scholarly journals HIV-1 gp120 Impairs the Induction of B Cell Responses by TLR9-Activated Plasmacytoid Dendritic Cells

2012 ◽  
Vol 189 (11) ◽  
pp. 5257-5265 ◽  
Author(s):  
Nancy P. Y. Chung ◽  
Katie Matthews ◽  
Per Johan Klasse ◽  
Rogier W. Sanders ◽  
John P. Moore
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Responses ◽  
B Cell Responses ◽  
Hiv 1

scholarly journals Plasmacytoid dendritic cells promote rotavirus-induced human and murine B cell responses

2013 ◽  
Vol 123 (6) ◽  
pp. 2464-2474 ◽  
Author(s):  
Emily M. Deal ◽  
Katharina Lahl ◽  
Carlos F. Narváez ◽  
Eugene C. Butcher ◽  
Harry B. Greenberg
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Responses ◽  
B Cell Responses

scholarly journals Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells

2009 ◽  
Vol 182 (4) ◽  
pp. 1991-2001 ◽  
Author(s):  
Iyadh Douagi ◽  
Cornelia Gujer ◽  
Christopher Sundling ◽  
William C. Adams ◽  
Anna Smed-Sörensen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Responses ◽  
B Cell Responses ◽  
Human B Cell

scholarly journals Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA

Immunity ◽  
2020 ◽  
Vol 52 (6) ◽  
pp. 1022-1038.e7 ◽  
Author(s):  
Chetna Soni ◽  
Oriana A. Perez ◽  
William N. Voss ◽  
Joseph N. Pucella ◽  
Lee Serpas ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Type I Interferon ◽  
Plasmacytoid Dendritic Cells ◽  
Type I ◽  
Cell Responses ◽  
B Cell Responses

scholarly journals Human Cytomegalovirus Differentially Controls B Cell and T Cell Responses through Effects on Plasmacytoid Dendritic Cells

2007 ◽  
Vol 179 (11) ◽  
pp. 7767-7776 ◽  
Author(s):  
Stefania Varani ◽  
Madeleine Cederarv ◽  
Sari Feld ◽  
Charlotte Tammik ◽  
Giada Frascaroli ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
B Cell ◽  
Human Cytomegalovirus ◽  
T Cell Responses ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Responses

scholarly journals Clinical Adjuvant Combinations Stimulate Potent B-Cell Responses In Vitro by Activating Dermal Dendritic Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63785 ◽  
Author(s):  
Katie Matthews ◽  
Nancy P. Y. Chung ◽  
Per Johan Klasse ◽  
Magda Moutaftsi ◽  
Darrick Carter ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Cell Responses ◽  
B Cell Responses

scholarly journals Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys

2015 ◽  
Vol 89 (18) ◽  
pp. 9485-9498 ◽  
Author(s):  
Joshua D. Amos ◽  
Jonathon E. Himes ◽  
Lawrence Armand ◽  
Thaddeus C. Gurley ◽  
David R. Martinez ◽  
...  
Keyword(s):  
B Cell ◽  
Disease Progression ◽  
Simian Immunodeficiency Virus ◽  
Rapid Development ◽  
Virus Transmission ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Siv Infection ◽  
B Cell Responses ◽  
Hiv 1

ABSTRACTThe initial phases of acute human immunodeficiency virus type 1 (HIV-1) infection may be critical for development of effective envelope (Env)-specific antibodies capable of impeding the establishment of the latent pool of HIV-1-infected CD4+T cells, preventing virus-induced immune hyperactivation to limit disease progression and blocking vertical virus transmission. However, the initial systemic HIV-1 Env-specific antibody response targets gp41 epitopes and fails to control acute-phase viremia. African-origin, natural simian immunodeficiency virus (SIV) hosts do not typically progress to AIDS and rarely postnatally transmit virus to their infants, despite high milk viral loads. Conversely, SIV-infected rhesus macaques (RMs), Asian-origin nonnatural SIV hosts, sustain pathogenic SIV infections and exhibit higher rates of postnatal virus transmission. In this study, of acute SIV infection, we compared the initial systemic Env-specific B cell responses of AGMs and RMs in order to probe potential factors influencing the lack of disease progression observed in AGMs. AGMs developed higher-magnitude plasma gp120-specific IgA and IgG responses than RMs, whereas RMs developed more robust gp140-directed IgG responses. These gp120-focused antibody responses were accompanied by rapid autologous neutralizing responses during acute SIV infection in AGMs compared to RMs. Moreover, acute SIV infection elicited a higher number of circulating Env-specific memory B cells in peripheral blood of AGMs than in the blood of RMs. These findings indicate that AGMs have initial systemic Env-specific B cell responses to SIV infection distinct from those of a nonnatural SIV host, resulting in more functional SIV-specific humoral responses, which may be involved in impairing pathogenic disease progression and minimizing postnatal transmission.IMPORTANCEDue to the worldwide prevalence of HIV-1 infections, development of a vaccine to prevent infection or limit the viral reservoir remains an important goal. HIV-1-infected humans, as well as SIV-infected nonnatural SIV hosts, develop pathogenic infections and readily transmit the virus to their infants. Conversely, natural SIV hosts do not develop pathogenic infections and rarely transmit the virus to their infants. The immunologic factors contributing to these favorable outcomes in natural SIV hosts could prove invaluable for directing HIV-1 vaccine and therapy design. This study identified distinctions in the specificity and function of the initial systemic SIV envelope-specific B cell response that developed during acute SIV infection in natural and nonnatural SIV host species. Identification of distinct acute B cell responses in natural SIV hosts may inform vaccine strategies seeking to elicit similar responses prior to or during the initial phases of acute HIV-1 infection.

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