scholarly journals IL-33 Induces a Hyporesponsive Phenotype in Human and Mouse Mast Cells

2012 ◽  
Vol 190 (2) ◽  
pp. 531-538 ◽  
Author(s):  
Mi-Yeon Jung ◽  
Daniel Smrž ◽  
Avanti Desai ◽  
Geethani Bandara ◽  
Tomonobu Ito ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human And Mouse

scholarly journals 352 Neuromedin U directly activates human and mouse skin mast cells

2017 ◽  
Vol 137 (10) ◽  
pp. S253
Author(s):  
Y. Matsuo ◽  
Y. Yanase ◽  
S. Tanaka ◽  
K. Furuta ◽  
M. Hide
Keyword(s):  
Mast Cells ◽  
Mouse Skin ◽  
Human And Mouse

scholarly journals Differential effects of C5a on human and mouse mast cells may be mediated by C5aR and C5L2

2010 ◽  
Vol 6 (S1) ◽  
Author(s):  
P Pundir ◽  
CH Sheen ◽  
A Catalli ◽  
V Karpov ◽  
K Cianflone ◽  
...  
Keyword(s):  
Mast Cells ◽  
Differential Effects ◽  
Human And Mouse

Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE

Science ◽  
2020 ◽  
Vol 370 (6519) ◽  
pp. 941-950 ◽  
Author(s):  
Rasha Msallam ◽  
Jozef Balla ◽  
Abhay P. S. Rathore ◽  
Hassen Kared ◽  
Benoit Malleret ◽  
...  
Keyword(s):  
Mast Cells ◽  
Airway Inflammation ◽  
Allergic Disease ◽  
Immunoglobulin E ◽  
Early Age ◽  
Allergic Reactions ◽  
Neonatal Fc Receptor ◽  
Effector Cells ◽  
Human And Mouse ◽  
Central Effector

Mast cells (MCs) are central effector cells in allergic reactions that are often mediated by immunoglobulin E (IgE). Allergies commonly start at an early age, and both MCs and IgE are detectable in fetuses. However, the origin of fetal IgE and whether fetal MCs can degranulate in response to IgE-dependent activation are presently unknown. Here, we show that human and mouse fetal MCs phenotypically mature through pregnancy and can be sensitized by maternal IgE. IgE crossed the placenta, dependent on the fetal neonatal Fc receptor (FcRN), and sensitized fetal MCs for allergen-specific degranulation. Both passive and active prenatal sensitization conferred allergen sensitivity, resulting in postnatal skin and airway inflammation after the first allergen encounter. We report a role for MCs within the developing fetus and demonstrate that fetal MCs may contribute to antigen-specific vertical transmission of allergic disease.

scholarly journals Mast cell–expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis

2008 ◽  
Vol 205 (10) ◽  
pp. 2207-2220 ◽  
Author(s):  
Brian A. Zabel ◽  
Susumu Nakae ◽  
Luis Zúñiga ◽  
Ji-Yun Kim ◽  
Takao Ohyama ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Immune Responses ◽  
Cell Signaling ◽  
Orphan Receptor ◽  
Passive Cutaneous Anaphylaxis ◽  
Ige Mediated ◽  
Human And Mouse

Mast cells contribute importantly to both protective and pathological IgE-dependent immune responses. We show that the mast cell–expressed orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell–dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte infiltrates associated with such reactions in mice. We further identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. In contrast to other “silent” or professional chemokine interreceptors, chemerin binding does not trigger ligand internalization. Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1.

scholarly journals Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract

2009 ◽  
Vol 296 (6) ◽  
pp. G1370-G1381 ◽  
Author(s):  
Pedro J. Gomez-Pinilla ◽  
Simon J. Gibbons ◽  
Michael R. Bardsley ◽  
Andrea Lorincz ◽  
Maria J. Pozo ◽  
...  
Keyword(s):  
Mast Cells ◽  
Interstitial Cells Of Cajal ◽  
Neuromuscular Disorders ◽  
Muscularis Propria ◽  
Interstitial Cells ◽  
Specific Marker ◽  
Human Tissues ◽  
Immunofluorescence Labeling ◽  
Cells Of Cajal ◽  
Human And Mouse

Populations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal neuromuscular disorders. ICC are identified typically by ultrastructure and expression of Kit (CD117), a protein that is also expressed on mast cells. No other molecular marker currently exists to independently identify ICC. The expression of ANO1 (DOG1, TMEM16A), a Ca2+-activated Cl− channel, in gastrointestinal stromal tumors suggests it may be useful as an ICC marker. The aims of this study were therefore to determine the distribution of Ano1 immunoreactivity compared with Kit and to establish whether Ano1 is a reliable marker for human and mouse ICC. Expression of Ano1 in human and mouse stomach, small intestine, and colon was investigated by immunofluorescence labeling using antibodies to Ano1 alone and in combination with antibodies to Kit. Colocalization of immunoreactivity was demonstrated by epifluorescence and confocal microscopy. In the muscularis propria, Ano1 immunoreactivity was restricted to cells with the morphology and distribution of ICC. All Ano1-positive cells in the muscularis propria were also Kit positive. Kit-expressing mast cells were not Ano1 positive. Some non-ICC in the mucosa and submucosa of human tissues were Ano1 positive but Kit negative. A few (3.2%) Ano1-positive cells in the human gastric muscularis propria were labeled weakly for Kit. Ano1 labels all classes of ICC and represents a highly specific marker for studying the distribution of ICC in mouse and human tissues with an advantage over Kit since it does not label mast cells.

scholarly journals Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor

Blood ◽  
2005 ◽  
Vol 107 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Jian C. Qi ◽  
Jing Wang ◽  
Sravan Mandadi ◽  
Kumiko Tanaka ◽  
Basil D. Roufogalis ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human And Mouse

scholarly journals Pro-atherogenic lung and oral pathogens induce an inflammatory response in human and mouse mast cells

2008 ◽  
Vol 13 (1) ◽  
pp. 103-113 ◽  
Author(s):  
Anna Oksaharju ◽  
Jani Lappalainen ◽  
Anita M. Tuomainen ◽  
Pirkko J. Pussinen ◽  
Mirja Puolakkainen ◽  
...  
Keyword(s):  
Mast Cells ◽  
Inflammatory Response ◽  
Oral Pathogens ◽  
Human And Mouse

scholarly journals Human and Mouse Mast Cells Express and Secrete the GPI-Anchored Isoform of CD160

2011 ◽  
Vol 131 (4) ◽  
pp. 916-924 ◽  
Author(s):  
Nicolas Ortonne ◽  
Caroline Ram-Wolff ◽  
Jérôme Giustiniani ◽  
Anne Marie-Cardine ◽  
Martine Bagot ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human And Mouse
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