Discovery of A New Human A2A Adenosine Receptor Agonist, Truncated 2-Hexynyl-4′-thioadenosine

Xiyan Hou; Hea Ok Kim; Varughese Alexander; Kyunglim Kim; Sun Choi; Seul-gi Park; Jin Hee Lee; Lena S. Yoo; Zhan-Guo Gao; Kenneth A. Jacobson; Lak Shin Jeong

doi:10.1021/ml1001823

Discovery of A New Human A2A Adenosine Receptor Agonist, Truncated 2-Hexynyl-4′-thioadenosine

ACS Medicinal Chemistry Letters ◽

10.1021/ml1001823 ◽

2010 ◽

Vol 1 (9) ◽

pp. 516-520 ◽

Cited By ~ 13

Author(s):

Xiyan Hou ◽

Hea Ok Kim ◽

Varughese Alexander ◽

Kyunglim Kim ◽

Sun Choi ◽

...

Keyword(s):

Adenosine Receptor ◽

Receptor Agonist ◽

A2a Adenosine Receptor ◽

Adenosine Receptor Agonist

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Effects of CGS 21680, a selective A2A adenosine receptor agonist, on cardiac output and vascular resistance in acute heart failure in the anaesthetized rat

British Journal of Pharmacology ◽

10.1038/sj.bjp.0701764 ◽

1998 ◽

Vol 123 (8) ◽

pp. 1666-1672 ◽

Cited By ~ 10

Author(s):

Ali A. Nekooeian ◽

Reza Tabrizchi

Keyword(s):

Heart Failure ◽

Cardiac Output ◽

Acute Heart Failure ◽

Vascular Resistance ◽

Adenosine Receptor ◽

Receptor Agonist ◽

A2a Adenosine Receptor ◽

Cgs 21680 ◽

Adenosine Receptor Agonist ◽

Anaesthetized Rat

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8.22Receptor reserve is large for coronary hyperemia induced by regadenoson, a moderate affinity A2a-adenosine receptor agonist and vasodilator for cardiac perfusion imaging

Journal of Nuclear Cardiology ◽

10.1016/j.nuclcard.2006.12.249 ◽

2007 ◽

Vol 14 (2) ◽

pp. S63-S63 ◽

Cited By ~ 2

Author(s):

J SHRYOCK ◽

Y WU

Keyword(s):

Perfusion Imaging ◽

Adenosine Receptor ◽

Receptor Agonist ◽

Cardiac Perfusion ◽

A2a Adenosine Receptor ◽

Adenosine Receptor Agonist

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Excitatory effect of the A2A adenosine receptor agonist CGS-21680 on spontaneous and K+-evoked acetylcholine release at the mouse neuromuscular junction

Neuroscience ◽

10.1016/j.neuroscience.2010.10.015 ◽

2011 ◽

Vol 172 ◽

pp. 164-176 ◽

Cited By ~ 5

Author(s):

A.G. Palma ◽

S. Muchnik ◽

A.S. Losavio

Keyword(s):

Neuromuscular Junction ◽

Adenosine Receptor ◽

Receptor Agonist ◽

Acetylcholine Release ◽

Excitatory Effect ◽

A2a Adenosine Receptor ◽

Cgs 21680 ◽

Adenosine Receptor Agonist

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A population pharmacokinetic/pharmacodynamic analysis of regadenoson, an A2A adenosine receptor agonist, in healthy subjects

Journal of Nuclear Cardiology ◽

10.1016/j.nuclcard.2004.12.250 ◽

2005 ◽

Vol 12 (2) ◽

pp. S74-S74

Author(s):

T GORDI ◽

A OLMSTED ◽

H LIEU ◽

L BELARDINELLI

Keyword(s):

Adenosine Receptor ◽

Healthy Subjects ◽

Receptor Agonist ◽

Population Pharmacokinetic ◽

A2a Adenosine Receptor ◽

Adenosine Receptor Agonist ◽

Pharmacodynamic Analysis

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The impact of adenosine and an A2A adenosine receptor agonist on the ACh-induced increase in intracellular calcium of the glomus cells of the cat carotid body

