scholarly journals Plasmacytoid dendritic cells promote rotavirus-induced human and murine B cell responses

2013 ◽  
Vol 123 (6) ◽  
pp. 2464-2474 ◽  
Author(s):  
Emily M. Deal ◽  
Katharina Lahl ◽  
Carlos F. Narváez ◽  
Eugene C. Butcher ◽  
Harry B. Greenberg
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Responses ◽  
B Cell Responses

scholarly journals HIV-1 gp120 Impairs the Induction of B Cell Responses by TLR9-Activated Plasmacytoid Dendritic Cells

2012 ◽  
Vol 189 (11) ◽  
pp. 5257-5265 ◽  
Author(s):  
Nancy P. Y. Chung ◽  
Katie Matthews ◽  
Per Johan Klasse ◽  
Rogier W. Sanders ◽  
John P. Moore
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Responses ◽  
B Cell Responses ◽  
Hiv 1

scholarly journals Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells

2009 ◽  
Vol 182 (4) ◽  
pp. 1991-2001 ◽  
Author(s):  
Iyadh Douagi ◽  
Cornelia Gujer ◽  
Christopher Sundling ◽  
William C. Adams ◽  
Anna Smed-Sörensen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Responses ◽  
B Cell Responses ◽  
Human B Cell

scholarly journals Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA

Immunity ◽  
2020 ◽  
Vol 52 (6) ◽  
pp. 1022-1038.e7 ◽  
Author(s):  
Chetna Soni ◽  
Oriana A. Perez ◽  
William N. Voss ◽  
Joseph N. Pucella ◽  
Lee Serpas ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Type I Interferon ◽  
Plasmacytoid Dendritic Cells ◽  
Type I ◽  
Cell Responses ◽  
B Cell Responses

scholarly journals Human Cytomegalovirus Differentially Controls B Cell and T Cell Responses through Effects on Plasmacytoid Dendritic Cells

2007 ◽  
Vol 179 (11) ◽  
pp. 7767-7776 ◽  
Author(s):  
Stefania Varani ◽  
Madeleine Cederarv ◽  
Sari Feld ◽  
Charlotte Tammik ◽  
Giada Frascaroli ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
B Cell ◽  
Human Cytomegalovirus ◽  
T Cell Responses ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Responses

scholarly journals Clinical Adjuvant Combinations Stimulate Potent B-Cell Responses In Vitro by Activating Dermal Dendritic Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63785 ◽  
Author(s):  
Katie Matthews ◽  
Nancy P. Y. Chung ◽  
Per Johan Klasse ◽  
Magda Moutaftsi ◽  
Darrick Carter ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Cell Responses ◽  
B Cell Responses

scholarly journals Extrafollicular B cell activation by marginal zone dendritic cells drives T cell–dependent antibody responses

2012 ◽  
Vol 209 (10) ◽  
pp. 1825-1840 ◽  
Author(s):  
Craig P. Chappell ◽  
Kevin E. Draves ◽  
Natalia V. Giltiay ◽  
Edward A. Clark
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
B Cells ◽  
B Cell ◽  
Cell Activation ◽  
Marginal Zone ◽  
Receptor Expression ◽  
B Cell Activation ◽  
Cell Responses ◽  
B Cell Responses

Dendritic cells (DCs) are best known for their ability to activate naive T cells, and emerging evidence suggests that distinct DC subsets induce specialized T cell responses. However, little is known concerning the role of DC subsets in the initiation of B cell responses. We report that antigen (Ag) delivery to DC-inhibitory receptor 2 (DCIR2) found on marginal zone (MZ)–associated CD8α− DCs in mice leads to robust class-switched antibody (Ab) responses to a T cell–dependent (TD) Ag. DCIR2+ DCs induced rapid up-regulation of multiple B cell activation markers and changes in chemokine receptor expression, resulting in accumulation of Ag-specific B cells within extrafollicular splenic bridging channels as early as 24 h after immunization. Ag-specific B cells primed by DCIR2+ DCs were remarkably efficient at driving naive CD4 T cell proliferation, yet DCIR2-induced responses failed to form germinal centers or undergo affinity maturation of serum Ab unless toll-like receptor (TLR) 7 or TLR9 agonists were included at the time of immunization. These results demonstrate DCIR2+ DCs have a unique capacity to initiate extrafollicular B cell responses to TD Ag, and thus define a novel division of labor among splenic DC subsets for B cell activation during humoral immune responses.

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