scholarly journals TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

Diabetes ◽  
2015 ◽  
Vol 64 (11) ◽  
pp. 3808-3817 ◽  
Author(s):  
Laura Marroqui ◽  
Reinaldo Sousa Dos Santos ◽  
Tina Fløyel ◽  
Fabio A. Grieco ◽  
Izortze Santin ◽  
...  
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Candidate Gene ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Β Cells ◽  
Pancreatic Β Cells

scholarly journals Induction of Innate Immune Response through TLR2 and Dectin 1 Prevents Type 1 Diabetes

2008 ◽  
Vol 181 (12) ◽  
pp. 8323-8334 ◽  
Author(s):  
Subha Karumuthil-Melethil ◽  
Nicolas Perez ◽  
Ruobing Li ◽  
Chenthamarakshan Vasu
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Innate Immune Response ◽  
Innate Immune

scholarly journals Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes

2003 ◽  
Vol 33 (5) ◽  
pp. 1439-1449 ◽  
Author(s):  
Paola Zaccone ◽  
Zoltán Fehérvári ◽  
Frances M. Jones ◽  
Stéphane Sidobre ◽  
Mitchell Kronenberg ◽  
...  
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Schistosoma Mansoni ◽  
Innate Immune Response ◽  
Innate Immune

scholarly journals Fungal β-Glucan, a Dectin-1 Ligand, Promotes Protection from Type 1 Diabetes by Inducing Regulatory Innate Immune Response

2014 ◽  
Vol 193 (7) ◽  
pp. 3308-3321 ◽  
Author(s):  
Subha Karumuthil-Melethil ◽  
Radhika Gudi ◽  
Benjamin M. Johnson ◽  
Nicolas Perez ◽  
Chenthamarakshan Vasu
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Innate Immune Response ◽  
Innate Immune

scholarly journals TLR2- and Dectin 1–Associated Innate Immune Response Modulates T-Cell Response to Pancreatic β-Cell Antigen and Prevents Type 1 Diabetes

Diabetes ◽  
2014 ◽  
Vol 64 (4) ◽  
pp. 1341-1357 ◽  
Author(s):  
Subha Karumuthil-Melethil ◽  
M. Hanief Sofi ◽  
Radhika Gudi ◽  
Benjamin M. Johnson ◽  
Nicolas Perez ◽  
...  
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Innate Immune Response ◽  
Cell Response ◽  
T Cell Response ◽  
Innate Immune ◽  
Pancreatic Β Cell ◽  
Β Cell

Formation of pancreatic β-cells from precursor cells contributes to the reversal of established type 1 diabetes

2021 ◽  
pp. 104360
Author(s):  
Tobechukwu K. Ukah ◽  
Alexis N. Cattin-Roy ◽  
George E. Davis ◽  
Habib Zaghouani
Keyword(s):  
Type 1 Diabetes ◽  
Precursor Cells ◽  
Β Cells ◽  
Pancreatic Β Cells

scholarly journals Nonlinear Analysis for a Type-1 Diabetes Model with Focus on T-Cells and Pancreatic β-Cells Behavior

2020 ◽  
Vol 25 (2) ◽  
pp. 23
Author(s):  
Diana Gamboa ◽  
Carlos E. Vázquez ◽  
Paul J. Campos
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cell Population ◽  
Closed Loop ◽  
Pancreatic Β Cell ◽  
Activated Macrophages ◽  
Β Cells ◽  
Β Cell ◽  
Pancreatic Β Cells

Type-1 diabetes mellitus (T1DM) is an autoimmune disease that has an impact on mortality due to the destruction of insulin-producing pancreatic β -cells in the islets of Langerhans. Over the past few years, the interest in analyzing this type of disease, either in a biological or mathematical sense, has relied on the search for a treatment that guarantees full control of glucose levels. Mathematical models inspired by natural phenomena, are proposed under the prey–predator scheme. T1DM fits in this scheme due to the complicated relationship between pancreatic β -cell population growth and leukocyte population growth via the immune response. In this scenario, β -cells represent the prey, and leukocytes the predator. This paper studies the global dynamics of T1DM reported by Magombedze et al. in 2010. This model describes the interaction of resting macrophages, activated macrophages, antigen cells, autolytic T-cells, and β -cells. Therefore, the localization of compact invariant sets is applied to provide a bounded positive invariant domain in which one can ensure that once the dynamics of the T1DM enter into this domain, they will remain bounded with a maximum and minimum value. Furthermore, we analyzed this model in a closed-loop scenario based on nonlinear control theory, and proposed bases for possible control inputs, complementing the model with them. These entries are based on the existing relationship between cell–cell interaction and the role that they play in the unchaining of a diabetic condition. The closed-loop analysis aims to give a deeper understanding of the impact of autolytic T-cells and the nature of the β -cell population interaction with the innate immune system response. This analysis strengthens the proposal, providing a system free of this illness—that is, a condition wherein the pancreatic β -cell population holds and there are no antigen cells labeled by the activated macrophages.

scholarly journals Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity, and Ameliorates Type 1 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (8) ◽  
pp. 1692-1707
Author(s):  
Geming Lu ◽  
Francisco Rausell-Palamos ◽  
Jiamin Zhang ◽  
Zihan Zheng ◽  
Tuo Zhang ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Dextran Sulfate ◽  
Β Cells ◽  
Pancreatic Β Cells
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