Brain Research ◽

10.1016/j.brainres.2009.08.100 ◽

2009 ◽

Vol 1301 ◽

pp. 20-33 ◽

Cited By ~ 7

Author(s):

Robert S. Fitzgerald ◽

Machiko Shirahata ◽

Irene Chang

Keyword(s):

Intracellular Calcium ◽

Carotid Body ◽

Adenosine Receptor ◽

Receptor Agonist ◽

A2a Adenosine Receptor ◽

Glomus Cells ◽

Adenosine Receptor Agonist ◽

The Impact

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A population pharmacokinetic/pharmacodynamic analysis of regadenoson, an A2A adenosine receptor agonist, suggests unit-based dosing in humans

Journal of Nuclear Cardiology ◽

10.1016/j.nuclcard.2004.12.251 ◽

2005 ◽

Vol 12 (2) ◽

pp. S74-S74

Author(s):

T GORDI ◽

H LIEU ◽

A OLMSTED ◽

L BELARDINELLI

Keyword(s):

Adenosine Receptor ◽

Receptor Agonist ◽

Population Pharmacokinetic ◽

A2a Adenosine Receptor ◽

Adenosine Receptor Agonist ◽

Pharmacodynamic Analysis

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The Effect of A2A Adenosine Receptor Agonist on Composite Tissue Allotransplant Survival: An In Vivo Preliminary Study

Journal of Surgical Research ◽

10.1016/j.jss.2005.12.016 ◽

2006 ◽

Vol 131 (2) ◽

pp. 261-266 ◽

Cited By ~ 4

Author(s):

Betul Gozel Ulusal ◽

Ali Engin Ulusal ◽

Li-Man Hung ◽

Fu-Chan Wei

Keyword(s):

Adenosine Receptor ◽

Receptor Agonist ◽

A2a Adenosine Receptor ◽

Composite Tissue ◽

Adenosine Receptor Agonist ◽

Preliminary Study

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Myocardial perfusion imaging with a novel selective A2a adenosine receptor agonist (CVT-3146): Important differences in radiotracer behavior

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(03)81346-3 ◽

2003 ◽

Vol 41 (6) ◽

pp. 443-444

Author(s):

Farid Jadbabaie ◽

David F. Meoli ◽

Brian N. Bourke ◽

Kailasnath Purushothaman ◽

Lori Brown ◽

...

Keyword(s):

Myocardial Perfusion Imaging ◽

Myocardial Perfusion ◽

Perfusion Imaging ◽

Adenosine Receptor ◽

Receptor Agonist ◽

A2a Adenosine Receptor ◽

Adenosine Receptor Agonist

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Pharmacokinetic modelling of the haemodynamic effects of the A2a adenosine receptor agonist CGS 21680C in conscious normotensive rats

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1995.tb13270.x ◽

1995 ◽

Vol 114 (4) ◽

pp. 761-768 ◽

Cited By ~ 17

Author(s):

R.A.A. Mathôt ◽

A. Cleton ◽

W. Soudijn ◽

A.P. IJzerman ◽

M. Danhof

Keyword(s):

Adenosine Receptor ◽

Receptor Agonist ◽

Haemodynamic Effects ◽

Pharmacokinetic Modelling ◽

A2a Adenosine Receptor ◽

Adenosine Receptor Agonist

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Effects of a new selective A2a adenosine receptor agonist on Thallium-201 and Tcm99-MIBI biodistribution and clearance: Implications for optimizing vasodilator stress perfusion imaging

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(03)82547-0 ◽

2003 ◽

Vol 41 (6) ◽

pp. 461

Author(s):

Farid Jadbabaie ◽

David F. Meoli ◽

Brian N. Bourke ◽

Kailasnath Purushothaman ◽

Stacy Sullivan ◽

...

Keyword(s):

Perfusion Imaging ◽

Adenosine Receptor ◽

Receptor Agonist ◽

Thallium 201 ◽

Vasodilator Stress ◽

Stress Perfusion ◽

A2a Adenosine Receptor ◽

Stress Perfusion Imaging ◽

Adenosine Receptor Agonist

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