARS-CoV-2 infection in children is characterised by reduced circulating subsets of monocytes (classical, intermediate, non-classical), dendritic cells and natural killer cells during the acute phase. In contrast, SARS-CoV-2-infected adults show reduced proportions of non-classical monocytes only. We also observe increased proportions of CD63+ activated neutrophils during the acute phase to SARS-CoV-2 in infected children. Children and adults exposed to SARS-CoV-2 but negative on PCR testing display increased proportions of low-density neutrophils that we observe up to 7 weeks post exposure. This study characterises the innate immune response during SARS-CoV-2 infection and household exposure in children.

scholarly journals Murine Myeloid Dendritic Cells That Phagocytose Apoptotic T Cells Inhibit the Immune Response via NO

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49378 ◽  
Author(s):  
Kaili Zhong ◽  
Wengang Song ◽  
Qian Wang ◽  
Chao Wang ◽  
Xi Liu ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Dendritic Cells ◽  
Myeloid Dendritic Cells
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