scholarly journals Anti-Inflammatory or Proinflammatory Effect of an Adenosine Receptor Agonist on the Th17 Autoimmune Response Is Inflammatory Environment–Dependent

2014 ◽  
Vol 193 (11) ◽  
pp. 5498-5505 ◽  
Author(s):  
Dongchun Liang ◽  
Aijun Zuo ◽  
Hui Shao ◽  
Mingjiazi Chen ◽  
Henry J. Kaplan ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Receptor Agonist ◽  
Autoimmune Response ◽  
Adenosine Receptor Agonist ◽  
Proinflammatory Effect ◽  
Anti Inflammatory

scholarly journals CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver

2011 ◽  
Vol 226 (9) ◽  
pp. 2438-2447 ◽  
Author(s):  
S. Cohen ◽  
S.M. Stemmer ◽  
G. Zozulya ◽  
A. Ochaion ◽  
R. Patoka ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Receptor Agonist ◽  
Adenosine Receptor Agonist ◽  
A3 Adenosine Receptor ◽  
Anti Inflammatory

scholarly journals Voltage-sensitive dye delivery through the blood brain barrier using adenosine receptor agonist regadenoson

2018 ◽  
Vol 9 (8) ◽  
pp. 3915 ◽  
Author(s):  
Rebecca W. Pak ◽  
Jeeun Kang ◽  
Heather Valentine ◽  
Leslie M. Loew ◽  
Daniel L. J. Thorek ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Adenosine Receptor ◽  
Receptor Agonist ◽  
Brain Barrier ◽  
Voltage Sensitive Dye ◽  
Blood Brain ◽  
Adenosine Receptor Agonist

A3 Adenosine Receptor Agonist Inhibited Survival of Breast Cancer Stem Cells via GLI-1 and ERK1/2 Pathway

2017 ◽  
Vol 118 (9) ◽  
pp. 2909-2920 ◽  
Author(s):  
Seyyed Mehdi Jafari ◽  
Mojtaba Panjehpour ◽  
Mahmoud Aghaei ◽  
Hamid Reza Joshaghani ◽  
Seyed Ehsan Enderami
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Adenosine Receptor ◽  
Receptor Agonist ◽  
Breast Cancer Stem Cells ◽  
Adenosine Receptor Agonist ◽  
A3 Adenosine Receptor ◽  
Gli 1

Evidence for regulated coupling of A1 adenosine receptors by phosphorylation in Zucker rats

1995 ◽  
Vol 268 (4) ◽  
pp. E693-E704 ◽  
Author(s):  
D. A. Berkich ◽  
D. R. Luthin ◽  
R. L. Woodard ◽  
S. J. Vannucci ◽  
J. Linden ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Adenosine Receptors ◽  
Receptor Agonist ◽  
High Sensitivity ◽  
Zucker Rats ◽  
Guanine Nucleotide ◽  
Agonist Binding ◽  
A1 Adenosine Receptor ◽  
Adenosine Receptor Agonist ◽  
A1 Adenosine Receptors

Studies were designed to find the molecular basis for previous observations that lipolysis is less active and A1 adenosine receptor signaling is more active in adipocytes from obese than from lean Zucker rats. With quantitative immunoblot procedures for detection, Gi alpha 1 and Gs alpha 45 levels were found anomalously low in obese compared with lean membranes (50 and 30%, respectively), but other G alpha subunit levels were normal. However, the sensitivity of the receptor-Gi protein to GTP was about 5- to 10-fold higher in obese compared with lean membranes when assessed from 1) the ability of GTP to inhibit forskolin-stimulated adenylyl cyclase in the presence of an adenosine receptor agonist and 2) the ability of a nonhydrolyzable guanine nucleotide analogue to alter A1 adenosine receptor agonist binding. Alkaline phosphatase treatment of isolated adipocyte membranes from obese but not lean animals decreased guanine nucleotide sensitivity of agonist binding. Surprisingly, solubilized adipocyte A1 adenosine receptors from all animals exhibited the same high sensitivity to guanine nucleotides as that of intact obese membranes, and this high sensitivity could be decreased 20-fold by treatment with alkaline phosphatase. These data suggest that protein phosphorylation may regulate coupling of the A1 adenosine receptor in rat adipocyte membranes.

scholarly journals Discovery of A New Human A2A Adenosine Receptor Agonist, Truncated 2-Hexynyl-4′-thioadenosine

2010 ◽  
Vol 1 (9) ◽  
pp. 516-520 ◽  
Author(s):  
Xiyan Hou ◽  
Hea Ok Kim ◽  
Varughese Alexander ◽  
Kyunglim Kim ◽  
Sun Choi ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Receptor Agonist ◽  
A2a Adenosine Receptor ◽  
Adenosine Receptor Agonist
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