scholarly journals Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

2011 ◽  
Vol 187 (11) ◽  
pp. 5510-5514 ◽  
Author(s):  
John R. Teijaro ◽  
Damian Turner ◽  
Quynh Pham ◽  
E. John Wherry ◽  
Leo Lefrançois ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Cd4 T Cells ◽  
Respiratory Virus ◽  
Cutting Edge ◽  
Respiratory Virus Infection ◽  
Memory Cd4 T Cells ◽  
Optimal Protection

scholarly journals Protection from Respiratory Virus Infections Can Be Mediated by Antigen-Specific Cd4+ T Cells That Persist in the Lungs

2001 ◽  
Vol 193 (8) ◽  
pp. 981-986 ◽  
Author(s):  
Robert J. Hogan ◽  
Weimin Zhong ◽  
Edward J. Usherwood ◽  
Tres Cookenham ◽  
Alan D. Roberts ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Cellular Immunity ◽  
Cd4 T Cells ◽  
Respiratory Virus ◽  
Critical Role ◽  
Lymphoid Tissues ◽  
Virus Infections ◽  
Respiratory Virus Infections ◽  
Memory Cd4 T Cells

Although CD4+ T cells have been shown to mediate protective cellular immunity against respiratory virus infections, the underlying mechanisms are poorly understood. For example, although phenotypically distinct populations of memory CD4+ T cells have been identified in different secondary lymphoid tissues, it is not known which subpopulations mediate protective cellular immunity. In this report, we demonstrate that virus-specific CD4+ T cells persist in the lung tissues and airways for several months after Sendai virus infection of C57BL/6 mice. A large proportion of these cells possess a highly activated phenotype (CD44hi, CD62Llo, CD43hi, and CD25hi) and express immediate effector function as indicated by the production of interferon γ after a 5-h restimulation in vitro. Furthermore, intratracheal adoptive transfer of lung memory cells into β2m-deficient mice demonstrated that lung-resident virus-specific CD4+ T cells mediated a substantial degree of protection against secondary virus infection. Taken together, these data demonstrate that activated memory CD4+ T cells persisting at mucosal sites play a critical role in mediating protective cellular immunity.

Mice Lacking CD8+ T Cells Develop Greater Numbers of IgA-Producing Cells in Response to a Respiratory Virus Infection

Virology ◽  
1994 ◽  
Vol 204 (1) ◽  
pp. 234-241 ◽  
Author(s):  
L. Hyland ◽  
S. Hou ◽  
C. Coleclough ◽  
T. Takimoto ◽  
P.C. Doherty
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Cd8 T Cells ◽  
Respiratory Virus ◽  
Respiratory Virus Infection

scholarly journals Clonally Related CD8+T Cells Responsible for Rapid Population of Both Diffuse Nasal-Associated Lymphoid Tissue and Lung After Respiratory Virus Infection

2011 ◽  
Vol 187 (2) ◽  
pp. 835-841 ◽  
Author(s):  
Sherri L. Surman ◽  
Rajeev Rudraraju ◽  
David L. Woodland ◽  
Pradyot Dash ◽  
Paul G. Thomas ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Cd8 T Cells ◽  
Lymphoid Tissue ◽  
Respiratory Virus ◽  
Respiratory Virus Infection

scholarly journals Cutting Edge: L-Selectin (CD62L) Expression Distinguishes Small Resting Memory CD4+T Cells That Preferentially Respond to Recall Antigen

2003 ◽  
Vol 170 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Richard L. Hengel ◽  
Vishakha Thaker ◽  
Mark V. Pavlick ◽  
Julia A. Metcalf ◽  
Glynn Dennis ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Cutting Edge ◽  
Recall Antigen ◽  
Memory Cd4 T Cells

scholarly journals Proliferative Expansion and Acquisition of Effector Activity by Memory CD4+T Cells in the Lungs following Pulmonary Virus Infection

2008 ◽  
Vol 180 (5) ◽  
pp. 2957-2966 ◽  
Author(s):  
Erika L. Wissinger ◽  
Whitney W. Stevens ◽  
Steven M. Varga ◽  
Thomas J. Braciale
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Cd4 T Cells ◽  
Effector Activity ◽  
Memory Cd4 T Cells

scholarly journals Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells

2018 ◽  
Vol 200 (8) ◽  
pp. 2690-2702 ◽  
Author(s):  
Roberto Tinoco ◽  
Florent Carrette ◽  
Monique L. Henriquez ◽  
Yu Fujita ◽  
Linda M. Bradley
Keyword(s):  
T Cells ◽  
Influenza Virus ◽  
Virus Infection ◽  
Cd4 T Cells ◽  
Influenza Virus Infection ◽  
Memory Cd4 T Cells
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