scholarly journals Fungal β-Glucan, a Dectin-1 Ligand, Promotes Protection from Type 1 Diabetes by Inducing Regulatory Innate Immune Response

2014 ◽  
Vol 193 (7) ◽  
pp. 3308-3321 ◽  
Author(s):  
Subha Karumuthil-Melethil ◽  
Radhika Gudi ◽  
Benjamin M. Johnson ◽  
Nicolas Perez ◽  
Chenthamarakshan Vasu
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Innate Immune Response ◽  
Innate Immune

scholarly journals Induction of Innate Immune Response through TLR2 and Dectin 1 Prevents Type 1 Diabetes

2008 ◽  
Vol 181 (12) ◽  
pp. 8323-8334 ◽  
Author(s):  
Subha Karumuthil-Melethil ◽  
Nicolas Perez ◽  
Ruobing Li ◽  
Chenthamarakshan Vasu
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Innate Immune Response ◽  
Innate Immune

scholarly journals Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes

2003 ◽  
Vol 33 (5) ◽  
pp. 1439-1449 ◽  
Author(s):  
Paola Zaccone ◽  
Zoltán Fehérvári ◽  
Frances M. Jones ◽  
Stéphane Sidobre ◽  
Mitchell Kronenberg ◽  
...  
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Schistosoma Mansoni ◽  
Innate Immune Response ◽  
Innate Immune

scholarly journals TLR2- and Dectin 1–Associated Innate Immune Response Modulates T-Cell Response to Pancreatic β-Cell Antigen and Prevents Type 1 Diabetes

Diabetes ◽  
2014 ◽  
Vol 64 (4) ◽  
pp. 1341-1357 ◽  
Author(s):  
Subha Karumuthil-Melethil ◽  
M. Hanief Sofi ◽  
Radhika Gudi ◽  
Benjamin M. Johnson ◽  
Nicolas Perez ◽  
...  
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Innate Immune Response ◽  
Cell Response ◽  
T Cell Response ◽  
Innate Immune ◽  
Pancreatic Β Cell ◽  
Β Cell

scholarly journals TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

Diabetes ◽  
2015 ◽  
Vol 64 (11) ◽  
pp. 3808-3817 ◽  
Author(s):  
Laura Marroqui ◽  
Reinaldo Sousa Dos Santos ◽  
Tina Fløyel ◽  
Fabio A. Grieco ◽  
Izortze Santin ◽  
...  
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Candidate Gene ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Β Cells ◽  
Pancreatic Β Cells

scholarly journals Human Immunodeficiency Virus Type 1 Infection Induces Cyclin T1 Expression in Macrophages

2004 ◽  
Vol 78 (15) ◽  
pp. 8114-8119 ◽  
Author(s):  
Li-Ying Liou ◽  
Christine H. Herrmann ◽  
Andrew P. Rice
Keyword(s):  
Immune Response ◽  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Innate Immune Response ◽  
Virus Type ◽  
Innate Immune ◽  
Cyclin T1 ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT The Tat protein of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication and activates RNA polymerase II transcriptional elongation through the association with a cellular protein kinase composed of Cdk9 and cyclin T1. Tat binds to this kinase complex through a direct protein-protein interaction with cyclin T1. Monocytes/macrophages are important targets of HIV-1 infection, and previous work has shown that cyclin T1 but not Cdk9 protein expression is low in monocytes isolated from blood. While Cdk9 expression is expressed at a high level during monocyte differentiation to macrophages in vitro, cyclin T1 expression is induced during the first few days of differentiation and is shut off after 1 to 2 weeks. We show here that the shutoff of cyclin T1 expression in late-differentiated macrophages involves proteasome-mediated proteolysis. We also show that cyclin T1 can be reinduced by a number of pathogen-associated molecular patterns that activate macrophages, indicating that up-regulation of cyclin T1 is part of an innate immune response. Furthermore, we found that HIV-1 infection early in macrophage differentiation results in sustained cyclin T1 expression, while infection at late times in differentiation results in the reinduction of cyclin T1. Expression of the viral Nef protein from an adenovirus vector suggests that Nef contributes to the HIV-1 induction of cyclin T1. These findings suggest that HIV-1 infection hijacks a component of the innate immune response in macrophages that results in enhancement rather than inhibition of viral replication.

scholarly journals Lyssavirus infection activates interferon gene expression in the brain

2006 ◽  
Vol 87 (9) ◽  
pp. 2663-2667 ◽  
Author(s):  
Nicholas Johnson ◽  
Clive S. McKimmie ◽  
Karen L. Mansfield ◽  
Philip R. Wakeley ◽  
Sharon M. Brookes ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Mammalian Species ◽  
Innate Immune ◽  
Antiviral Protein ◽  
Zoonotic Viruses ◽  
Mouse Model System ◽  
The Brain ◽  
Interferon Gene

To investigate the innate immune response within the brain to lyssavirus infection, key transcripts indicative of innate defences were measured in a mouse model system. Following infection with Rabies virus, transcript levels for type 1 interferons (IFN-α and -β), the inflammatory mediator interleukin 6 (IL-6) and the antiviral protein Mx1 increased in the brains of mice. Intracranial inoculation resulted in the early detection of virus replication and rapid expression within the brain of the innate immune response genes. Transcripts for type 1 IFNs declined as the disease progressed. Peripheral, extraneural inoculation delayed the host response until virus entered the brain, but then resulted in a large increase in the level of IFN-β, IL-6 and Mx1 transcripts. Induction of this response was also observed following infection with the related European bat lyssaviruses, a group of zoonotic viruses capable of causing fatal, rabies-like disease in mammalian species.

scholarly journals Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataracts

2011 ◽  
Vol 21 (4) ◽  
pp. 852-862 ◽  
Author(s):  
Jeremy D. Rhodes ◽  
Martin C. Lott ◽  
Sarah L. Russell ◽  
Vincent Moulton ◽  
Julie Sanderson ◽  
...  
Keyword(s):  
Immune Response ◽  
Myotonic Dystrophy ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Myotonic Dystrophy Type 1 ◽  
Myotonic Dystrophy Type ◽  
Interferon Signalling
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